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Start Over Author "Yang, Tao" Journal nature communications
37 results on '"Yang, Tao"'

1. Photosynthesis of Au8Cu6 nanocluster for photocatalysis in oxidative functionalization of alkynes

Author

Yan Zhao, Ze-Min Zhu, Weigang Fan, Wanli Zhu, Jing-Jing Yang, Yang Tao, Wenwen Fei, Hong Bi, Sheng Zhang, and Man-Bo Li

Subjects
Science
Abstract

Abstract Ligand-protected metal nanoclusters provide an ideal platform for investigating photoredox catalysis. The central challenge is balancing their stability and catalytic activity. Here we show a photochemical reduction–oxidation cascade method for synthesizing an Au8Cu6 nanocluster, which features a robust structure and active surface. Photoredox catalytic activity of Au8Cu6 is developed for the functionalization of alkynes under oxidative conditions. Mechanism studies based on the precise structure reveal the catalytic process of the Au8Cu6 nanocluster. Oxidant-dependent selectivity of Au8Cu6 catalysis is developed for chemodivergent synthesis of mono- and di-functionalized products in high efficiency. The results will stimulate more research on metal nanocluster synthesis and catalysis.

Published
2024
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8. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines

Author

Zhu, Qionghua, Zhao, Xin, Zhang, Yuanhang, Li, Yanping, Liu, Shang, Han, Jingxuan, Sun, Zhiyuan, Wang, Chunqing, Deng, Daqi, Wang, Shanshan, Tang, Yisen, Huang, Yaling, Jiang, Siyuan, Tian, Chi, Chen, Xi, Yuan, Yue, Li, Zeyu, Yang, Tao, Lai, Tingting, Liu, Yiqun, Yang, Wenzhen, Zou, Xuanxuan, Zhang, Mingyuan, Cui, Huanhuan, Liu, Chuanyu, Jin, Xin, Hu, Yuhui, Chen, Ao, Xu, Xun, Li, Guipeng, Hou, Yong, Liu, Longqi, Liu, Shiping, Fang, Liang, Chen, Wei, and Wu, Liang

Published
2023
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18. Characterization of the COPD alveolar niche using single-cell RNA sequencing

Author

Sauler, Maor, McDonough, John E., Adams, Taylor S., Kothapalli, Neeharika, Barnthaler, Thomas, Werder, Rhiannon B., Schupp, Jonas C., Nouws, Jessica, Robertson, Matthew J., Coarfa, Cristian, Yang, Tao, Chioccioli, Maurizio, Omote, Norihito, Cosme, Jr, Carlos, Poli, Sergio, Ayaub, Ehab A., Chu, Sarah G., Jensen, Klaus H., Gomez, Jose L., Britto, Clemente J., Raredon, Micha Sam B., Niklason, Laura E., Wilson, Andrew A., Timshel, Pascal N., Kaminski, Naftali, and Rosas, Ivan O.

Published
2022
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19. Electrically controlled nonvolatile switching of single-atom magnetism in a Dy@C84 single-molecule transistor.

Author

Wang, Feng, Shen, Wangqiang, Shui, Yuan, Chen, Jun, Wang, Huaiqiang, Wang, Rui, Qin, Yuyuan, Wang, Xuefeng, Wan, Jianguo, Zhang, Minhao, Lu, Xing, Yang, Tao, and Song, Fengqi

Subjects
MAGNETISM, SCANNING tunneling microscopy, ZEEMAN effect, MAGNETIC transitions, RESONANT tunneling
Abstract

Single-atom magnetism switching is a key technique towards the ultimate data storage density of computer hard disks and has been conceptually realized by leveraging the spin bistability of a magnetic atom under a scanning tunnelling microscope. However, it has rarely been applied to solid-state transistors, an advancement that would be highly desirable for enabling various applications. Here, we demonstrate realization of the electrically controlled Zeeman effect in Dy@C84 single-molecule transistors, thus revealing a transition in the magnetic moment from 3.8 μ B to 5.1 μ B for the ground-state GN at an electric field strength of 3 − 10 MV/cm. The consequent magnetoresistance significantly increases from 600% to 1100% at the resonant tunneling point. Density functional theory calculations further corroborate our realization of nonvolatile switching of single-atom magnetism, and the switching stability emanates from an energy barrier of 92 meV for atomic relaxation. These results highlight the potential of using endohedral metallofullerenes for high-temperature, high-stability, high-speed, and compact single-atom magnetic data storage. Manipulating single-atom magnetism via an electric field promotes the downsizing of memories and transistors towards the atomic limit. Wang et al. show the electrically controlled Zeeman effect in Dy@C84 single-molecule transistors with magnetoresistance from 600% to 1,100% at the resonant tunnelling point. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

Author

Yao, Yikun, primary, Chen, Siyuan, additional, Cao, Mengtao, additional, Fan, Xing, additional, Yang, Tao, additional, Huang, Yin, additional, Song, Xinyang, additional, Li, Yongqin, additional, Ye, Lilin, additional, Shen, Nan, additional, Shi, Yufang, additional, Li, Xiaoxia, additional, Wang, Feng, additional, and Qian, Youcun, additional

