1,568 results on '"WANG, X."'
Search Results
2. High-energy photoemission final states beyond the free-electron approximation
- Author
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Strocov, V. N., Lev, L. L., Alarab, F., Constantinou, P., Wang, X., Schmitt, T., Stock, T. J. Z., Nicolaï, L., Očenášek, J., and Minár, J.
- Published
- 2023
- Full Text
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3. Rehybridization dynamics into the pericyclic minimum of an electrocyclic reaction imaged in real-time
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Liu, Y., Sanchez, D. M., Ware, M. R., Champenois, E. G., Yang, J., Nunes, J. P. F., Attar, A., Centurion, M., Cryan, J. P., Forbes, R., Hegazy, K., Hoffmann, M. C., Ji, F., Lin, M.-F., Luo, D., Saha, S. K., Shen, X., Wang, X. J., Martínez, T. J., and Wolf, T. J. A.
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- 2023
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4. Ambipolar ferromagnetism by electrostatic doping of a manganite.
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Zheng, LM, Wang, X Renshaw, Lü, WM, Li, CJ, Paudel, TR, Liu, ZQ, Huang, Z, Zeng, SW, Han, Kun, Chen, ZH, Qiu, XP, Li, MS, Yang, Shize, Yang, B, Chisholm, Matthew F, Martin, LW, Pennycook, SJ, Tsymbal, EY, Coey, JMD, and Cao, WW
- Abstract
Complex-oxide materials exhibit physical properties that involve the interplay of charge and spin degrees of freedom. However, an ambipolar oxide that is able to exhibit both electron-doped and hole-doped ferromagnetism in the same material has proved elusive. Here we report ambipolar ferromagnetism in LaMnO3, with electron-hole asymmetry of the ferromagnetic order. Starting from an undoped atomically thin LaMnO3 film, we electrostatically dope the material with electrons or holes according to the polarity of a voltage applied across an ionic liquid gate. Magnetotransport characterization reveals that an increase of either electron-doping or hole-doping induced ferromagnetic order in this antiferromagnetic compound, and leads to an insulator-to-metal transition with colossal magnetoresistance showing electron-hole asymmetry. These findings are supported by density functional theory calculations, showing that strengthening of the inter-plane ferromagnetic exchange interaction is the origin of the ambipolar ferromagnetism. The result raises the prospect of exploiting ambipolar magnetic functionality in strongly correlated electron systems.
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- 2018
5. Large intrinsic anomalous Hall effect in SrIrO3 induced by magnetic proximity effect
- Author
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Yoo, Myoung-Woo, Tornos, J., Sander, A., Lin, Ling-Fang, Mohanta, Narayan, Peralta, A., Sanchez-Manzano, D., Gallego, F., Haskel, D., Freeland, J. W., Keavney, D. J., Choi, Y., Strempfer, J., Wang, X., Cabero, M., Vasili, Hari Babu, Valvidares, Manuel, Sanchez-Santolino, G., Gonzalez-Calbet, J. M., Rivera, A., Leon, C., Rosenkranz, S., Bibes, M., Barthelemy, A., Anane, A., Dagotto, Elbio, Okamoto, S., te Velthuis, S. G. E., Santamaria, J., and Villegas, Javier E.
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- 2021
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6. A high-entropy manganite in an ordered nanocomposite for long-term application in solid oxide cells
- Author
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Baiutti, F., Chiabrera, F., Acosta, M., Diercks, D., Parfitt, D., Santiso, J., Wang, X., Cavallaro, A., Morata, A., Wang, H., Chroneos, A., MacManus-Driscoll, J., and Tarancon, A.
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- 2021
- Full Text
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7. A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo
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Hernandez, J. O. R., Wang, X., Vazquez-Segoviano, M., Lopez-Marfil, M., Sobral-Reyes, M. F., Moran-Horowich, A., Sundberg, M., Lopez-Cantu, D. O., Probst, C. K., Ruiz-Esparza, G. U., Giannikou, K., Abdi, R., Henske, E. P., Kwiatkowski, D. J., Sahin, M., and Lemos, D. R.
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- 2021
- Full Text
- View/download PDF
8. Spin–orbit torque switching in a T-type magnetic configuration with current orthogonal to easy axes
- Author
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Kong, W. J., Wan, C. H., Wang, X., Tao, B. S., Huang, L., Fang, C., Guo, C. Y., Guang, Y., Irfan, M., and Han, X. F.
- Published
- 2019
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9. Scale law of complex deformation transitions of nanotwins in stainless steel
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Chen, A. Y., Zhu, L. L., Sun, L. G., Liu, J. B., Wang, H. T., Wang, X. Y., Yang, J. H., and Lu, J.
- Published
- 2019
- Full Text
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10. Beyond a phenomenological description of magnetostriction
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Reid, A. H., Shen, X., Maldonado, P., Chase, T., Jal, E., Granitzka, P. W., Carva, K., Li, R. K., Li, J., Wu, L., Vecchione, T., Liu, T., Chen, Z., Higley, D. J., Hartmann, N., Coffee, R., Wu, J., Dakovski, G. L., Schlotter, W. F., Ohldag, H., Takahashi, Y. K., Mehta, V., Hellwig, O., Fry, A., Zhu, Y., Cao, J., Fullerton, E. E., Stöhr, J., Oppeneer, P. M., Wang, X. J., and Dürr, H. A.
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- 2018
- Full Text
- View/download PDF
11. Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
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Krohn, L., Heilbron, K., Blauwendraat, C., Reynolds, R. H., Yu, E., Senkevich, K., Rudakou, U., Estiar, M. A., Gustavsson, E. K., Brolin, K., Ruskey, J. A., Freeman, K., Asayesh, F., Chia, R., Arnulf, I., M. T. M., Hu, Montplaisir, J. Y., Gagnon, J. -F., Desautels, A., Dauvilliers, Y., Gigli, G. L., Valente, M., Janes, F., Bernardini, A., Hogl, B., Stefani, A., Ibrahim, A., Sonka, K., Kemlink, D., Oertel, W., Janzen, A., Plazzi, G., Biscarini, F., Antelmi, E., Figorilli, M., Puligheddu, M., Mollenhauer, B., Trenkwalder, C., Sixel-Doring, F., Cochen De Cock, V., Monaca, C. C., Heidbreder, A., Ferini-Strambi, L., Dijkstra, F., Viaene, M., Abril, B., Boeve, B. F., Aslibekyan, S., Auton, A., Babalola, E., Bell, R. K., Bielenberg, J., Bryc, K., Bullis, E., Coker, D., Partida, G. C., Dhamija, D., Das, S., Elson, S. L., Filshtein, T., Fletez-Brant, K., Fontanillas, P., Freyman, W., Gandhi, P. M., Hicks, B., Hinds, D. A., Jewett, E. M., Jiang, Y., Kukar, K., Lin, K. -H., Lowe, M., Mccreight, J. C., Mcintyre, M. H., Micheletti, S. J., Moreno, M. E., Mountain, J. L., Nandakumar, P., Noblin, E. S., O'Connell, J., Petrakovitz, A. A., Poznik, G. D., Schumacher, M., Shastri, A. J., Shelton, J. F., Shi, J., Shringarpure, S., Tran, V., Tung, J. Y., Wang, X., Wang, W., Weldon, C. H., Wilton, P., Hernandez, A., Wong, C., Tchakoute, C. T., Scholz, S. W., Ryten, M., Bandres-Ciga, S., Noyce, A., Cannon, P., Pihlstrom, L., Nalls, M. A., Singleton, A. B., Rouleau, G. A., Postuma, R. B., Gan-Or, Z., and 23andMe Research Team
- Subjects
Multidisciplinary ,Risk factors ,General Physics and Astronomy ,Genomics ,General Chemistry ,Human medicine ,Genome-wide association studies ,General Biochemistry, Genetics and Molecular Biology - Abstract
Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more severe subtype. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB2. Expression analyses highlight SNCA-AS1 and potentially SCARB2 differential expression in different brain regions in RBD, with SNCA-AS1 further supported by colocalization analyses. Polygenic risk score, pathway analysis, and genetic correlations provide further insights into RBD genetics, highlighting RBD as a unique alpha-synucleinopathy subpopulation that will allow future early intervention. REM-sleep behavior disorder often precedes Parkinson's disease or dementia. Here, the authors perform a genome-wide association study for REM-sleep behavior disorder, and discover how it potentially affects gene expression in the brain.
