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Your search keyword '"Xiaorui Han"' showing total 2 results
Start Over Author "Xiaorui Han" Journal nature communications
2 results on '"Xiaorui Han"'

1. CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy

Author

Abhinav Kaushik, Diane Dunham, Xiaorui Han, Evan Do, Sandra Andorf, Sheena Gupta, Andrea Fernandes, Laurie Elizabeth Kost, Sayantani B. Sindher, Wong Yu, Mindy Tsai, Robert Tibshirani, Scott D. Boyd, Manisha Desai, Holden T. Maecker, Stephen J. Galli, R. Sharon Chinthrajah, Rosemarie H. DeKruyff, Monali Manohar, and Kari C. Nadeau

Subjects
Science
Abstract

Oral immunotherapy (OIT) clinical trials have helped a subset of participants achieve sustained unresponsiveness (SU) to the cognate allergen. Here the authors analyse immune cells from participants from one peanut OIT trial and show that CD8+ T cell differentiation status at baseline may help to predict the likelihood of achieving SU.

Published
2022
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2. CD8

Author

Abhinav, Kaushik, Diane, Dunham, Xiaorui, Han, Evan, Do, Sandra, Andorf, Sheena, Gupta, Andrea, Fernandes, Laurie Elizabeth, Kost, Sayantani B, Sindher, Wong, Yu, Mindy, Tsai, Robert, Tibshirani, Scott D, Boyd, Manisha, Desai, Holden T, Maecker, Stephen J, Galli, R Sharon, Chinthrajah, Rosemarie H, DeKruyff, Monali, Manohar, and Kari C, Nadeau

Subjects
Arachis, Desensitization, Immunologic, Feasibility Studies, Administration, Oral, Immunologic Factors, Peanut Hypersensitivity, Cell Differentiation, Immunoglobulin E, CD8-Positive T-Lymphocytes, Allergens
Abstract

While food allergy oral immunotherapy (OIT) can provide safe and effective desensitization (DS), the immune mechanisms underlying development of sustained unresponsiveness (SU) following a period of avoidance are largely unknown. Here, we compare high dimensional phenotypes of innate and adaptive immune cell subsets of participants in a previously reported, phase 2 randomized, controlled, peanut OIT trial who achieved SU vs. DS (no vs. with allergic reactions upon food challenge after a withdrawal period; n = 21 vs. 30 respectively among total 120 intent-to-treat participants). Lower frequencies of naïve CD8

Published
2021

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