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1. Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies

Author

Victoria O. Pokusaeva, Roshan Satapathy, Olga Symonova, and Maximilian Joesch

Subjects
Science
Abstract

Abstract Animals rely on compensatory actions to maintain stability and navigate their environment efficiently. These actions depend on global visual motion cues known as optic-flow. While the optomotor response has been the traditional focus for studying optic-flow compensation in insects, its simplicity has been insufficient to determine the role of the intricate optic-flow processing network involved in visual course control. Here, we reveal a series of course control behaviours in Drosophila and link them to specific neural circuits. We show that bilateral electrical coupling of optic-flow-sensitive neurons in the fly’s lobula plate are required for a proper course control. This electrical interaction works alongside chemical synapses within the HS-H2 network to control the dynamics and direction of turning behaviours. Our findings reveal how insects use bilateral motion cues for navigation, assigning a new functional significance to the HS-H2 network and suggesting a previously unknown role for gap junctions in non-linear operations.

Published
2024
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2. Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells

Author

Victoria O. Shender, Ksenia S. Anufrieva, Polina V. Shnaider, Georgij P. Arapidi, Marat S. Pavlyukov, Olga M. Ivanova, Irina K. Malyants, Grigory A. Stepanov, Evgenii Zhuravlev, Rustam H. Ziganshin, Ivan O. Butenko, Olga N. Bukato, Ksenia M. Klimina, Vladimir A. Veselovsky, Tatiana V. Grigorieva, Sergey Y. Malanin, Olga I. Aleshikova, Andrey V. Slonov, Nataliya A. Babaeva, Lev A. Ashrafyan, Elena Khomyakova, Evgeniy G. Evtushenko, Maria M. Lukina, Zixiang Wang, Artemiy S. Silantiev, Anna A. Nushtaeva, Daria D. Kharlampieva, Vassili N. Lazarev, Arseniy I. Lashkin, Lorine K. Arzumanyan, Irina Yu. Petrushanko, Alexander A. Makarov, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova, and Vadim M. Govorun

Subjects
Science
Abstract

Abstract Ovarian cancer often develops resistance to conventional therapies, hampering their effectiveness. Here, using ex vivo paired ovarian cancer ascites obtained before and after chemotherapy and in vitro therapy-induced secretomes, we show that molecules secreted by ovarian cancer cells upon therapy promote cisplatin resistance and enhance DNA damage repair in recipient cancer cells. Even a short-term incubation of chemonaive ovarian cancer cells with therapy-induced secretomes induces changes resembling those that are observed in chemoresistant patient-derived tumor cells after long-term therapy. Using integrative omics techniques, we find that both ex vivo and in vitro therapy-induced secretomes are enriched with spliceosomal components, which relocalize from the nucleus to the cytoplasm and subsequently into the extracellular vesicles upon treatment. We demonstrate that these molecules substantially contribute to the phenotypic effects of therapy-induced secretomes. Thus, SNU13 and SYNCRIP spliceosomal proteins promote therapy resistance, while the exogenous U12 and U6atac snRNAs stimulate tumor growth. These findings demonstrate the significance of spliceosomal network perturbation during therapy and further highlight that extracellular signaling might be a key factor contributing to the emergence of ovarian cancer therapy resistance.

Published
2024
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3. Author Correction: Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells

Author

Victoria O. Shender, Ksenia S. Anufrieva, Polina V. Shnaider, Georgij P. Arapidi, Marat S. Pavlyukov, Olga M. Ivanova, Irina K. Malyants, Grigory A. Stepanov, Evgenii Zhuravlev, Rustam H. Ziganshin, Ivan O. Butenko, Olga N. Bukato, Ksenia M. Klimina, Vladimir A. Veselovsky, Tatiana V. Grigorieva, Sergey Y. Malanin, Olga I. Aleshikova, Andrey V. Slonov, Nataliya A. Babaeva, Lev A. Ashrafyan, Elena Khomyakova, Evgeniy G. Evtushenko, Maria M. Lukina, Zixiang Wang, Artemiy S. Silantiev, Anna A. Nushtaeva, Daria D. Kharlampieva, Vassili N. Lazarev, Arseniy I. Lashkin, Lorine K. Arzumanyan, Irina Yu. Petrushanko, Alexander A. Makarov, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova, and Vadim M. Govorun

Subjects
Science
Published
2024
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4. Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

Author

Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong, and Zhaojian Liu

Subjects
Science
Abstract

Altered expression of splicing factors can contribute to tumour progression. Here the authors show that splicing factor BUD31 enhances ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12.