- Published
- 2022
12. Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- Author
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Menden M, Wang D, Mason M, Szalai B, Bulusu K, Guan Y, Yu T, Kang J, Jeon M, Wolfinger R, Nguyen T, Zaslavskiy M, Jang I, Ghazoui Z, Ahsen M, Vogel R, Neto E, Norman T, Tang E, Garnett M, Di Veroli G, Fawell S, Stolovitzky G, Guinney J, Dry J, Saez-Rodriguez J, Abante J, Abecassis B, Aben N, Aghamirzaie D, Aittokallio T, Akhtari F, Al-lazikani B, Alam T, Allam A, Allen C, de Almeida M, Altarawy D, Alves V, Amadoz A, Anchang B, Antolin A, Ash J, Aznar V, Ba-alawi W, Bagheri M, Bajic V, Ball G, Ballester P, Baptista D, Bare C, Bateson M, Bender A, Bertrand D, Wijayawardena B, Boroevich K, Bosdriesz E, Bougouffa S, Bounova G, Brouwer T, Bryant B, Calaza M, Calderone A, Calza S, Capuzzi S, Carbonell-Caballero J, Carlin D, Carter H, Castagnoli L, Celebi R, Cesareni G, Chang H, Chen G, Chen H, Cheng L, Chernomoretz A, Chicco D, Cho K, Cho S, Choi D, Choi J, Choi K, Choi M, De Cock M, Coker E, Cortes-Ciriano I, Cserzo M, Cubuk C, Curtis C, Van Daele D, Dang C, Dijkstra T, Dopazo J, Draghici S, Drosou A, Dumontier M, Ehrhart F, Eid F, ElHefnawi M, Elmarakeby H, van Engelen B, Engin H, de Esch I, Evelo C, Falcao A, Farag S, Fernandez-Lozano C, Fisch K, Flobak A, Fornari C, Foroushani A, Fotso D, Fourches D, Friend S, Frigessi A, Gao F, Gao X, Gerold J, Gestraud P, Ghosh S, Gillberg J, Godoy-Lorite A, Godynyuk L, Godzik A, Goldenberg A, Gomez-Cabrero D, Gonen M, de Graaf C, Gray H, Grechkin M, Guimera R, Guney E, Haibe-Kains B, Han Y, Hase T, He D, He L, Heath L, Hellton K, Helmer-Citterich M, Hidalgo M, Hidru D, Hill S, Hochreiter S, Hong S, Hovig E, Hsueh Y, Hu Z, Huang J, Huang R, Hunyady L, Hwang J, Hwang T, Hwang W, Hwang Y, Isayev O, Walk O, Jack J, Jahandideh S, Ji J, Jo Y, Kamola P, Kanev G, Karacosta L, Karimi M, Kaski S, Kazanov M, Khamis A, Khan S, Kiani N, Kim A, Kim J, Kim K, Kim S, Kim Y, Kirk P, Kitano H, Klambauer G, Knowles D, Ko M, Kohn-Luque A, Kooistra A, Kuenemann M, Kuiper M, Kurz C, Kwon M, van Laarhoven T, Laegreid A, Lederer S, Lee H, Lee J, Lee Y, Leppaho E, Lewis R, Li J, Li L, Liley J, Lim W, Lin C, Liu Y, Lopez Y, Low J, Lysenko A, Machado D, Madhukar N, De Maeyer D, Malpartida A, Mamitsuka H, Marabita F, Marchal K, Marttinen P, Mason D, Mazaheri A, Mehmood A, Mehreen A, Michaut M, Miller R, Mitsopoulos C, Modos D, Van Moerbeke M, Moo K, Motsinger-Reif A, Movva R, Muraru S, Muratov E, Mushthofa M, Nagarajan N, Nakken S, Nath A, Neuvial P, Newton R, Ning Z, De Niz C, Oliva B, Olsen C, Palmeri A, Panesar B, Papadopoulos S, Park J, Park S, Pawitan Y, Peluso D, Pendyala S, Peng J, Perfetto L, Pirro S, Plevritis S, Politi R, Poon H, Porta E, Prellner I, Preuer K, Pujana M, Ramnarine R, Reid J, Reyal F, Richardson S, Ricketts C, Rieswijk L, Rocha M, Rodriguez-Gonzalvez C, Roell K, Rotroff D, de Ruiter J, Rukawa P, Sadacca B, Safikhani Z, Safitri F, Sales-Pardo M, Sauer S, Schlichting M, Seoane J, Serra J, Shang M, Sharma A, Sharma H, Shen Y, Shiga M, Shin M, Shkedy Z, Shopsowitz K, Sinai S, Skola D, Smirnov P, Soerensen I, Soerensen P, Song J, Song S, Soufan O, Spitzmueller A, Steipe B, Suphavilai C, Tamayo S, Tamborero D, Tang J, Tanoli Z, Tarres-Deulofeu M, Tegner J, Thommesen L, Tonekaboni S, Tran H, De Troyer E, Truong A, Tsunoda T, Turu G, Tzeng G, Verbeke L, Videla S, Vis D, Voronkov A, Votis K, Wang A, Wang H, Wang P, Wang S, Wang W, Wang X, Wennerberg K, Wernisch L, Wessels L, van Westen G, Westerman B, White S, Willighagen E, Wurdinger T, Xie L, Xie S, Xu H, Yadav B, Yau C, Yeerna H, Yin J, Yu M, Yun S, Zakharov A, Zamichos A, Zanin M, Zeng L, Zenil H, Zhang F, Zhang P, Zhang W, Zhao H, Zhao L, Zheng W, Zoufir A, Zucknick M, AstraZeneca-Sanger Drug Combinatio, Ege Üniversitesi, Gönen, Mehmet (ORCID 0000-0002-2483-075X & YÖK ID 237468), Menden, Michael P., Wang, Dennis, Mason, Mike J., Szalai, Bence, Bulusu, Krishna C., Guan, Yuanfang, Yu, Thomas, Kang, Jaewoo, Jeon, Minji, Wolfinger, Russ, Nguyen, Tin, Zaslavskiy, Mikhail, Jang, In Sock, Ghazoui, Zara, Ahsen, Mehmet Eren, Vogel, Robert, Neto, Elias Chaibub, Norman, Thea, Tang, Eric K. Y., Garnett, Mathew J., Di Veroli, Giovanni Y., Fawell, Stephen, Stolovitzky, Gustavo, Guinney, Justin, Dry, Jonathan R., Saez-Rodriguez, Julio, Abante, Jordi, Abecassis, Barbara Schmitz, Aben, Nanne, Aghamirzaie, Delasa, Aittokallio, Tero, Akhtari, Farida S., Al-lazikani, Bissan, Alam, Tanvir, Allam, Amin, Allen, Chad, de Almeida, Mariana Pelicano, Altarawy, Doaa, Alves, Vinicius, Amadoz, Alicia, Anchang, Benedict, Antolin, Albert A., Ash, Jeremy R., Romeo Aznar, Victoria, Ba-alawi, Wail, Bagheri, Moeen, Bajic, Vladimir, Ball, Gordon, Ballester, Pedro J., Baptista, Delora, Bare, Christopher, Bateson, Mathilde, Bender, Andreas, Bertrand, Denis, Wijayawardena, Bhagya, Boroevich, Keith A., Bosdriesz, Evert, Bougouffa, Salim, Bounova, Gergana, Brouwer, Thomas, Bryant, Barbara, Calaza, Manuel, Calderone, Alberto, Calza, Stefano, Capuzzi, Stephen, Carbonell-Caballero, Jose, Carlin, Daniel, Carter, Hannah, Castagnoli, Luisa, Celebi, Remzi, Cesareni, Gianni, Chang, Hyeokyoon, Chen, Guocai, Chen, Haoran, Chen, Huiyuan, Cheng, Lijun, Chernomoretz, Ariel, Chicco, Davide, Cho, Kwang-Hyun, Cho, Sunghwan, Choi, Daeseon, Choi, Jaejoon, Choi, Kwanghun, Choi, Minsoo, De Cock, Martine, Coker, Elizabeth, Cortes-Ciriano, Isidro, Cserzo, Miklos, Cubuk, Cankut, Curtis, Christina, Van Daele, Dries, Dang, Cuong C., Dijkstra, Tjeerd, Dopazo, Joaquin, Draghici, Sorin, Drosou, Anastasios, Dumontier, Michel, Ehrhart, Friederike, Eid, Fatma-Elzahraa, ElHefnawi, Mahmoud, Elmarakeby, Haitham, van Engelen, Bo, Engin, Hatice Billur, de Esch, Iwan, Evelo, Chris, Falcao, Andre O., Farag, Sherif, Fernandez-Lozano, Carlos, Fisch, Kathleen, Flobak, Asmund, Fornari, Chiara, Foroushani, Amir B. K., Fotso, Donatien Chedom, Fourches, Denis, Friend, Stephen, Frigessi, Arnoldo, Gao, Feng, Gao, Xiaoting, Gerold, Jeffrey M., Gestraud, Pierre, Ghosh, Samik, Gillberg, Jussi, Godoy-Lorite, Antonia, Godynyuk, Lizzy, Godzik, Adam, Goldenberg, Anna, Gomez-Cabrero, David, de Graaf, Chris, Gray, Harry, Grechkin, Maxim, Guimera, Roger, Guney, Emre, Haibe-Kains, Benjamin, Han, Younghyun, Hase, Takeshi, He, Di, He, Liye, Heath, Lenwood S., Hellton, Kristoffer H., Helmer-Citterich, Manuela, Hidalgo, Marta R., Hidru, Daniel, Hill, Steven M., Hochreiter, Sepp, Hong, Seungpyo, Hovig, Eivind, Hsueh, Ya-Chih, Hu, Zhiyuan, Huang, Justin K., Huang, R. Stephanie, Hunyady, Laszlo, Hwang, Jinseub, Hwang, Tae Hyun, Hwang, Woochang, Hwang, Yongdeuk, Isayev, Olexandr, Walk, Oliver Bear Don't, Jack, John, Jahandideh, Samad, Ji, Jiadong, Jo, Yousang, Kamola, Piotr J., Kanev, Georgi K., Karacosta, Loukia, Karimi, Mostafa, Kaski, Samuel, Kazanov, Marat, Khamis, Abdullah M., Khan, Suleiman Ali, Kiani, Narsis A., Kim, Allen, Kim, Jinhan, Kim, Juntae, Kim, Kiseong, Kim, Kyung, Kim, Sunkyu, Kim, Yongsoo, Kim, Yunseong, Kirk, Paul D. W., Kitano, Hiroaki, Klambauer, Gunter, Knowles, David, Ko, Melissa, Kohn-Luque, Alvaro, Kooistra, Albert J., Kuenemann, Melaine A., Kuiper, Martin, Kurz, Christoph, Kwon, Mijin, van Laarhoven, Twan, Laegreid, Astrid, Lederer, Simone, Lee, Heewon, Lee, Jeon, Lee, Yun Woo, Leppaho, Eemeli, Lewis, Richard, Li, Jing, Li, Lang, Liley, James, Lim, Weng Khong, Lin, Chieh, Liu, Yiyi, Lopez, Yosvany, Low, Joshua, Lysenko, Artem, Machado, Daniel, Madhukar, Neel, De Maeyer, Dries, Malpartida, Ana Belen, Mamitsuka, Hiroshi, Marabita, Francesco, Marchal, Kathleen, Marttinen, Pekka, Mason, Daniel, Mazaheri, Alireza, Mehmood, Arfa, Mehreen, Ali, Michaut, Magali, Miller, Ryan A., Mitsopoulos, Costas, Modos, Dezso, Van Moerbeke, Marijke, Moo, Keagan, Motsinger-Reif, Alison, Movva, Rajiv, Muraru, Sebastian, Muratov, Eugene, Mushthofa, Mushthofa, Nagarajan, Niranjan, Nakken, Sigve, Nath, Aritro, Neuvial, Pierre, Newton, Richard, Ning, Zheng, De Niz, Carlos, Oliva, Baldo, Olsen, Catharina, Palmeri, Antonio, Panesar, Bhawan, Papadopoulos, Stavros, Park, Jaesub, Park, Seonyeong, Park, Sungjoon, Pawitan, Yudi, Peluso, Daniele, Pendyala, Sriram, Peng, Jian, Perfetto, Livia, Pirro, Stefano, Plevritis, Sylvia, Politi, Regina, Poon, Hoifung, Porta, Eduard, Prellner, Isak, Preuer, Kristina, Angel Pujana, Miguel, Ramnarine, Ricardo, Reid, John E., Reyal, Fabien, Richardson, Sylvia, Ricketts, Camir, Rieswijk, Linda, Rocha, Miguel, Rodriguez-Gonzalvez, Carmen, Roell, Kyle, Rotroff, Daniel, de Ruiter, Julian R., Rukawa, Ploy, Sadacca, Benjamin, Safikhani, Zhaleh, Safitri, Fita, Sales-Pardo, Marta, Sauer, Sebastian, Schlichting, Moritz, Seoane, Jose A., Serra, Jordi, Shang, Ming-Mei, Sharma, Alok, Sharma, Hari, Shen, Yang, Shiga, Motoki, Shin, Moonshik, Shkedy, Ziv, Shopsowitz, Kevin, Sinai, Sam, Skola, Dylan, Smirnov, Petr, Soerensen, Izel Fourie, Soerensen, Peter, Song, Je-Hoon, Song, Sang Ok, Soufan, Othman, Spitzmueller, Andreas, Steipe, Boris, Suphavilai, Chayaporn, Tamayo, Sergio Pulido, Tamborero, David, Tang, Jing, Tanoli, Zia-ur-Rehman, Tarres-Deulofeu, Marc, Tegner, Jesper, Thommesen, Liv, Tonekaboni, Seyed Ali Madani, Tran, Hong, De Troyer, Ewoud, Truong, Amy, Tsunoda, Tatsuhiko, Turu, Gabor, Tzeng, Guang-Yo, Verbeke, Lieven, Videla, Santiago, Vis, Daniel, Voronkov, Andrey, Votis, Konstantinos, Wang, Ashley, Wang, Hong-Qiang