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Your search keyword '"Wolfrum, Christian"' showing total 10 results
Start Over Author "Wolfrum, Christian" Journal nature communications
10 results on '"Wolfrum, Christian"'

1. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Author

Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J. R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, and Prokesch, Andreas

Published
2024
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3. An integrated single cell and spatial transcriptomic map of human white adipose tissue

Author

Massier, Lucas, Jalkanen, Jutta, Elmastas, Merve, Zhong, Jiawei, Wang, Tongtong, Nono Nankam, Pamela A., Frendo-Cumbo, Scott, Bäckdahl, Jesper, Subramanian, Narmadha, Sekine, Takuya, Kerr, Alastair G., Tseng, Ben T. P., Laurencikiene, Jurga, Buggert, Marcus, Lourda, Magda, Kublickiene, Karolina, Bhalla, Nayanika, Andersson, Alma, Valsesia, Armand, Astrup, Arne, Blaak, Ellen E., Ståhl, Patrik L., Viguerie, Nathalie, Langin, Dominique, Wolfrum, Christian, Blüher, Matthias, Rydén, Mikael, and Mejhert, Niklas

Published
2023
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5. GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

Author

Balazova, Lucia, Balaz, Miroslav, Horvath, Carla, Horváth, Áron, Moser, Caroline, Kovanicova, Zuzana, Ghosh, Adhideb, Ghoshdastider, Umesh, Efthymiou, Vissarion, Kiehlmann, Elke, Sun, Wenfei, Dong, Hua, Ding, Lianggong, Amri, Ez-Zoubir, Nuutila, Pirjo, Virtanen, Kirsi A., Niemi, Tarja, Ukropcova, Barbara, Ukropec, Jozef, Pelczar, Pawel, Lamla, Thorsten, Hamilton, Bradford, Neubauer, Heike, and Wolfrum, Christian

Published
2021
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9. Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice.

Author

Min Li, Li Li, Baoguo Li, Hambly, Catherine, Guanlin Wang, Yingga Wu, Zengguang Jin, Anyongqi Wang, Chaoqun Niu, Wolfrum, Christian, and Speakman, John R.

Abstract

Gut microbiota deficient mice demonstrate accelerated glucose clearance. However, which tissues are responsible for the upregulated glucose uptake remains unresolved, with different studies suggesting that browning of white adipose tissue, or modulated hepatic gluconeogenesis, may be related to enhanced glucose clearance when the gut microbiota is absent. Here, we investigate glucose uptake in 22 different tissues in 3 different mouse models. We find that gut microbiota depletion via treatment with antibiotic cocktails (ABX) promotes glucose uptake in brown adipose tissue (BAT) and cecum. Nevertheless, the adaptive thermogenesis and the expression of uncoupling protein 1 (UCP1) are dispensable for the increased glucose uptake and clearance. Deletion of Ucp1 expressing cells blunts the improvement of glucose clearance in ABX-treated mice. Our results indicate that BAT and cecum, but not white adipose tissue (WAT) or liver, contribute to the glucose uptake in the gut microbiota depleted mouse model and this response is dissociated from adaptive thermogenesis. [ABSTRACT FROM AUTHOR]

Published
2021
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10. GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

Author

Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum, University of Zurich, Wolfrum, Christian, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Slovak Academy of Sciences (SAS), Comenius University in Bratislava, Universität Zürich [Zürich] = University of Zurich (UZH), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Turku, Turku University Hospital (TYKS), University of Basel (Unibas), Boehringer Ingelheim Pharma GmbH & Co. KG, and Amri, Ez-Zoubir

Subjects
Male, Science, General Physics and Astronomy, 610 Medicine & health, 10071 Functional Genomics Center Zurich, 1600 General Chemistry, Article, General Biochemistry, Genetics and Molecular Biology, Receptors, G-Protein-Coupled, Transforming Growth Factor beta, 1300 General Biochemistry, Genetics and Molecular Biology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Animals, Homeostasis, Humans, Adipocytes, Beige, Metabolic Syndrome, Mice, Knockout, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Extracellular Matrix Proteins, Multidisciplinary, Thermogenesis, Metabolic diseases, General Chemistry, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 3100 General Physics and Astronomy, Mice, Inbred C57BL, Adipocytes, Brown, Glucose, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], 570 Life sciences, biology, Energy Metabolism, Fat metabolism, Signal Transduction
Abstract

Activation of thermogenic brown and beige adipocytes is considered as a strategy to improve metabolic control. Here, we identify GPR180 as a receptor regulating brown and beige adipocyte function and whole-body glucose homeostasis, whose expression in humans is associated with improved metabolic control. We demonstrate that GPR180 is not a GPCR but a component of the TGFβ signalling pathway and regulates the activity of the TGFβ receptor complex through SMAD3 phosphorylation. In addition, using genetic and pharmacological tools, we provide evidence that GPR180 is required to manifest Collagen triple helix repeat containing 1 (CTHRC1) action to regulate brown and beige adipocyte activity and glucose homeostasis. In this work, we show that CTHRC1/GPR180 signalling integrates into the TGFβ signalling as an alternative axis to fine-tune and achieve low-grade activation of the pathway to prevent pathophysiological response while contributing to control of glucose and energy metabolism., Activation of thermogenic adipocytes is a strategy to combat metabolic diseases. Here the authors report that GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1, and contributes to the regulation of glucose and energy metabolism.

Published
2021

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