Published
2022
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5. Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies.

Author

Pokusaeva, Victoria O., Satapathy, Roshan, Symonova, Olga, and Joesch, Maximilian

Subjects
VISUAL perception, NEURAL circuitry, FLY control, CHEMICAL plants, NEURONS
Abstract

Animals rely on compensatory actions to maintain stability and navigate their environment efficiently. These actions depend on global visual motion cues known as optic-flow. While the optomotor response has been the traditional focus for studying optic-flow compensation in insects, its simplicity has been insufficient to determine the role of the intricate optic-flow processing network involved in visual course control. Here, we reveal a series of course control behaviours in Drosophila and link them to specific neural circuits. We show that bilateral electrical coupling of optic-flow-sensitive neurons in the fly's lobula plate are required for a proper course control. This electrical interaction works alongside chemical synapses within the HS-H2 network to control the dynamics and direction of turning behaviours. Our findings reveal how insects use bilateral motion cues for navigation, assigning a new functional significance to the HS-H2 network and suggesting a previously unknown role for gap junctions in non-linear operations. The circuitry underpinning visuomotor behaviors in flies is poorly understood. Here, the authors show that the underlying computations require bilateral electrical coupling to control turning dynamics and direction for effective course control. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells.

Author

Shender, Victoria O., Anufrieva, Ksenia S., Shnaider, Polina V., Arapidi, Georgij P., Pavlyukov, Marat S., Ivanova, Olga M., Malyants, Irina K., Stepanov, Grigory A., Zhuravlev, Evgenii, Ziganshin, Rustam H., Butenko, Ivan O., Bukato, Olga N., Klimina, Ksenia M., Veselovsky, Vladimir A., Grigorieva, Tatiana V., Malanin, Sergey Y., Aleshikova, Olga I., Slonov, Andrey V., Babaeva, Nataliya A., and Ashrafyan, Lev A.

Subjects
ASCITIC fluids, DNA repair, OVARIAN cancer, CANCER cells, EXTRACELLULAR vesicles, CANCER chemotherapy, SECRETION
Abstract

Ovarian cancer often develops resistance to conventional therapies, hampering their effectiveness. Here, using ex vivo paired ovarian cancer ascites obtained before and after chemotherapy and in vitro therapy-induced secretomes, we show that molecules secreted by ovarian cancer cells upon therapy promote cisplatin resistance and enhance DNA damage repair in recipient cancer cells. Even a short-term incubation of chemonaive ovarian cancer cells with therapy-induced secretomes induces changes resembling those that are observed in chemoresistant patient-derived tumor cells after long-term therapy. Using integrative omics techniques, we find that both ex vivo and in vitro therapy-induced secretomes are enriched with spliceosomal components, which relocalize from the nucleus to the cytoplasm and subsequently into the extracellular vesicles upon treatment. We demonstrate that these molecules substantially contribute to the phenotypic effects of therapy-induced secretomes. Thus, SNU13 and SYNCRIP spliceosomal proteins promote therapy resistance, while the exogenous U12 and U6atac snRNAs stimulate tumor growth. These findings demonstrate the significance of spliceosomal network perturbation during therapy and further highlight that extracellular signaling might be a key factor contributing to the emergence of ovarian cancer therapy resistance. Ovarian cancers frequently develop resistance to therapy. Here, using transcriptomics, proteomics, and preclinical models to analyse paired ascitic fluids before and after chemotherapy in ovarian cancer patients, the authors discover that extracellular secretion and spliceosomal components contribute to therapy resistance, enhancing the DNA damage response in recipient cancer cells. [ABSTRACT FROM AUTHOR]