Horace, Wang, Po-Wei, Wang, Sheng, Wang, Wei, Wang, Xiaochen, Wang, Xin, Wennerberg, Krister, Wernisch, Lorenz, Wessels, Lodewyk, van Westen, Gerard J. P., Westerman, Bart A., White, Simon Richard, Willighagen, Egon, Wurdinger, Tom, Xie, Lei, Xie, Shuilian, Xu, Hua, Yadav, Bhagwan, Yau, Christopher, Yeerna, Huwate, Yin, Jia Wei, Yu, Michael, Yu, MinHwan, Yun, So Jeong, Zakharov, Alexey, Zamichos, Alexandros, Zanin, Massimiliano, Zeng, Li, Zenil, Hector, Zhang, Frederick, Zhang, Pengyue, Zhang, Wei, Zhao, Hongyu, Zhao, Lan, Zheng, Wenjin, Zoufir, Azedine, Zucknick, Manuela, College of Engineering, Department of Industrial Engineering, Institute of Data Science, RS: FSE DACS IDS, Bioinformatica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: FHML MaCSBio, Promovendi NTM, Tero Aittokallio / Principal Investigator, Bioinformatics, Institute for Molecular Medicine Finland, Hu, Z, Fotso, DC, Menden, M, Wang, D, Mason, M, Szalai, B, Bulusu, K, Guan, Y, Yu, T, Kang, J, Jeon, M, Wolfinger, R, Nguyen, T, Zaslavskiy, M, Abante, J, Abecassis, B, Aben, N, Aghamirzaie, D, Aittokallio, T, Akhtari, F, Al-lazikani, B, Alam, T, Allam, A, Allen, C, de Almeida, M, Altarawy, D, Alves, V, Amadoz, A, Anchang, B, Antolin, A, Ash, J, Aznar, V, Ba-alawi, W, Bagheri, M, Bajic, V, Ball, G, Ballester, P, Baptista, D, Bare, C, Bateson, M, Bender, A, Bertrand, D, Wijayawardena, B, Boroevich, K, Bosdriesz, E, Bougouffa, S, Bounova, G, Brouwer, T, Bryant, B, Calaza, M, Calderone, A, Calza, S, Capuzzi, S, Carbonell-Caballero, J, Carlin, D, Carter, H, Castagnoli, L, Celebi, R, Cesareni, G, Chang, H, Chen, G, Chen, H, Cheng, L, Chernomoretz, A, Chicco, D, Cho, K, Cho, S, Choi, D, Choi, J, Choi, K, Choi, M, Cock, M, Coker, E, Cortes-Ciriano, I, Cserzo, M, Cubuk, C, Curtis, C, Daele, D, Dang, C, Dijkstra, T, Dopazo, J, Draghici, S, Drosou, A, Dumontier, M, Ehrhart, F, Eid, F, Elhefnawi, M, Elmarakeby, H, van Engelen, B, Engin, H, de Esch, I, Evelo, C, Falcao, A, Farag, S, Fernandez-Lozano, C, Fisch, K, Flobak, A, Fornari, C, Foroushani, A, Fotso, D, Fourches, D, Friend, S, Frigessi, A, Gao, F, Gao, X, Gerold, J, Gestraud, P, Ghosh, S, Gillberg, J, Godoy-Lorite, A, Godynyuk, L, Godzik, A, Goldenberg, A, Gomez-Cabrero, D, Gonen, M, de Graaf, C, Gray, H, Grechkin, M, Guimera, R, Guney, E, Haibe-Kains, B, Han, Y, Hase, T, He, D, He, L, Heath, L, Hellton, K, Helmer-Citterich, M, Hidalgo, M, Hidru, D, Hill, S, Hochreiter, S, Hong, S, Hovig, E, Hsueh, Y, Huang, J, Huang, R, Hunyady, L, Hwang, J, Hwang, T, Hwang, W, Hwang, Y, Isayev, O, Don't Walk, O, Jack, J, Jahandideh, S, Ji, J, Jo, Y, Kamola, P, Kanev, G, Karacosta, L, Karimi, M, Kaski, S, Kazanov, M, Khamis, A, Khan, S, Kiani, N, Kim, A, Kim, J, Kim, K, Kim, S, Kim, Y, Kirk, P, Kitano, H, Klambauer, G, Knowles, D, Ko, M, Kohn-Luque, A, Kooistra, A, Kuenemann, M, Kuiper, M, Kurz, C, Kwon, M, van Laarhoven, T, Laegreid, A, Lederer, S, Lee, H, Lee, J, Lee, Y, Lepp_aho, E, Lewis, R, Li, J, Li, L, Liley, J, Lim, W, Lin, C, Liu, Y, Lopez, Y, Low, J, Lysenko, A, Machado, D, Madhukar, N, Maeyer, D, Malpartida, A, Mamitsuka, H, Marabita, F, Marchal, K, Marttinen, P, Mason, D, Mazaheri, A, Mehmood, A, Mehreen, A, Michaut, M, Miller, R, Mitsopoulos, C, Modos, D, Moerbeke, M, Moo, K, Motsinger-Reif, A, Movva, R, Muraru, S, Muratov, E, Mushthofa, M, Nagarajan, N, Nakken, S, Nath, A, Neuvial, P, Newton, R, Ning, Z, Niz, C, Oliva, B, Olsen, C, Palmeri, A, Panesar, B, Papadopoulos, S, Park, J, Park, S, Pawitan, Y, Peluso, D, Pendyala, S, Peng, J, Perfetto, L, Pirro, S, Plevritis, S, Politi, R, Poon, H, Porta, E, Prellner, I, Preuer, K, Pujana, M, Ramnarine, R, Reid, J, Reyal, F, Richardson, S, Ricketts, C, Rieswijk, L, Rocha, M, Rodriguez-Gonzalvez, C, Roell, K, Rotroff, D, de Ruiter, J, Rukawa, P, Sadacca, B, Safikhani, Z, Safitri, F, Sales-Pardo, M, Sauer, S, Schlichting, M, Seoane, J, Serra, J, Shang, M, Sharma, A, Sharma, H, Shen, Y, Shiga, M, Shin, M, Shkedy, Z, Shopsowitz, K, Sinai, S, Skola, D, Smirnov, P, Soerensen, I, Soerensen, P, Song, J, Song, S, Soufan, O, Spitzmueller, A, Steipe, B, Suphavilai, C, Tamayo, S, Tamborero, D, Tang, J, Tanoli, Z, Tarres-Deulofeu, M, Tegner, J, Thommesen, L, Tonekaboni, S, Tran, H, Troyer, E, Truong, A, Tsunoda, T, Turu, G, Tzeng, G, Verbeke, L, Videla, S, Vis, D, Voronkov, A, Votis, K, Wang, A, Wang, H, Wang, P, Wang, S, Wang, W, Wang, X, Wennerberg, K, Wernisch, L, Wessels, L, van Westen, G, Westerman, B, White, S, Willighagen, E, Wurdinger, T, Xie, L, Xie, S, Xu, H, Yadav, B, Yau, C, Yeerna, H, Yin, J, Yu, M, Yun, S, Zakharov, A, Zamichos, A, Zanin, M, Zeng, L, Zenil, H, Zhang, F, Zhang, P, Zhang, W, Zhao, H, Zhao, L, Zheng, W, Zoufir, A, Zucknick, M, Jang, I, Ghazoui, Z, Ahsen, M, Vogel, R, Neto, E, Norman, T, Tang, E, Garnett, M, Veroli, G, Fawell, S, Stolovitzky, G, Guinney, J, Dry, J, Saez-Rodriguez, J, Menden, Michael P. [0000-0003-0267-5792], Mason, Mike J. [0000-0002-5652-7739], Yu, Thomas [0000-0002-5841-0198], Kang, Jaewoo [0000-0001-6798-9106], Nguyen, Tin [0000-0001-8001-9470], Ahsen, Mehmet Eren [0000-0002-4907-0427], Stolovitzky, Gustavo [0000-0002-9618-2819], Guinney, Justin [0000-0003-1477-1888], Saez-Rodriguez, Julio [0000-0002-8552-8976], Apollo - University of Cambridge Repository, Menden, Michael P [0000-0003-0267-5792], Mason, Mike J [0000-0002-5652-7739], Pathology, CCA - Cancer biology and immunology, Medical oncology laboratory, Neurosurgery, Chemistry and Pharmaceutical Sciences, AIMMS, Medicinal chemistry, Universidade do Minho, Department of Computer Science, Professorship Marttinen P., Aalto-yliopisto, and Aalto University
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Drug Resistance ,02 engineering and technology ,13 ,PATHWAY ,Antineoplastic Combined Chemotherapy Protocols ,Molecular Targeted Therapy ,Càncer ,lcsh:Science ,media_common ,Cancer ,Tumor ,Settore BIO/18 ,Settore BIO/11 ,Drug combinations ,High-throughput screening ,Drug Synergism ,purl.org/becyt/ford/1.2 [https] ,Genomics ,Machine Learning ,predictions ,3. Good health ,ddc ,Technologie de l'environnement, contrôle de la pollution ,Benchmarking ,5.1 Pharmaceuticals ,Cancer treatment ,Farmacogenètica ,Science & Technology - Other Topics ,Development of treatments and therapeutic interventions ,0210 nano-technology ,Human ,Drug ,media_common.quotation_subject ,Science ,49/23 ,ADAM17 Protein ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,RESOURCE ,Machine learning ,Genetics ,Chimie ,Humans ,BREAST-CANCER ,CELL ,49/98 ,Science & Technology ,Antineoplastic Combined Chemotherapy Protocol ,45 ,MUTATIONS ,Computational Biology ,Androgen receptor ,Breast-cancer ,Gene ,Cell ,Inhibition ,Resistance ,Pathway ,Mutations ,Landscape ,Resource ,631/114/1305 ,medicine.disease ,Drug synergy ,49 ,030104 developmental biology ,Pharmacogenetics ,Mutation ,Ciências Médicas::Biotecnologia Médica ,lcsh:Q ,631/154/1435/2163 ,Biomarkers ,RESISTANCE ,0301 basic medicine ,ING-INF/06 - BIOINGEGNERIA ELETTRONICA E INFORMATICA ,Statistical methods ,Computer science ,General Physics and Astronomy ,Datasets as Topic ,Drug resistance ,purl.org/becyt/ford/1 [https] ,Phosphatidylinositol 3-Kinases ,Biotecnologia Médica [Ciências Médicas] ,Neoplasms ,Science and technology ,Phosphoinositide-3 Kinase Inhibitors ,Multidisciplinary ,Biomarkers, Tumor ,Cell Line, Tumor ,Drug Antagonism ,Drug Resistance, Neoplasm ,Treatment Outcome ,Pharmacogenetic ,article ,ANDROGEN RECEPTOR ,49/39 ,631/114/2415 ,021001 nanoscience & nanotechnology ,692/4028/67 ,Multidisciplinary Sciences ,317 Pharmacy ,Patient Safety ,Systems biology ,3122 Cancers ,INHIBITION ,Computational biology ,Cell Line ,medicine ,LANDSCAPE ,Physique ,Human Genome ,Data Science ,General Chemistry ,AstraZeneca-Sanger Drug Combination DREAM Consortium ,Astronomie ,GENE ,Good Health and Well Being ,Pharmacogenomics ,Genomic ,Neoplasm ,631/553 ,Phosphatidylinositol 3-Kinase - Abstract
PubMed: 31209238, The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells. © 2019, The Author(s)., National Institute for Health Research, NIHR Wellcome Trust, WT: 102696, 206194 Magyar Tudományos Akadémia, MTA Bayer 668858 PrECISE AstraZeneca, We thank the Genomics of Drug Sensitivity in Cancer and COSMIC teams at the Wellcome Trust Sanger Institute for help with the preparation of the molecular data, Denes Turei for help with Omnipath, and Katjusa Koler for help with matching drug names across combination screens. We thank AstraZeneca for funding and provision of data to the DREAM Consortium to run the challenge, and funding from the European Union Horizon 2020 research (under grant agreement No 668858 PrECISE to J.S.R.), the Joint Research Center for Computational Biomedicine (which is partially funded by Bayer AG) to J.S.R., National Institute for Health Research (NIHR) Sheffield Biomedical Research Center, Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences. M.G lab is supported by Wellcome Trust (102696 and 206194)., Competing interests: K.C.B., Z.G., G.Y.D., E.K.Y.T., S.F., and J.R.D. are AstraZeneca employees. K.C.B., Z.G., E.K.Y.T., S.F., and J.R.D. are AstraZeneca shareholders. Y.G. receives personal compensation from Eli Lilly and Company, is a shareholder of Cleerly, Inc., and Ann Arbor Algorithms, Inc. M.G. receives research funding from AstraZeneca and has performed consultancy for Sanofi. The remaining authors declare no competing interests.
