Search

Your search keyword '"YANG Jing"' showing total 270 results
Start Over Author "YANG Jing" Journal nature communications
270 results on '"YANG Jing"'

10. Structural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing

Author

Shi, Jinlong, Jia, Zhilong, Sun, Jinxiu, Wang, Xiaoreng, Zhao, Xiaojing, Zhao, Chenghui, Liang, Fan, Song, Xinyu, Guan, Jiawei, Jia, Xue, Yang, Jing, Chen, Qi, Yu, Kang, Jia, Qian, Wu, Jing, Wang, Depeng, Xiao, Yuhui, Xu, Xiaoman, Liu, Yinzhe, Wu, Shijing, Zhong, Qin, Wu, Jue, Cui, Saijia, Bo, Xiaochen, Wu, Zhenzhou, Park, Minsung, Kellis, Manolis, and He, Kunlun

Published
2023
Full Text
View/download PDF

21. FAM13A affects body fat distribution and adipocyte function.

Author

Fathzadeh, Mohsen, Li, Jiehan, Rao, Abhiram, Cook, Naomi, Chennamsetty, Indumathi, Seldin, Marcus, Zhou, Xiang, Sangwung, Panjamaporn, Gloudemans, Michael J, Keller, Mark, Attie, Allan, Yang, Jing, Wabitsch, Martin, Carcamo-Orive, Ivan, Tada, Yuko, Lusis, Aldons J, Shin, Myung Kyun, Molony, Cliona M, McLaughlin, Tracey, Reaven, Gerald, Montgomery, Stephen B, Reilly, Dermot, Quertermous, Thomas, Ingelsson, Erik, and Knowles, Joshua W

Abstract

Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.

Published
2020

35. Contact-electro-catalytic CO2 reduction from ambient air.

Author

Wang, Nannan, Jiang, Wenbin, Yang, Jing, Feng, Haisong, Zheng, Youbin, Wang, Sheng, Li, Bofan, Heng, Jerry Zhi Xiong, Ong, Wai Chung, TAN, Hui Ru, Zhang, Yong-Wei, Wang, Daoai, Ye, Enyi, and Li, Zibiao

Subjects
POLYVINYLIDENE fluoride, COPPER, CHARGE exchange, ENERGY consumption, ELECTROLYTIC reduction, CATALYSTS
Abstract

Traditional catalytic techniques often encounter obstacles in the search for sustainable solutions for converting CO2 into value-added products because of their high energy consumption and expensive catalysts. Here, we introduce a contact-electro-catalysis approach for CO2 reduction reaction, achieving a CO Faradaic efficiency of 96.24%. The contact-electro-catalysis is driven by a triboelectric nanogenerator consisting of electrospun polyvinylidene fluoride loaded with single Cu atoms-anchored polymeric carbon nitride (Cu-PCN) catalysts and quaternized cellulose nanofibers (CNF). Mechanistic investigation reveals that the single Cu atoms on Cu-PCN can effectively enrich electrons during contact electrification, facilitating electron transfer upon their contact with CO2 adsorbed on quaternized CNF. Furthermore, the strong adsorption of CO2 on quaternized CNF allows efficient CO2 capture at low concentrations, thus enabling the CO2 reduction reaction in the ambient air. Compared to the state-of-the-art air-based CO2 reduction technologies, contact-electro-catalysis achieves a superior CO yield of 33 μmol g−1 h−1. This technique provides a solution for reducing airborne CO2 emissions while advancing chemical sustainability strategy. Traditional catalytic techniques often encounter obstacles in the search for sustainable solutions for converting CO2 into value-added products because of their high energy consumption and expensive catalysts. Here, we introduce a contact-electro-catalysis approach for CO2 reduction reaction, achieving CO Faradaic efficiency of 96.24%. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Author

Ullman, Julie C, Yang, Jing, Sullivan, Michael, Bendor, Jacob, Levy, Jonathan, Pham, Ellen, Silm, Katlin, Seifikar, Helia, Sohal, Vikaas S, Nicoll, Roger A, and Edwards, Robert H

Subjects
Hippocampus, Neurons, Presynaptic Terminals, Synaptic Vesicles, Endosomes, Animals, Mice, Knockout, Humans, Mice, Disease Models, Animal, Calcium, Glutamic Acid, Electroencephalography, Behavior, Animal, Attention Deficit Disorder with Hyperactivity, Synaptic Transmission, Gene Expression, Hydrogen-Ion Concentration, Female, Male, Primary Cell Culture, Autism Spectrum Disorder, Sodium-Hydrogen Exchangers, Behavior, Animal, Disease Models, Knockout
Abstract

Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na+/H+ exchanger NHE9 in both autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). Plasma membrane NHEs regulate cytosolic pH, but the role of intracellular isoforms has remained unclear. We now find that inactivation of NHE9 in mice reproduces behavioral features of ASD including impaired social interaction, repetitive behaviors, and altered sensory processing. Physiological characterization reveals hyperacidic endosomes, a cell-autonomous defect in glutamate receptor expression and impaired neurotransmitter release due to a defect in presynaptic Ca2+ entry. Acute inhibition of synaptic vesicle acidification rescues release but without affecting the primary defect due to loss of NHE9.

Published
2018

44. Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Author

Wang, Yong-Fei, Zhang, Yan, Lin, Zhiming, Zhang, Huoru, Wang, Ting-You, Cao, Yujie, Morris, David L., Sheng, Yujun, Yin, Xianyong, Zhong, Shi-Long, Gu, Xiaoqiong, Lei, Yao, He, Jing, Wu, Qi, Shen, Jiangshan Jane, Yang, Jing, Lam, Tai-Hing, Lin, Jia-Huang, Mai, Zhi-Ming, Guo, Mengbiao, Tang, Yuanjia, Chen, Yanhui, Song, Qin, Ban, Bo, Mok, Chi Chiu, Cui, Yong, Lu, Liangjing, Shen, Nan, Sham, Pak C., Lau, Chak Sing, Smith, David K., Vyse, Timothy J., Zhang, Xuejun, Lau, Yu Lung, and Yang, Wanling

Published
2021
Full Text
View/download PDF

45. Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

Author

Zhang, Dali, Huang, Junlan, Sun, Xianding, Chen, Hangang, Huang, Shuo, Yang, Jing, Du, Xiaolan, Tan, Qiaoyan, Luo, Fengtao, Zhang, Ruobin, Zhou, Siru, Jiang, Wanling, Ni, Zhenhong, Wang, Zuqiang, Jin, Min, Xu, Meng, Li, Fangfang, Chen, Liang, Liu, Mi, Su, Nan, Luo, Xiaoqing, Yin, Liangjun, Zhu, Ying, Feng, Jerry Q., Chen, Di, Qi, Huabing, Chen, Lin, and Xie, Yangli

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results