Published
2024
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7. A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain

Author

Pere Gelabert, Victoria Oberreiter, Lawrence Guy Straus, Manuel Ramón González Morales, Susanna Sawyer, Ana B. Marín-Arroyo, Jeanne Marie Geiling, Florian Exler, Florian Brueck, Stefan Franz, Fernanda Tenorio Cano, Sophie Szedlacsek, Evelyn Zelger, Michelle Hämmerle, Brina Zagorc, Alejandro Llanos-Lizcano, Olivia Cheronet, José-Miguel Tejero, Thomas Rattei, Stephan M. Kraemer, and Ron Pinhasi

Subjects
Science
Abstract

Abstract Caves are primary sites for studying human and animal subsistence patterns and genetic ancestry throughout the Palaeolithic. Iberia served as a critical human and animal refugium in Europe during the Last Glacial Maximum (LGM), 26.5 to 19 thousand years before the present (cal kya). Therefore, it is a key location for understanding human and animal population dynamics during this event. We recover and analyse sedimentary ancient DNA (sedaDNA) data from the lower archaeological stratigraphic sequence of El Mirón Cave (Cantabria, Spain), encompassing the (1) Late Mousterian period, associated with Neanderthals, and (2) the Gravettian (c. 31.5 cal kya), Solutrean (c. 24.5–22 cal kya), and Initial Magdalenian (d. 21–20.5 cal kya) periods, associated with anatomically modern humans. We identify 28 animal taxa including humans. Fifteen of these taxa had not been identified from the archaeozoological (i.e., faunal) record, including the presence of hyenas in the Magdalenian. Additionally, we provide phylogenetic analyses on 70 sedaDNA mtDNA genomes of fauna including the densest Iberian Pleistocene sampling of C. lupus. Finally, we recover three human mtDNA sequences from the Solutrean levels. These sequences, along with published data, suggest mtDNA haplogroup continuity in Iberia throughout the Solutrean/Last Glacial Maximum period.

Published
2025
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9. Isotopic evidence of acetate turnover in Precambrian continental fracture fluids

Author

Elliott P. Mueller, Juliann Panehal, Alexander Meshoulam, Min Song, Christian T. Hansen, Oliver Warr, Jason Boettger, Verena B. Heuer, Wolfgang Bach, Kai-Uwe Hinrichs, John M. Eiler, Victoria Orphan, Barbara Sherwood Lollar, and Alex L. Sessions

Subjects
Science
Abstract

Abstract The deep continental crust represents a vast potential habitat for microbial life where its activity remains poorly constrained. Organic acids like acetate are common in these ecosystems, but their role in the subsurface carbon cycle - including the mechanism and rate of their turnover - is still unclear. Here, we develop an isotope-exchange ‘clock’ based on the abiotic equilibration of H-isotopes between acetate and water, which can be used to define the maximum in situ acetate residence time. We apply this technique to the fracture fluids in Birchtree and Kidd Creek mines within the Canadian Precambrian crust. At both sites, we find that acetate residence times are

Published
2024
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10. Author Correction: A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain

Author

Pere Gelabert, Victoria Oberreiter, Lawrence Guy Straus, Manuel Ramón González Morales, Susanna Sawyer, Ana B. Marín-Arroyo, Jeanne Marie Geiling, Florian Exler, Florian Brueck, Stefan Franz, Fernanda Tenorio Cano, Sophie Szedlacsek, Evelyn Zelger, Michelle Hämmerle, Brina Zagorc, Alejandro Llanos-Lizcano, Olivia Cheronet, José-Miguel Tejero, Thomas Rattei, Stephan M. Kraemer, and Ron Pinhasi

Subjects
Science
Published
2025
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11. A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils

Author

Victoria Ozberk, Mehfuz Zaman, Ailin Lepletier, Sharareh Eskandari, Jacqualine Kaden, Jamie-Lee Mills, Ainslie Calcutt, Jessica Dooley, Yongbao Huo, Emma L. Langshaw, Glen C. Ulett, Michael R. Batzloff, Michael F. Good, and Manisha Pandey