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- 2019
13. State-of-the-art global models underestimate impacts from climate extremes
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Schewe, J., Gosling, S., Reyer, C., Zhao, F., Ciais, P., Elliott, J., Francois, L., Huber, V., Lotze, H., Seneviratne I, S., van Vliet, M., Vautard, R., Wada, Y., Breuer, L., Buechner, M., Carozza, D., Chang, J., Coll, M., Deryng, D., de Wit, A., Eddy, T., Folberth, C., Frieler, K., Friend, A., Gerten, D., Gudmundsson, L., Hanasaki, N., Ito, A., Khabarov, N., Kim, H., Lawrence, P., Morfopoulos, C., Mueller, C., Schmied, H., Orth, R., Ostberg, S., Pokhrel, Y., Pugh, T., Sakurai, G., Satoh, Y., Schmid, E., Stacke, T., https://orcid.org/0000-0003-4637-5337, Steenbeek, J., Steinkamp, J., Tang, Q., Tian, H., Tittensor, D., Volkholz, J., Wang, X., Warszawski, L., Potsdam-Institut für Klimafolgenforschung (PIK), University of Nottingham, UK (UON), Potsdam Institute for Climate Impact Research (PIK), East China Normal University [Shangaï] (ECNU), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ICOS-ATC (ICOS-ATC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Chicago, Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Dalhousie University [Halifax], Institute for Atmospheric and Climate Science [Zürich] (IAC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Wageningen University and Research [Wageningen] (WUR), Extrèmes : Statistiques, Impacts et Régionalisation (ESTIMR), International Institute for Applied Systems Analysis [Laxenburg] (IIASA), Inst Landscape Ecol & Resources Management, Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Université du Québec à Montréal = University of Québec in Montréal (UQAM), MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Tyndall Centre for Climate Change Research, University of East Anglia [Norwich] (UEA), Wageningen University and Research Centre (WUR), Department of Geography, University of Liverpool, Centre National de la Recherche Scientifique (CNRS), Department of Geosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), National Institute for Environmental Studies (NIES), Institute of Industrial Science (IIS), The University of Tokyo (UTokyo), Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), Université Jean Monnet - Saint-Étienne (UJM), Goethe-Universität Frankfurt am Main, Department of Civil and Environmental Engineering [Ann Arbor] (CEE), University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Institute for Meteorology and Climate Research (IMK), Karlsruhe Institute of Technology (KIT), Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Helmholtz-Zentrum Geesthacht (GKSS), Ecopath International Initiative Research Association, Shandong Agricultural University (SDAU), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Justus-Liebig-Universität Gießen (JLU), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD), Université Jean Monnet [Saint-Étienne] (UJM), Universität für Bodenkultur Wien [Vienne, Autriche] (BOKU), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Schewe, Jacob [0000-0001-9455-4159], Gosling, Simon N [0000-0001-5973-6862], Ciais, Philippe [0000-0001-8560-4943], Lotze, Heike K [0000-0001-6258-1304], Seneviratne, Sonia I [0000-0001-9528-2917], van Vliet, Michelle TH [0000-0002-2597-8422], Vautard, Robert [0000-0001-5544-9903], Wada, Yoshihide [0000-0003-4770-2539], Breuer, Lutz [0000-0001-9720-1076], Carozza, David A [0000-0001-7343-9442], Chang, Jinfeng [0000-0003-4463-7778], Coll, Marta [0000-0001-6235-5868], de Wit, Allard [0000-0002-5517-6404], Eddy, Tyler D [0000-0002-2833-9407], Folberth, Christian [0000-0002-6738-5238], Gerten, Dieter [0000-0002-6214-6991], Gudmundsson, Lukas [0000-0003-3539-8621], Hanasaki, Naota [0000-0002-5092-7563], Ito, Akihiko [0000-0001-5265-0791], Khabarov, Nikolay [0000-0001-5372-4668], Kim, Hyungjun [0000-0003-1083-8416], Lawrence, Peter [0000-0002-4843-4903], Müller, Christoph [0000-0002-9491-3550], Müller Schmied, Hannes [0000-0001-5330-9923], Ostberg, Sebastian [0000-0002-2368-7015], Pokhrel, Yadu [0000-0002-1367-216X], Steenbeek, Jeroen [0000-0002-7878-8075], Steinkamp, Jörg [0000-0002-7861-8789], Tang, Qiuhong [0000-0002-0886-6699], Tian, Hanqin [0000-0002-1806-4091], Apollo - University of Cambridge Repository, European Commission, and Federal Ministry of Education and Research (Germany)
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Earth Observation and Environmental Informatics ,WIMEK ,0602 Ecology ,[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology ,Science ,Aardobservatie en omgevingsinformatica ,Life Science ,Water Systems and Global Change ,lcsh:Q ,PE&RC ,lcsh:Science ,Article - Abstract
14 pages, 6 figures, supplementary information .-- Data availability. Simulation data from gridded impact models is available through https://esg.pik-potsdam.de/projects/isimip2a/ and citable using the following DOIs: https://doi.org/10.5880/PIK.2017.002 (terrestrial ecosystems); https://doi.org/10.5880/PIK.2017.006 (agriculture); https://doi.org/10.5880/PIK.2017.010 (hydrology); https://doi.org/10.5880/PIK.2018.004 (marine ecosystems, regional); https://doi.org/10.5880/PIK.2018.005 (marine ecosystems, global). The city-level mortality model data and country-level hydropower model data are available from the authors upon request, Global impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first time, systematically across many important systems, how well such impact models capture the impacts of extreme climate conditions. Using the 2003 European heat wave and drought as a historical analogue for comparable events in the future, we find that a majority of models underestimate the extremeness of impacts in important sectors such as agriculture, terrestrial ecosystems, and heat-related human mortality, while impacts on water resources and hydropower are overestimated in some river basins; and the spread across models is often large. This has important implications for economic assessments of climate change impacts that rely on these models. It also means that societal risks from future extreme events may be greater than previously thought, The work was supported within the framework of the Leibniz Competition (SAW-2013-PIK-5), the EU FP7 project HELIX (grant no. FP7–603864–2), the FP7 project IMPACT2C (grant agreement#282746) and by the German Federal Ministry of Education and Research (BMBF, grant no. 01LS1201A1)
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- 2019
14. Left dorsolateral prefrontal cortex supports context-dependent prioritisation of off-task thought
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Turnbull, A., primary, Wang, H. T., additional, Murphy, C., additional, Ho, N. S. P., additional, Wang, X., additional, Sormaz, M., additional, Karapanagiotidis, T., additional, Leech, R. M., additional, Bernhardt, B., additional, Margulies, D. S., additional, Vatansever, D., additional, Jefferies, E., additional, and Smallwood, J., additional
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- 2019
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15. k-space imaging of anisotropic 2D electron gas in GaN/GaAlN high-electron-mobility transistor heterostructures
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Lev, L. L., primary, Maiboroda, I. O., additional, Husanu, M.-A., additional, Grichuk, E. S., additional, Chumakov, N. K., additional, Ezubchenko, I. S., additional, Chernykh, I. A., additional, Wang, X., additional, Tobler, B., additional, Schmitt, T., additional, Zanaveskin, M. L., additional, Valeyev, V. G., additional, and Strocov, V. N., additional
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- 2018
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16. Publisher Correction: Beyond a phenomenological description of magnetostriction
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Reid, A. H., primary, Shen, X., additional, Maldonado, P., additional, Chase, T., additional, Jal, E., additional, Granitzka, P. W., additional, Carva, K., additional, Li, R. K., additional, Li, J., additional, Wu, L., additional, Vecchione, T., additional, Liu, T., additional, Chen, Z., additional, Higley, D. J., additional, Hartmann, N., additional, Coffee, R., additional, Wu, J., additional, Dakowski, G. L., additional, Schlotter, W. F., additional, Ohldag, H., additional, Takahashi, Y. K., additional, Mehta, V., additional, Hellwig, O., additional, Fry, A., additional, Zhu, Y., additional, Cao, J., additional, Fullerton, E. E., additional, Stöhr, J., additional, Oppeneer, P. M., additional, Wang, X. J., additional, and Dürr, H. A., additional
- Published
- 2018
- Full Text
- View/download PDF
17. Observing electron localization in a dissociating H2+ molecule in real time
- Author
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Xu, H., primary, Li, Zhichao, additional, He, Feng, additional, Wang, X., additional, Atia-Tul-Noor, A., additional, Kielpinski, D., additional, Sang, R. T., additional, and Litvinyuk, I. V., additional
- Published
- 2017
- Full Text
- View/download PDF
18. Voltage-controlled interlayer coupling in perpendicularly magnetized magnetic tunnel junctions
- Author
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Newhouse-Illige, T., primary, Liu, Yaohua, additional, Xu, M., additional, Reifsnyder Hickey, D., additional, Kundu, A., additional, Almasi, H., additional, Bi, Chong, additional, Wang, X., additional, Freeland, J. W., additional, Keavney, D. J., additional, Sun, C. J., additional, Xu, Y. H., additional, Rosales, M., additional, Cheng, X. M., additional, Zhang, Shufeng, additional, Mkhoyan, K. A., additional, and Wang, W. G., additional
- Published
- 2017
- Full Text
- View/download PDF
19. Hidden amorphous phase and reentrant supercooled liquid in Pd-Ni-P metallic glasses
- Author
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Lan, S., primary, Ren, Y., additional, Wei, X. Y., additional, Wang, B., additional, Gilbert, E. P., additional, Shibayama, T., additional, Watanabe, S., additional, Ohnuma, M., additional, and Wang, X. -L., additional
- Published
- 2017
- Full Text
- View/download PDF
20. Electronic phase separation at the LaAlO3/SrTiO3 interface
- Author
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Ariando, A., Wang, X., Baskaran, G., Liu, Z.Q., Huijben, J., Yi, J.B., Annadi, A., Barman, A. Roy, Rusydi, A., Dhar, S., Feng, Y.P., Ding, J., Hilgenkamp, Johannes W.M., Venkatesan, T., Interfaces and Correlated Electron Systems, and Faculty of Science and Technology
- Subjects
Condensed Matter::Materials Science ,Multidisciplinary ,Complex oxide ,Materials science ,Condensed matter physics ,Interface (Java) ,General Physics and Astronomy ,Condensed Matter::Strongly Correlated Electrons ,General Chemistry ,Laalo3 srtio3 ,METIS-280329 ,IR-104385 ,General Biochemistry, Genetics and Molecular Biology - Abstract
There are many electronic and magnetic properties exhibited by complex oxides. Electronic phase separation (EPS) is one of those, the presence of which can be linked to exotic behaviours, such as colossal magnetoresistance, metal–insulator transition and high-temperature superconductivity. A variety of new and unusual electronic phases at the interfaces between complex oxides, in particular between two non-magnetic insulators LaAlO3 and SrTiO3, have stimulated the oxide community. However, no EPS has been observed in this system despite a theoretical prediction. Here, we report an EPS state at the LaAlO3/SrTiO3 interface, where the interface charges are separated into regions of a quasi-two-dimensional electron gas, a ferromagnetic phase, which persists above room temperature, and a (superconductor like) diamagnetic/paramagnetic phase below 60 K. The EPS is due to the selective occupancy (in the form of 2D-nanoscopic metallic droplets) of interface sub-bands of the nearly degenerate Ti orbital in the SrTiO3. The observation of this EPS demonstrates the electronic and magnetic phenomena that can emerge at the interface between complex oxides mediated by the Ti orbital.