Published
2017
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32. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Author

Wrobel, Eva, primary, Rothenberg, Ina, additional, Krisp, Christoph, additional, Hundt, Franziska, additional, Fraenzel, Benjamin, additional, Eckey, Karina, additional, Linders, Joannes T. M., additional, Gallacher, David J., additional, Towart, Rob, additional, Pott, Lutz, additional, Pusch, Michael, additional, Yang, Tao, additional, Roden, Dan M., additional, Kurata, Harley T., additional, Schulze-Bahr, Eric, additional, Strutz-Seebohm, Nathalie, additional, Wolters, Dirk, additional, and Seebohm, Guiscard, additional

Published
2016
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33. TSC1 controls macrophage polarization to prevent inflammatory disease

Author

Zhu, Linnan, primary, Yang, Tao, additional, Li, Longjie, additional, Sun, Lina, additional, Hou, Yuzhu, additional, Hu, Xuelian, additional, Zhang, Lianjun, additional, Tian, Hongling, additional, Zhao, Qingjie, additional, Peng, Jianxia, additional, Zhang, Hongbing, additional, Wang, Ruoyu, additional, Yang, Zhongzhou, additional, Zhang, Lianfeng, additional, and Zhao, Yong, additional

Published
2014
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34. Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging

Author

Xiong, Hanqing, primary, Zhou, Zhenqiao, additional, Zhu, Mingqiang, additional, Lv, Xiaohua, additional, Li, Anan, additional, Li, Shiwei, additional, Li, Longhui, additional, Yang, Tao, additional, Wang, Siming, additional, Yang, Zhongqin, additional, Xu, Tonghui, additional, Luo, Qingming, additional, Gong, Hui, additional, and Zeng, Shaoqun, additional

Published
2014
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35. Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.

Author

Yao, Yikun, Chen, Siyuan, Cao, Mengtao, Fan, Xing, Yang, Tao, Huang, Yin, Song, Xinyang, Li, Yongqin, Ye, Lilin, Shen, Nan, Shi, Yufang, Li, Xiaoxia, Wang, Feng, and Qian, Youcun

Abstract

The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8+ T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1β maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity. [ABSTRACT FROM AUTHOR]

Published
2017
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36. ParSE-seq: a calibrated multiplexed assay to facilitate the clinical classification of putative splice-altering variants.

Author

O'Neill MJ, Yang T, Laudeman J, Calandranis ME, Harvey ML, Solus JF, Roden DM, and Glazer AM

Subjects
Humans, Arrhythmias, Cardiac genetics, RNA Splice Sites genetics, CRISPR-Cas Systems genetics, Calibration, High-Throughput Nucleotide Sequencing methods, Genetic Variation, Introns genetics, HEK293 Cells, Induced Pluripotent Stem Cells metabolism, Myocytes, Cardiac metabolism, Myocytes, Cardiac cytology, RNA Splicing genetics, NAV1.5 Voltage-Gated Sodium Channel genetics, NAV1.5 Voltage-Gated Sodium Channel metabolism
Abstract

Interpreting the clinical significance of putative splice-altering variants outside canonical splice sites remains difficult without time-intensive experimental studies. To address this, we introduce Parallel Splice Effect Sequencing (ParSE-seq), a multiplexed assay to quantify variant effects on RNA splicing. We first apply this technique to study hundreds of variants in the arrhythmia-associated gene SCN5A. Variants are studied in 'minigene' plasmids with molecular barcodes to allow pooled variant effect quantification. We perform experiments in two cell types, including disease-relevant induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). The assay strongly separates known control variants from ClinVar, enabling quantitative calibration of the ParSE-seq assay. Using these evidence strengths and experimental data, we reclassify 29 of 34 variants with conflicting interpretations and 11 of 42 variants of uncertain significance. In addition to intronic variants, we show that many synonymous and missense variants disrupted RNA splicing. Two splice-altering variants in the assay also disrupt splicing and sodium current when introduced into iPSC-CMs by CRISPR-Cas9 editing. ParSE-seq provides high-throughput experimental data for RNA-splicing to support precision medicine efforts and can be readily adopted to study other loss-of-function genotype-phenotype relationships., (© 2024. The Author(s).)

Published
2024
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37. Antigen-specific CD8 + T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.

Author

Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, and Qian Y

Subjects
Adaptive Immunity, Animals, Bone Marrow Cells, Bone Marrow Transplantation, Cell Line, Tumor, Cytotoxicity, Immunologic, Dendritic Cells immunology, Dendritic Cells metabolism, Disease Models, Animal, Humans, Inflammasomes metabolism, Interleukin-1beta immunology, Interleukin-1beta metabolism, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, NLR Family, Pyrin Domain-Containing 3 Protein genetics, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Perforin genetics, Perforin immunology, Xenograft Model Antitumor Assays, Graft vs Host Disease immunology, Inflammasomes immunology, NLR Family, Pyrin Domain-Containing 3 Protein immunology, Neoplasms immunology, Perforin metabolism, T-Lymphocytes, Cytotoxic immunology
Abstract

The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8 + T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1β maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.

Published
2017
Full Text
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