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Start Over Author "Wietelmann, A." Journal nature communications
8 results on '"Wietelmann, A."'

2. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Author

D. Julia Trembinski, Diewertje I. Bink, Kosta Theodorou, Janina Sommer, Ariane Fischer, Anke van Bergen, Chao-Chung Kuo, Ivan G. Costa, Christoph Schürmann, Matthias S. Leisegang, Ralf P. Brandes, Tijna Alekseeva, Boris Brill, Astrid Wietelmann, Christopher N. Johnson, Alexander Spring-Connell, Manuel Kaulich, Stanislas Werfel, Stefan Engelhardt, Marc N. Hirt, Kaja Yorgan, Thomas Eschenhagen, Luisa Kirchhof, Patrick Hofmann, Nicolas Jaé, Ilka Wittig, Nazha Hamdani, Corinne Bischof, Jaya Krishnan, Riekelt H. Houtkooper, Stefanie Dimmeler, and Reinier A. Boon

Subjects
Science
Abstract

Aging induces cardiovascular disease, but which RNA molecules control cardiac aging is poorly understood. Here the authors identified the aging-regulated non-coding RNA Sarrah, which controls cardiomyocyte survival and cardiac function by inducing cardioprotective genes.

Published
2020
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3. Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome

Author

Mengnan Li, Shin-ya Nishio, Chie Naruse, Meghan Riddell, Sabrina Sapski, Tatsuya Katsuno, Takao Hikita, Fatemeh Mizapourshafiyi, Fiona M. Smith, Leanne T. Cooper, Min Goo Lee, Masahide Asano, Thomas Boettger, Marcus Krueger, Astrid Wietelmann, Johannes Graumann, Bryan W. Day, Andrew W. Boyd, Stefan Offermanns, Shin-ichiro Kitajiri, Shin-ichi Usami, and Masanori Nakayama

Subjects
Science
Abstract

While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations. Here the authors identify EPHA2 as another causative gene of Pendred syndrome with SLC26A4.

Published
2020
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4. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Author

Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, and Soni S. Pullamsetti

Subjects
Science
Abstract

Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.

Published
2019
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5. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Author

Astrid Wietelmann, Soni Savai Pullamsetti, Chanil Valasarajan, Christian Muecke, Swati Dabral, Friedrich Grimminger, Thomas Muley, Werner Seeger, Christos Samakovlis, Gregg L. Semenza, Rajkumar Savai, Norbert Weissmann, Mario Schmoranzer, Michael Meister, and Tamina Seeger-Nukpezah

Subjects
0301 basic medicine, Scaffold protein, Male, Lung Neoplasms, General Physics and Astronomy, 02 engineering and technology, Mice, Glycolysis, lcsh:Science, Promoter Regions, Genetic, Lung, Protein Kinase C, Mice, Knockout, Multidisciplinary, Chemistry, 021001 nanoscience & nanotechnology, Warburg effect, Cell Hypoxia, Knockout mouse, Hypertension, NADPH Oxidase 1, Phosphorylation, medicine.symptom, Signal transduction, 0210 nano-technology, Protein Binding, Signal Transduction, musculoskeletal diseases, endocrine system, Hypertension, Pulmonary, Science, Myocytes, Smooth Muscle, Primary Cell Culture, Pulmonary Artery, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Animals, Humans, Protein kinase A, Respiratory tract diseases, Tumor Suppressor Proteins, General Chemistry, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, Proteolysis, Cancer research, lcsh:Q, HeLa Cells
Abstract

Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized by a glycolytic switch similar to the Warburg effect in cancer. Ras association domain family 1A (RASSF1A) is a scaffold protein that acts as a tumour suppressor. Here we show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. In parallel, hypoxia inducible factor-1 α (HIF-1α) activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. Vice versa, RASSF1A binds to HIF-1α, blocks its prolyl-hydroxylation and proteasomal degradation, and thus enhances the activation of the glycolytic switch. We find that this mechanism operates in experimental hypoxia-induced PH, which is blocked in RASSF1A knockout mice, in human primary PH vascular cells, and in a subset of human lung cancer cells. We conclude that RASSF1A-HIF-1α forms a feedforward loop driving hypoxia signaling in PH and cancer., Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.

Published
2019

6. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Author

Trembinski, D. Julia, primary, Bink, Diewertje I., additional, Theodorou, Kosta, additional, Sommer, Janina, additional, Fischer, Ariane, additional, van Bergen, Anke, additional, Kuo, Chao-Chung, additional, Costa, Ivan G., additional, Schürmann, Christoph, additional, Leisegang, Matthias S., additional, Brandes, Ralf P., additional, Alekseeva, Tijna, additional, Brill, Boris, additional, Wietelmann, Astrid, additional, Johnson, Christopher N., additional, Spring-Connell, Alexander, additional, Kaulich, Manuel, additional, Werfel, Stanislas, additional, Engelhardt, Stefan, additional, Hirt, Marc N., additional, Yorgan, Kaja, additional, Eschenhagen, Thomas, additional, Kirchhof, Luisa, additional, Hofmann, Patrick, additional, Jaé, Nicolas, additional, Wittig, Ilka, additional, Hamdani, Nazha, additional, Bischof, Corinne, additional, Krishnan, Jaya, additional, Houtkooper, Riekelt H., additional, Dimmeler, Stefanie, additional, and Boon, Reinier A., additional

Published
2020
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7. Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome

Author

Li, Mengnan, primary, Nishio, Shin-ya, additional, Naruse, Chie, additional, Riddell, Meghan, additional, Sapski, Sabrina, additional, Katsuno, Tatsuya, additional, Hikita, Takao, additional, Mizapourshafiyi, Fatemeh, additional, Smith, Fiona M., additional, Cooper, Leanne T., additional, Lee, Min Goo, additional, Asano, Masahide, additional, Boettger, Thomas, additional, Krueger, Marcus, additional, Wietelmann, Astrid, additional, Graumann, Johannes, additional, Day, Bryan W., additional, Boyd, Andrew W., additional, Offermanns, Stefan, additional, Kitajiri, Shin-ichiro, additional, Usami, Shin-ichi, additional, and Nakayama, Masanori, additional

Published
2020
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8. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Author

Dabral, Swati, primary, Muecke, Christian, additional, Valasarajan, Chanil, additional, Schmoranzer, Mario, additional, Wietelmann, Astrid, additional, Semenza, Gregg L., additional, Meister, Michael, additional, Muley, Thomas, additional, Seeger-Nukpezah, Tamina, additional, Samakovlis, Christos, additional, Weissmann, Norbert, additional, Grimminger, Friedrich, additional, Seeger, Werner, additional, Savai, Rajkumar, additional, and Pullamsetti, Soni S., additional

Published
2019
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