- Published
- 2011
21. Quantum dynamics of CO–H2 in full dimensionality
- Author
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Yang, Benhui, primary, Zhang, P., additional, Wang, X., additional, Stancil, P.C., additional, Bowman, J.M., additional, Balakrishnan, N., additional, and Forrey, R.C., additional
- Published
- 2015
- Full Text
- View/download PDF
22. Observation of strong electron pairing on bands without Fermi surfaces in LiFe1−xCoxAs
- Author
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Miao, H., primary, Qian, T., additional, Shi, X., additional, Richard, P., additional, Kim, T. K., additional, Hoesch, M., additional, Xing, L. Y., additional, Wang, X.-C., additional, Jin, C.-Q., additional, Hu, J.-P., additional, and Ding, H., additional
- Published
- 2015
- Full Text
- View/download PDF
23. New diluted ferromagnetic semiconductor with Curie temperature up to 180 K and isostructural to the ‘122’ iron-based superconductors
- Author
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Zhao, K., primary, Deng, Z., additional, Wang, X. C., additional, Han, W., additional, Zhu, J. L., additional, Li, X., additional, Liu, Q. Q., additional, Yu, R. C., additional, Goko, T., additional, Frandsen, B., additional, Liu, Lian, additional, Ning, Fanlong, additional, Uemura, Y. J., additional, Dabkowska, H., additional, Luke, G. M., additional, Luetkens, H., additional, Morenzoni, E., additional, Dunsiger, S. R., additional, Senyshyn, A., additional, Böni, P., additional, and Jin, C. Q., additional
- Published
- 2013
- Full Text
- View/download PDF
24. Observing electron localization in a dissociating H2+ molecule in real time.
- Author
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Xu, H., Li, Zhichao, He, Feng, Wang, X., Atia-Tul-Noor, A., Kielpinski, D., Sang, R. T., and Litvinyuk, I. V.
- Abstract
Dissociation of diatomic molecules with odd number of electrons always causes the unpaired electron to localize on one of the two resulting atomic fragments. In the simplest diatomic molecule H
2 + dissociation yields a hydrogen atom and a proton with the sole electron ending up on one of the two nuclei. That is equivalent to breaking of a chemical bond-the most fundamental chemical process. Here we observe such electron localization in real time by performing a pump-probe experiment. We demonstrate that in H2 + electron localization is complete in just 15 fs when the molecule's internuclear distance reaches 8 atomic units. The measurement is supported by a theoretical simulation based on numerical solution of the time-dependent Schrödinger equation. This observation advances our understanding of detailed dynamics of molecular dissociation. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
25. Long-range magnetic coupling across a polar insulating layer.
- Author
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Lü, W. M., Saha, Surajit, Wang, X. Renshaw, Liu, Z. Q., Gopinadhan, K., Annadi, A., Zeng, S. W., Huang, Z., Bao, B. C., Cong, C. X., Venkatesan, M., Yu, T., Coey, J. M. D., Ariando, and Venkatesan, T.
- Published
- 2016
- Full Text
- View/download PDF
26. Quantum dynamics of CO-H2 in full dimensionality.
- Author
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Yang, Benhui, Zhang, P., Wang, X., Stancil, P.C., Bowman, J.M., Balakrishnan, N., and Forrey, R.C.
- Published
- 2015
- Full Text
- View/download PDF
27. Observation of strong electron pairing on bands without Fermi surfaces in LiFe1−xCoxAs.
- Author
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Miao, H., Qian, T., Shi, X., Richard, P., Kim, T. K., Hoesch, M., Xing, L. Y., Wang, X.-C., Jin, C.-Q., Hu, J.-P., and Ding, H.
- Published
- 2015
- Full Text
- View/download PDF
28. Anisotropic two-dimensional electron gas at the LaAlO3/SrTiO3 (110) interface.
- Author
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Annadi, A., Zhang, Q., Renshaw Wang, X., Tuzla, N., Gopinadhan, K., Lü, W. M., Roy Barman, A., Liu, Z. Q., Srivastava, A., Saha, S., Zhao, Y. L., Zeng, S. W., Dhar, S., Olsson, E., Gu, B., Yunoki, S., Maekawa, S., Hilgenkamp, H., Venkatesan, T., and Ariando
- Abstract
The observation of a high-mobility two-dimensional electron gas between two insulating complex oxides, especially LaAlO
3 /SrTiO3 , has enhanced the potential of oxides for electronics. The occurrence of this conductivity is believed to be driven by polarization discontinuity, leading to an electronic reconstruction. In this scenario, the crystal orientation has an important role and no conductivity would be expected, for example, for the interface between LaAlO3 and (110)-oriented SrTiO3 , which should not have a polarization discontinuity. Here we report the observation of unexpected conductivity at the LaAlO3 /SrTiO3 interface prepared on (110)-oriented SrTiO3 , with a LaAlO3 -layer thickness-dependent metal-insulator transition. Density functional theory calculation reveals that electronic reconstruction, and thus conductivity, is still possible at this (110) interface by considering the energetically favourable (110) interface structure, that is, buckled TiO2 /LaO, in which the polarization discontinuity is still present. The conductivity was further found to be strongly anisotropic along the different crystallographic directions with potential for anisotropic superconductivity and magnetism, leading to possible new physics and applications. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
29. New diluted ferromagnetic semiconductor with Curie temperature up to 180?K and isostructural to the '122' iron-based superconductors.
- Author
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Zhao, K., Deng, Z., Wang, X. C., Han, W., Zhu, J. L., Li, X., Liu, Q. Q., Yu, R. C., Goko, T., Frandsen, B., Liu, Lian, Ning, Fanlong, Uemura, Y. J., Dabkowska, H., Luke, G. M., Luetkens, H., Morenzoni, E., Dunsiger, S. R., Senyshyn, A., and Böni, P.
- Abstract
Diluted magnetic semiconductors have received much attention due to their potential applications for spintronics devices. A prototypical system (Ga,Mn)As has been widely studied since the 1990s. The simultaneous spin and charge doping via hetero-valent (Ga
3+ ,Mn2+ ) substitution, however, resulted in severely limited solubility without availability of bulk specimens. Here we report the synthesis of a new diluted magnetic semiconductor (Ba1?x Kx )(Zn1?y Mny )2 As2 , which is isostructural to the 122 iron-based superconductors with the tetragonal ThCr2 Si2 (122) structure. Holes are doped via (Ba2+ , K1+ ) replacements, while spins via isovalent (Zn2+ ,Mn2+ ) substitutions. Bulk samples with x=0.1?0.3 and y=0.05?0.15 exhibit ferromagnetic order with TC up to 180?K, which is comparable to the highest TC for (Ga,Mn)As and significantly enhanced from TC up to 50?K of the '111'-based Li(Zn,Mn)As. Moreover, ferromagnetic (Ba,K)(Zn,Mn)2 As2 shares the same 122 crystal structure with semiconducting BaZn2 As2 , antiferromagnetic BaMn2 As2 and superconducting (Ba,K)Fe2 As2 , which makes them promising for the development of multilayer functional devices. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
30. Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
- Author
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Joseph A. Hill, Xuliang Wang, Nan Jiang, Soo Young Kim, Stephen B. Spurgin, Hande Piristine, Sergio Lavandero, Kristin M. French, Vlad G. Zaha, Francisco Altamirano, Subhajit Dasgupta, Anwarul Ferdous, Theodore M. Hill, Herman I. May, Thomas G. Gillette, Maayan Waldman, Dan Tong, Gabriele G. Schiattarella, Heesoo Yoo, Yuxuan Luo, Elisa Villalobos, Schiattarella, G. G., Altamirano, F., Kim, S. Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K. M., Villalobos, E., Spurgin, S. B., Waldman, M., Jiang, N., May, H. I., Hill, T. M., Luo, Y., Yoo, H., Zaha, V. G., Lavandero, S., Gillette, T. G., and Hill, J. A.
- Subjects
0301 basic medicine ,X-Box Binding Protein 1 ,Ubiquitin-Protein Ligase ,Transcription, Genetic ,General Physics and Astronomy ,FOXO1 ,030204 cardiovascular system & hematology ,Heart Ventricle ,Mice ,0302 clinical medicine ,Ubiquitin ,HEK293 Cell ,Myocytes, Cardiac ,Proteolysi ,Conserved Sequence ,Multidisciplinary ,biology ,Chemistry ,Forkhead Box Protein O1 ,Protein Stability ,Cell biology ,Ubiquitin ligase ,Phenotype ,Cell signalling ,Human ,Heart Ventricles ,Ubiquitin-Protein Ligases ,Science ,Models, Biological ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,medicine ,Animals ,Humans ,Transcription factor ,STUB1 ,Heart Failure ,Binding Sites ,Base Sequence ,Animal ,Myocardium ,Binding Site ,Stroke Volume ,General Chemistry ,medicine.disease ,Lipid Metabolism ,Myocardial Contraction ,Mice, Inbred C57BL ,HEK293 Cells ,030104 developmental biology ,Cardiovascular and Metabolic Diseases ,Heart failure ,Proteolysis ,biology.protein ,Unfolded protein response ,Heart failure with preserved ejection fraction ,Gene Deletion - Abstract
Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations and perturbations in lipid homeostasis in HFpEF are largely unknown. Here, we report that cardiomyocyte steatosis in HFpEF is coupled with increases in the activity of the transcription factor FoxO1 (Forkhead box protein O1). FoxO1 depletion, as well as over-expression of the Xbp1s (spliced form of the X-box-binding protein 1) arm of the UPR (unfolded protein response) in cardiomyocytes each ameliorates the HFpEF phenotype in mice and reduces myocardial lipid accumulation. Mechanistically, forced expression of Xbp1s in cardiomyocytes triggers ubiquitination and proteasomal degradation of FoxO1 which occurs, in large part, through activation of the E3 ubiquitin ligase STUB1 (STIP1 homology and U-box-containing protein 1) a novel and direct transcriptional target of Xbp1s. Our findings uncover the Xbp1s-FoxO1 axis as a pivotal mechanism in the pathogenesis of cardiometabolic HFpEF and unveil previously unrecognized mechanisms whereby the UPR governs metabolic alterations in cardiomyocytes., Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes.
- Published
- 2021
31. Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance.
- Author
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Wu C, Wang X, Li Y, Zhen W, Wang C, Wang X, Xie Z, Xu X, Guo S, Botella JR, Zheng B, Wang W, Song CP, and Hu Z
- Subjects
- Stress Granules metabolism, Stress Granules genetics, RNA, Plant metabolism, RNA, Plant genetics, Thermotolerance genetics, RNA, Circular metabolism, RNA, Circular genetics, Plants, Genetically Modified, Arabidopsis genetics, Arabidopsis metabolism, Arabidopsis Proteins metabolism, Arabidopsis Proteins genetics, Heat-Shock Response genetics, Introns genetics, Gene Expression Regulation, Plant, RNA Splicing
- Abstract
Heat stress (HS) poses a significant challenge to plant survival, necessitating sophisticated molecular mechanisms to maintain cellular homeostasis. Here, we identify SICKLE (SIC) as a key modulator of HS responses in Arabidopsis (Arabidopsis thaliana). SIC is required for the sequestration of RNA DEBRANCHING ENZYME 1 (DBR1), a rate-limiting enzyme of lariat intronic RNA (lariRNA) decay, into stress granules (SGs). The sequestration of DBR1 by SIC enhances the accumulation of lariRNAs, branched circular RNAs derived from excised introns during pre-mRNA splicing, which in turn promote the transcription of their parental genes. Our findings further demonstrate that SIC-mediated DBR1 sequestration in SGs is crucial for plant HS tolerance, as deletion of the N-terminus of SIC (SIC
1-244 ) impairs DBR1 sequestration and compromises plant response to HS. Overall, our study unveils a mechanism of transcriptional regulation in the HS response, where lariRNAs are enriched through DBR1 sequestration, ultimately promoting the transcription of heat stress tolerance genes., (© 2024. The Author(s).)- Published
- 2024
- Full Text
- View/download PDF
32. Yeast EndoG prevents genome instability by degrading extranuclear DNA species.
- Author
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Yu Y, Wang X, Fox J, Yu R, Thakre P, McCauley B, Nikoloutsos N, Yu Y, Li Q, Hastings PJ, Dang W, Chen K, and Ira G
- Subjects
- Cell Nucleus metabolism, Cell Nucleus genetics, DNA End-Joining Repair, DNA Breaks, Double-Stranded, Meiosis genetics, Endodeoxyribonucleases metabolism, Endodeoxyribonucleases genetics, Genomic Instability, DNA, Mitochondrial genetics, DNA, Mitochondrial metabolism, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins metabolism, Saccharomyces cerevisiae Proteins genetics, Retroelements genetics
- Abstract
In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm are degraded by nucleases to prevent sterile inflammation. It remains unknown whether degradation of these DNA also prevents nuclear genome instability. We used an amplicon sequencing-based method in yeast enabling analysis of millions of DSB repair products. In non-dividing stationary phase cells, Pol4-mediated non-homologous end-joining increases, resulting in frequent insertions of 1-3 nucleotides, and insertions of mtDNA (NUMTs) or retrotransposon cDNA. Yeast EndoG (Nuc1) nuclease limits insertion of cDNA and transfer of very long mtDNA ( >10 kb) to the nucleus, where it forms unstable circles, while promoting the formation of short NUMTs (~45-200 bp). Nuc1 also regulates transfer of extranuclear DNA to nucleus in aging or meiosis. We propose that Nuc1 preserves genome stability by degrading retrotransposon cDNA and long mtDNA, while short NUMTs originate from incompletely degraded mtDNA. This work suggests that nucleases eliminating extranuclear DNA preserve genome stability., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
33. Electrosynthesis of adipic acid with high faradaic efficiency within a wide potential window.
- Author
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Liu X, Zhu YQ, Li J, Wang Y, Shi Q, Li AZ, Ji K, Wang X, Zhao X, Zheng J, and Duan H
- Abstract
Electrosynthesis of adipic acid (a precursor for nylon-66) from KA oil (a mixture of cyclohexanone and cyclohexanol) represents a sustainable strategy to replace conventional method that requires harsh conditions. However, its industrial possibility is greatly restricted by the low current density and competitive oxygen evolution reaction. Herein, we modify nickel layered double hydroxide with vanadium to promote current density and maintain high faradaic efficiency (>80%) within a wide potential window (1.5 ~ 1.9 V vs. reversible hydrogen electrode). Experimental and theoretical studies reveal two key roles of V modification, including accelerating catalyst reconstruction and strengthening cyclohexanone adsorption. As a proof-of-the-concept, we construct a membrane electrode assembly, producing adipic acid with high faradaic efficiency (82%) and productivity (1536 μmol cm
-2 h-1 ) at industrially relevant current density (300 mA cm-2 ), while achieving >50 hours stability. This work demonstrates an efficient catalyst for adipic acid electrosynthesis with high productivity that shows industrial potential., (© 2024. The Author(s).)- Published
- 2024
- Full Text
- View/download PDF
34. Pathway decisions for reuse and recycling of retired lithium-ion batteries considering economic and environmental functions.
- Author
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Ma R, Tao S, Sun X, Ren Y, Sun C, Ji G, Xu J, Wang X, Zhang X, Wu Q, and Zhou G
- Abstract
Reuse and recycling of retired electric vehicle (EV) batteries offer a sustainable waste management approach but face decision-making challenges. Based on the process-based life cycle assessment method, we present a strategy to optimize pathways of retired battery treatments economically and environmentally. The strategy is applied to various reuse scenarios with capacity configurations, including energy storage systems, communication base stations, and low-speed vehicles. Hydrometallurgical, pyrometallurgical, and direct recycling considering battery residual values are evaluated at the end-of-life stage. For the optimized pathway, lithium iron phosphate (LFP) batteries improve profits by 58% and reduce emissions by 18% compared to hydrometallurgical recycling without reuse. Lithium nickel manganese cobalt oxide (NMC) batteries boost profit by 19% and reduce emissions by 18%. Despite NMC batteries exhibiting higher immediate recycling returns, LFP batteries provide superior long-term benefits through reuse before recycling. Our strategy features an accessible evaluation framework for pinpointing optimal pathways of retired EV batteries., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
35. Room-temperature ferroelectric, piezoelectric and resistive switching behaviors of single-element Te nanowires.
- Author
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Zhang J, Zhang J, Qi Y, Gong S, Xu H, Liu Z, Zhang R, Sadi MA, Sychev D, Zhao R, Yang H, Wu Z, Cui D, Wang L, Ma C, Wu X, Gao J, Chen YP, Wang X, and Jiang Y
- Abstract
Ferroelectrics are essential in memory devices for multi-bit storage and high-density integration. Ferroelectricity mainly exists in compounds but rare in single-element materials due to their lack of spontaneous polarization in the latter. However, we report a room-temperature ferroelectricity in quasi-one-dimensional Te nanowires. Piezoelectric characteristics, ferroelectric loops and domain reversals are clearly observed. We attribute the ferroelectricity to the ion displacement created by the interlayer interaction between lone-pair electrons. Ferroelectric polarization can induce a strong field effect on the transport along the Te chain, giving rise to a self-gated ferroelectric field-effect transistor. By utilizing ferroelectric Te nanowire as channel, the device exhibits high mobility (~220 cm
2 ·V-1 ·s-1 ), continuous-variable resistive states can be observed with long-term retention (>105 s), fast speed (<20 ns) and high-density storage (>1.92 TB/cm2 ). Our work provides opportunities for single-element ferroelectrics and advances practical applications such as ultrahigh-density data storage and computing-in-memory devices., (© 2024. The Author(s).)- Published
- 2024
- Full Text
- View/download PDF
36. Exploring the dynamic evolution of lattice oxygen on exsolved-Mn 2 O 3 @SmMn 2 O 5 interfaces for NO Oxidation.
- Author
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Wang X, Yang Q, Li X, Li Z, Gao C, Zhang H, Chu X, Redshaw C, Shi S, Wu YA, Ma Y, Peng Y, Li J, and Feng S
- Abstract
Lattice oxygen in metal oxides plays an important role in the reaction of diesel oxidation catalysts, but the atomic-level understanding of structural evolution during the catalytic process remains elusive. Here, we develop a Mn
2 O3 /SmMn2 O5 catalyst using a non-stoichiometric exsolution method to explore the roles of lattice oxygen in NO oxidation. The enhanced covalency of Mn-O bond and increased electron density at Mn3+ sites, induced by the interface between exsolved Mn2 O3 and mullite, lead to the formation of highly active lattice oxygen adjacent to Mn3+ sites. Near-ambient pressure X-ray photoelectron and absorption spectroscopies show that the activated lattice oxygen enables reversible changes in Mn valence states and Mn-O bond covalency during redox cycles, reducing energy barriers for NO oxidation and promoting NO2 desorption via the cooperative Mars-van Krevelen mechanism. Therefore, the Mn2 O3 /SmMn2 O5 exhibits higher NO oxidation activity and better resistance to hydrothermal aging compared to a commercial Pt/Al2 O3 catalyst., (© 2024. The Author(s).)- Published
- 2024
- Full Text
- View/download PDF
37. SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis.
- Author
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Zhao W, Wang X, Han L, Zhang C, Wang C, Kong D, Zhang M, Xu T, Li G, Hu G, Luo J, Yee SW, Yang J, Stahl A, Chen X, and Zhang Y
- Subjects
- Animals, Humans, Male, Mice, Amino Acid Transport System y+ metabolism, Amino Acid Transport System y+ genetics, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular pathology, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Glutathione metabolism, Large Neutral Amino Acid-Transporter 1, Leucine metabolism, Proto-Oncogene Proteins c-myc metabolism, Proto-Oncogene Proteins c-myc genetics, TOR Serine-Threonine Kinases metabolism, Wnt Signaling Pathway, beta Catenin metabolism, beta Catenin genetics, Liver Neoplasms metabolism, Liver Neoplasms genetics, Liver Neoplasms pathology
- Abstract
Activated Wnt/β-catenin pathway is a key genetic event in liver cancer development. Solute carrier (SLC) transporters are promising drug targets. Here, we identify SLC13A3 as a drug-targetable effector downstream of β-catenin in liver cancer. SLC13A3 expression is elevated in human liver cancer samples with gain of function (GOF) mutant CTNNB1, the gene encoding β-catenin. Activation of β-catenin up-regulates SLC13A3, leading to intracellular accumulation of endogenous SLC13A3 substrates. SLC13A3 is identified as a low-affinity transporter for glutathione (GSH). Silencing of SLC13A3 downregulates the leucine transporter SLC7A5 via c-MYC signaling, leading to leucine depletion and mTOR inactivation. Furthermore, silencing of SLC13A3 depletes GSH and induces autophagic ferroptosis in β-catenin-activated liver cancer cells. Importantly, both genetic inhibition of SLC13A3 and a small molecule SLC13A3 inhibitor suppress β-catenin-driven hepatocarcinogenesis in mice. Altogether, our study suggests that SLC13A3 could be a promising therapeutic target for treating human liver cancers with GOF CTNNB1 mutations., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
38. RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade.
- Author
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Nokin MJ, Mira A, Patrucco E, Ricciuti B, Cousin S, Soubeyran I, San José S, Peirone S, Caizzi L, Vietti Michelina S, Bourdon A, Wang X, Alvarez-Villanueva D, Martínez-Iniesta M, Vidal A, Rodrigues T, García-Macías C, Awad MM, Nadal E, Villanueva A, Italiano A, Cereda M, Santamaría D, and Ambrogio C
- Subjects
- Humans, Animals, Mice, Cell Line, Tumor, Mutation, Female, Xenograft Model Antitumor Assays, Guanosine Triphosphate metabolism, Acetonitriles, Piperazines, Pyridines, Pyrimidines, Proto-Oncogene Proteins p21(ras) genetics, Proto-Oncogene Proteins p21(ras) antagonists & inhibitors, Proto-Oncogene Proteins p21(ras) metabolism, Drug Resistance, Neoplasm genetics, Drug Resistance, Neoplasm drug effects, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung metabolism, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms drug therapy, Lung Neoplasms genetics, Lung Neoplasms metabolism, Lung Neoplasms pathology
- Abstract
Selective KRAS
G12C inhibitors have been developed to covalently lock the oncogene in the inactive GDP-bound state. Two of these molecules, sotorasib and adagrasib, are approved for the treatment of adult patients with KRASG12C -mutated previously treated advanced non-small cell lung cancer. Drug treatment imposes selective pressures leading to the outgrowth of drug-resistant variants. Mass sequencing from patients' biopsies identified a number of acquired KRAS mutations -both in cis and in trans- in resistant tumors. We demonstrate here that disease progression in vivo can also occur due to adaptive mechanisms and increased KRAS-GTP loading. Using the preclinical tool tri-complex KRASG12C -selective covalent inhibitor, RMC-4998 (also known as RM-029), that targets the active GTP-bound (ON) state of the oncogene, we provide a proof-of-concept that the clinical stage KRASG12C (ON) inhibitor RMC-6291 alone or in combination with KRASG12C (OFF) drugs can be an alternative potential therapeutic strategy to circumvent resistance due to increased KRAS-GTP loading., (© 2024. The Author(s).)- Published
- 2024
- Full Text
- View/download PDF
39. Long-term safety and effectiveness of mRNA-1273 vaccine in adults: COVE trial open-label and booster phases.
- Author
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Baden LR, El Sahly HM, Essink B, Follmann D, Hachigian G, Strout C, Overcash JS, Doblecki-Lewis S, Whitaker JA, Anderson EJ, Neuzil K, Corey L, Priddy F, Tomassini JE, Brown M, Girard B, Stolman D, Urdaneta V, Wang X, Deng W, Zhou H, Dixit A, Das R, and Miller JM
- Subjects
- Humans, Adult, Male, Female, Middle Aged, Vaccine Efficacy, Antibodies, Viral immunology, Antibodies, Viral blood, Immunogenicity, Vaccine, Aged, Young Adult, Vaccination, Adolescent, 2019-nCoV Vaccine mRNA-1273 immunology, COVID-19 prevention & control, COVID-19 immunology, Immunization, Secondary, SARS-CoV-2 immunology, COVID-19 Vaccines immunology, COVID-19 Vaccines adverse effects, COVID-19 Vaccines administration & dosage
- Abstract
Primary vaccination with mRNA-1273 (100-µg) was safe and efficacious at preventing coronavirus disease 2019 (COVID-19) in the previously reported, blinded Part A of the phase 3 Coronavirus Efficacy (COVE; NCT04470427) trial in adults (≥18 years) across 99 U.S. sites. The open-label (Parts B and C) primary objectives were evaluation of long-term safety and effectiveness of primary vaccination plus a 50-µg booster dose; immunogenicity was a secondary objective. Of 29,035 open-label participants, 19,609 received boosters (mRNA-1273 [n = 9647]; placebo-mRNA-1273 [n = 9952]; placebo [n = 10] groups). Booster safety was consistent with that reported for primary vaccination. Incidences of COVID-19 and severe COVID-19 were higher during the Omicron BA.1 than Delta variant waves and boosting versus non-boosting was associated with a significant, 47.0% (95% CI : 39.0-53.9%) reduction of Omicron BA.1 incidence (24.6 [23.4 - 25.8] vs 46.4 [40.6 - 52.7]/1000 person-months). In an exploratory Cox regression model adjusted for time-varying covariates, a longer median interval between primary vaccination and boosting (mRNA-1273 [13 months] vs placebo-mRNA-1273 [8 months]) was associated with significantly lower, COVID-19 risk (24.0% [16.0% - 32.0%]) during Omicron BA.1 predominance. Boosting elicited greater immune responses against SARS-CoV-2 than primary vaccination, irrespective of prior SARS-CoV-2 infection. Primary vaccination and boosting with mRNA-1273 demonstrated acceptable safety, effectiveness and immunogenicity against COVID-19, including emergent variants., (© 2024. The Author(s).)
- Published
- 2024
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40. Stabilized Cu δ+ -OH species on in situ reconstructed Cu nanoparticles for CO 2 -to-C 2 H 4 conversion in neutral media.
- Author
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Wang L, Chen Z, Xiao Y, Huang L, Wang X, Fruehwald H, Akhmetzyanov D, Hanson M, Chen Z, Chen N, Billinghurst B, Smith RDL, Singh CV, Tan Z, and Wu YA
- Abstract
Achieving large-scale electrochemical CO
2 reduction to multicarbon products with high selectivity using membrane electrode assembly (MEA) electrolyzers in neutral electrolyte is promising for carbon neutrality. However, the unsatisfactory multicarbon products selectivity and unclear reaction mechanisms in an MEA have hindered its further development. Here, we report a strategy that manipulates the interfacial microenvironment of Cu nanoparticles in an MEA to suppress hydrogen evolution reaction and enhance C2 H4 conversion. In situ multimodal characterizations consistently reveal well-stabilized Cuδ+ -OH species as active sites during MEA testing. The OH radicals generated in situ from water create a locally oxidative microenvironment on the copper surface, stabilizing the Cuδ+ species and leading to an irreversible and asynchronous change in morphology and valence, yielding high-curvature nanowhiskers. Consequently, we deliver a selective C2 H4 production with a Faradaic efficiency of 55.6% ± 2.8 at 316 mA cm-2 in neutral media., (© 2024. The Author(s).)- Published
- 2024
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41. Quasi-equilibrium growth of inch-scale single-crystal monolayer α-In 2 Se 3 on fluor-phlogopite.
- Author
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Si K, Zhao Y, Zhang P, Wang X, He Q, Wei J, Li B, Wang Y, Cao A, Hu Z, Tang P, Ding F, and Gong Y
- Abstract
Epitaxial growth of two-dimensional (2D) materials with uniform orientation has been previously realized by introducing a small binding energy difference between the two locally most stable orientations. However, this small energy difference can be easily disturbed by uncontrollable dynamics during the growth process, limiting its practical applications. Herein, we propose a quasi-equilibrium growth (QEG) strategy to synthesize inch-scale monolayer α-In
2 Se3 single crystals, a semiconductor with ferroelectric properties, on fluor-phlogopite substrates. The QEG facilitates the discrimination of small differences in binding energy between the two locally most stable orientations, realizing robust single-orientation epitaxy within a broad growth window. Thus, single-crystal α-In2 Se3 film can be epitaxially grown on fluor-phlogopite, the cleavage surface atomic layer of which has the same 3-fold rotational symmetry with α-In2 Se3 . The resulting crystalline quality enables high electron mobility up to 117.2 cm2 V-1 s-1 in α-In2 Se3 ferroelectric field-effect transistors, exhibiting reliable nonvolatile memory performance with long retention time and robust cycling endurance. In brief, the developed QEG method provides a route for preparing larger-area single-crystal 2D materials and a promising opportunity for applications of 2D ferroelectric devices and nanoelectronics., (© 2024. The Author(s).)- Published
- 2024
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42. Multiferroicity in plastically deformed SrTiO 3 .
- Author
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Wang X, Kundu A, Xu B, Hameed S, Rothem N, Rabkin S, Rogić L, Thompson L, McLeod A, Greven M, Pelc D, Sochnikov I, Kalisky B, and Klein A
- Abstract
Quantum materials have a fascinating tendency to manifest novel and unexpected electronic states upon proper manipulation. Ideally, such manipulation should induce strong and irreversible changes and lead to new relevant length scales. Plastic deformation introduces large numbers of dislocations into a material, which can organize into extended structures and give rise to qualitatively new physics as a result of the huge localized strains. However, this approach is largely unexplored in the context of quantum materials, which are traditionally grown to be as pristine and clean as possible. Here we show that plastic deformation induces robust magnetism in the quantum paraelectric SrTiO
3 , a property that is completely absent in the pristine material. We combine scanning magnetic measurements and near-field optical microscopy to find that the magnetic order is localized along dislocation walls and coexists with ferroelectric order along the walls. The magnetic signals can be switched on and off via external stress and altered by external electric fields, which demonstrates that plastically deformed SrTiO3 is a quantum multiferroic. These results establish plastic deformation as a versatile knob for the manipulation of the electronic properties of quantum materials., (© 2024. The Author(s).)- Published
- 2024
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43. PTPN14 aggravates neointimal hyperplasia via boosting PDGFRβ signaling in smooth muscle cells.
- Author
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Ma Q, He X, Wang X, Zhao G, Zhang Y, Su C, Wei M, Zhang K, Liu M, Zhu Y, and He J
- Subjects
- Animals, Humans, Mice, Phosphorylation, Male, Protein Tyrosine Phosphatases, Non-Receptor metabolism, Protein Tyrosine Phosphatases, Non-Receptor genetics, Mice, Inbred C57BL, Mice, Knockout, Coronary Vessels pathology, Coronary Vessels metabolism, Muscle, Smooth, Vascular metabolism, Muscle, Smooth, Vascular pathology, Receptor, Platelet-Derived Growth Factor beta metabolism, Receptor, Platelet-Derived Growth Factor beta genetics, Hyperplasia metabolism, Myocytes, Smooth Muscle metabolism, Myocytes, Smooth Muscle pathology, Signal Transduction, Neointima metabolism, Neointima pathology
- Abstract
Smooth muscle cell (SMC) phenotypic modulation, primarily driven by PDGFRβ signaling, is implicated in occlusive cardiovascular diseases. However, the promotive and restrictive regulation mechanism of PDGFRβ and the role of protein tyrosine phosphatase non-receptor type 14 (PTPN14) in neointimal hyperplasia remain unclear. Our study observes a marked upregulation of PTPN14 in SMCs during neointimal hyperplasia. PTPN14 overexpression exacerbates neointimal hyperplasia in a phosphatase activity-dependent manner, while SMC-specific deficiency of PTPN14 mitigates this process in mice. RNA-seq indicates that PTPN14 deficiency inhibits PDGFRβ signaling-induced SMC phenotypic modulation. Moreover, PTPN14 interacts with intracellular region of PDGFRβ and mediates its dephosphorylation on Y692 site. Phosphorylation of PDGFRβ
Y692 negatively regulates PDGFRβ signaling activation. The levels of both PTPN14 and phospho-PDGFRβY692 are correlated with the degree of stenosis in human coronary arteries. Our findings suggest that PTPN14 serves as a critical modulator of SMCs, promoting neointimal hyperplasia. PDGFRβY692 , dephosphorylated by PTPN14, acts as a self-inhibitory site for controlling PDGFRβ activation., (© 2024. The Author(s).)- Published
- 2024
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44. Multi-modal deep learning enables efficient and accurate annotation of enzymatic active sites.
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Wang X, Yin X, Jiang D, Zhao H, Wu Z, Zhang O, Wang J, Li Y, Deng Y, Liu H, Luo P, Han Y, Hou T, Yao X, and Hsieh CY
- Subjects
- Databases, Protein, Molecular Sequence Annotation methods, Computational Biology methods, Deep Learning, Catalytic Domain, Enzymes metabolism, Enzymes chemistry, Algorithms
- Abstract
Annotating active sites in enzymes is crucial for advancing multiple fields including drug discovery, disease research, enzyme engineering, and synthetic biology. Despite the development of numerous automated annotation algorithms, a significant trade-off between speed and accuracy limits their large-scale practical applications. We introduce EasIFA, an enzyme active site annotation algorithm that fuses latent enzyme representations from the Protein Language Model and 3D structural encoder, and then aligns protein-level information with the knowledge of enzymatic reactions using a multi-modal cross-attention framework. EasIFA outperforms BLASTp with a 10-fold speed increase and improved recall, precision, f1 score, and MCC by 7.57%, 13.08%, 9.68%, and 0.1012, respectively. It also surpasses empirical-rule-based algorithm and other state-of-the-art deep learning annotation method based on PSSM features, achieving a speed increase ranging from 650 to 1400 times while enhancing annotation quality. This makes EasIFA a suitable replacement for conventional tools in both industrial and academic settings. EasIFA can also effectively transfer knowledge gained from coarsely annotated enzyme databases to smaller, high-precision datasets, highlighting its ability to model sparse and high-quality databases. Additionally, EasIFA shows potential as a catalytic site monitoring tool for designing enzymes with desired functions beyond their natural distribution., (© 2024. The Author(s).)
- Published
- 2024
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45. Utilizing full-spectrum sunlight for ammonia decomposition to hydrogen over GaN nanowires-supported Ru nanoparticles on silicon.
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Li J, Sheng B, Chen Y, Yang J, Wang P, Li Y, Yu T, Pan H, Qiu L, Li Y, Song J, Zhu L, Wang X, Huang Z, and Zhou B
- Abstract
Photo-thermal-coupling ammonia decomposition presents a promising strategy for utilizing the full-spectrum to address the H
2 storage and transportation issues. Herein, we exhibit a photo-thermal-catalytic architecture by assembling gallium nitride nanowires-supported ruthenium nanoparticles on a silicon for extracting hydrogen from ammonia aqueous solution in a batch reactor with only sunlight input. The photoexcited charge carriers make a predomination contribution on H2 activity with the assistance of the photothermal effect. Upon concentrated light illumination, the architecture significantly reduces the activation energy barrier from 1.08 to 0.22 eV. As a result, a high turnover number of 3,400,750 is reported during 400 h of continuous light illumination, and the H2 activity per hour is nearly 1000 times higher than that under the pure thermo-catalytic conditions. The reaction mechanism is extensively studied by coordinating experiments, spectroscopic characterizations, and density functional theory calculation. Outdoor tests validate the viability of such a multifunctional architecture for ammonia decomposition toward H2 under natural sunlight., (© 2024. The Author(s).)- Published
- 2024
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46. The role of TIR domain-containing proteins in bacterial defense against phages.
- Author
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Wang S, Kuang S, Song H, Sun E, Li M, Liu Y, Xia Z, Zhang X, Wang X, Han J, Rao VB, Zou T, Tan C, and Tao P
- Subjects
- Escherichia coli Proteins metabolism, Escherichia coli Proteins genetics, Escherichia coli Proteins immunology, Immunity, Innate, Toll-Like Receptors metabolism, Toll-Like Receptors genetics, Toll-Like Receptors immunology, Receptors, Interleukin-1 metabolism, Receptors, Interleukin-1 genetics, Escherichia coli genetics, Escherichia coli virology, Escherichia coli immunology, Escherichia coli metabolism, Bacteriophages genetics, Bacteriophages immunology, Protein Domains
- Abstract
Toll/interleukin-1 receptor (TIR) domain-containing proteins play a critical role in immune responses in diverse organisms, but their function in bacterial systems remains to be fully elucidated. This study, focusing on Escherichia coli, addresses how TIR domain-containing proteins contribute to bacterial immunity against phage attack. Through an exhaustive survey of all E. coli genomes available in the NCBI database and testing of 32 representatives of the 90% of the identified TIR domain-containing proteins, we found that a significant proportion (37.5%) exhibit antiphage activities. These defense systems recognize a variety of phage components, thus providing a sophisticated mechanism for pathogen detection and defense. This study not only highlights the robustness of TIR systems in bacterial immunity, but also draws an intriguing parallel to the diversity seen in mammalian Toll-like receptors (TLRs), enriching our understanding of innate immune mechanisms across life forms and underscoring the evolutionary significance of these defense strategies in prokaryotes., (© 2024. The Author(s).)
- Published
- 2024
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47. 2-dimensional impact-damping electrostatic actuators with elastomer-enhanced auxetic structure.
- Author
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Wang X, Wang Y, Zhu M, and Yue X
- Abstract
Biomimetic robots yearn for compliant actuators that are comparable to biological muscle in both functions and structural properties. For that, electrostatic actuators have been developed to imitate bio-muscle in features of fast response, high power, energy-efficiency, etc. However, those actuators typically lack impact damping performance, making them vulnerable and unstable in real applications. Here, we present auxetic electrostatic actuators that address this issue and demonstrate muscle-like performance by using elastomer-enhanced auxetics and electrostatic zipping mechanism. The proposed actuators contract linearly on applied voltage, producing large actuation strength (15 N) and contraction ratio (59%). Fabricated from readily available materials, our prototypes can quickly attenuate vibrations caused by impacts and absorb shock energy in 0.3 s. Furthermore, leveraging their 2-dimensional working mode and self-locking mechanism, a stiffness-changing muscle for a robotic arm and an active tensegrity device exemplify the potential applications of auxetic electrostatic actuators to a wide range of bionic robots., (© 2024. The Author(s).)
- Published
- 2024
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48. Interpretable semi-supervised clustering enables universal detection and intensity assessment of diverse aviation hazardous winds.
- Author
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Gao H, Shen C, Wang X, Chan PW, Hon KK, and Li J
- Abstract
The identification of aviation hazardous winds is crucial and challenging in air traffic management for assuring flight safety, particularly during the take-off and landing phases. Existing criteria are typically tailored for special wind types, and whether there exists a universal feature that can effectively detect diverse types of hazardous winds from radar/lidar observations remains as an open question. Here we propose an interpretable semi-supervised clustering paradigm to solve this problem, where the prior knowledge and probabilistic models of winds are integrated to overcome the bottleneck of scarce labels (pilot reports). Based on this paradigm, a set of high-dimensional hazard features is constructed to effectively identify the occurrence of diverse hazardous winds and assess the intensity metrics. Verification of the paradigm across various scenarios has highlighted its high adaptability to diverse input data and good generalizability to diverse geographical and climate zones., (© 2024. The Author(s).)
- Published
- 2024
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49. Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy.
- Author
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Liao M, Zhu X, Lu Y, Yi X, Hu Y, Zhao Y, Ye Z, Guo X, Liang M, Jin X, Zhang H, Wang X, Zhao Z, Chen Y, and Yan H
- Subjects
- Animals, Mice, Male, Mice, Inbred C57BL, Humans, Enhancer Elements, Genetic genetics, Epigenesis, Genetic, Disease Models, Animal, Eye Injuries metabolism, Eye Injuries genetics, Eye Injuries pathology, Gene Expression Profiling, Multiomics, Vitreoretinopathy, Proliferative metabolism, Vitreoretinopathy, Proliferative genetics, Vitreoretinopathy, Proliferative pathology, Retinal Pigment Epithelium metabolism, NFATC Transcription Factors metabolism, NFATC Transcription Factors genetics, Signal Transduction
- Abstract
During the progression of proliferative vitreoretinopathy (PVR) following ocular trauma, previously quiescent retinal pigment epithelial (RPE) cells transition into a state of rapid proliferation, migration, and secretion. The elusive molecular mechanisms behind these changes have hindered the development of effective pharmacological treatments, presenting a pressing clinical challenge. In this study, by monitoring the dynamic changes in chromatin accessibility and various histone modifications, we chart the comprehensive epigenetic landscape of RPE cells in male mice subjected to traumatic PVR. Coupled with transcriptomic analysis, we reveal a robust correlation between enhancer activation and the upregulation of the PVR-associated gene programs. Furthermore, by constructing transcription factor regulatory networks, we identify the aberrant activation of enhancer-driven RANK-NFATc1 pathway as PVR advanced. Importantly, we demonstrate that intraocular interventions, including nanomedicines inhibiting enhancer activity, gene therapies targeting NFATc1 and antibody therapeutics against RANK pathway, effectively mitigate PVR progression. Together, our findings elucidate the epigenetic basis underlying the activation of PVR-associated genes during RPE cell fate transitions and offer promising therapeutic avenues targeting epigenetic modulation and the RANK-NFATc1 axis for PVR management., (© 2024. The Author(s).)
- Published
- 2024
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50. The pan-tandem repeat map highlights multiallelic variants underlying gene expression and agronomic traits in rice.
- Author
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He H, Leng Y, Cao X, Zhu Y, Li X, Yuan Q, Zhang B, He W, Wei H, Liu X, Xu Q, Guo M, Zhang H, Yang L, Lv Y, Wang X, Shi C, Zhang Z, Chen W, Zhang B, Wang T, Yu X, Qian H, Zhang Q, Dai X, Liu C, Cui Y, Wang Y, Zheng X, Xiong G, Zhou Y, Qian Q, and Shang L
- Subjects
- Chromosome Mapping, Polymorphism, Single Nucleotide, Phenotype, Genetic Variation, Oryza genetics, Oryza growth & development, Oryza metabolism, Quantitative Trait Loci, Alleles, Gene Expression Regulation, Plant, Genome, Plant, Tandem Repeat Sequences genetics
- Abstract
Tandem repeats (TRs) are genomic regions that tandemly change in repeat number, which are often multiallelic. Their characteristics and contributions to gene expression and quantitative traits in rice are largely unknown. Here, we survey rice TR variations based on 231 genome assemblies and the rice pan-genome graph. We identify 227,391 multiallelic TR loci, including 54,416 TR variations that are absent from the Nipponbare reference genome. Only 1/3 TR variations show strong linkage with nearby bi-allelic variants (SNPs, Indels and PAVs). Using 193 panicle and 202 leaf transcriptomic data, we reveal 485 and 511 TRs act as QTLs independently of other bi-allelic variations to nearby gene expression, respectively. Using plant height and grain width as examples, we identify and validate TRs contributions to rice agronomic trait variations. These findings would enhance our understanding of the functions of multiallelic variants and facilitate rice molecular breeding., (© 2024. The Author(s).)
- Published
- 2024
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- View/download PDF
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