Subjects
Science
Abstract

Abstract Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide antigen, J8; diphtheria toxoid as a source of T cell help; and the immunostimulatory glycolipid, 3D(6-acyl) PHAD (PHAD), is able to induce long-lived humoral and cellular immunity. Mice genetically deficient in either mucosal antibodies or total antibodies are protected against S. pyogenes respiratory tract infection. Utilizing IL-17-deficient mice or depleting cellular subsets using antibodies, shows that the cellular responses encompassing, CD4+ T cells, IL-17, macrophages and neutrophils have important functions in vaccine-mediated mucosal immunity. Overall, these data demonstrate the utility of a mucosal vaccine platform to deliver multi-pronged protective responses against a highly virulent pathogen.

Published
2023
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12. Author Correction: Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells.

Author

Shender, Victoria O., Anufrieva, Ksenia S., Shnaider, Polina V., Arapidi, Georgij P., Pavlyukov, Marat S., Ivanova, Olga M., Malyants, Irina K., Stepanov, Grigory A., Zhuravlev, Evgenii, Ziganshin, Rustam H., Butenko, Ivan O., Bukato, Olga N., Klimina, Ksenia M., Veselovsky, Vladimir A., Grigorieva, Tatiana V., Malanin, Sergey Y., Aleshikova, Olga I., Slonov, Andrey V., Babaeva, Nataliya A., and Ashrafyan, Lev A.

Subjects
OVARIAN cancer, CANCER cells, INTERNET publishing, SECRETION
Abstract

This correction notice is for an article titled "Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells" published in Nature Communications. The correction addresses an error in the Acknowledgements section, where the State funding project number was incorrect and has been corrected. The authors of the article are listed, and their names are followed by the correction notice. [Extracted from the article]

Published
2024
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13. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

Author

Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F. Shay, Erin E. Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M. Arokiaraj, Viktor M. Plattner, Lillian J. Campos, John K. Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B. Gore, Ed S. Lein, Athena Akrami, Cory Miller, Boaz P. Levi, Annika Keller, Jonathan T. Ting, Andrew S. Fox, Cagla Eroglu, and Viviana Gradinaru

Subjects
Science
Abstract

Abstract Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that transduce brain endothelial cells specifically and efficiently following systemic administration in wild-type mice with diverse genetic backgrounds, and in rats. These AAVs also exhibit superior transduction of the CNS across non-human primates (marmosets and rhesus macaques), and in ex vivo human brain slices, although the endothelial tropism is not conserved across species. The capsid modifications translate from AAV9 to other serotypes such as AAV1 and AAV-DJ, enabling serotype switching for sequential AAV administration in mice. We demonstrate that the endothelial-specific mouse capsids can be used to genetically engineer the blood-brain barrier by transforming the mouse brain vasculature into a functional biofactory. We apply this approach to Hevin knockout mice, where AAV-X1-mediated ectopic expression of the synaptogenic protein Sparcl1/Hevin in brain endothelial cells rescued synaptic deficits.

Published
2023
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14. CD1a promotes systemic manifestations of skin inflammation

Author

Clare S. Hardman, Yi-Ling Chen, Marcin Wegrecki, Soo Weei Ng, Robert Murren, Davinderpreet Mangat, John-Paul Silva, Rebecca Munro, Win Yan Chan, Victoria O’Dowd, Carl Doyle, Prashant Mori, Andy Popplewell, Jamie Rossjohn, Daniel Lightwood, and Graham S. Ogg

Subjects
Science
Abstract

Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation and systemic inflammatory disease, and the generalized symptoms could be alleviated by blocking antibodies developed against CD1a.

Published
2022
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15. SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

Author

Scott B. Biering, Francielle Tramontini Gomes de Sousa, Laurentia V. Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F. Blanc, Trishna S. Patel, Caroline M. Worthington, Dustin R. Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T. N. Lo, Marcus P. Wong, Colin M. Warnes, Daniel R. Sandoval, Thomas Mandel Clausen, Yale A. Santos, Douglas M. Fox, Victoria Ortega, Anders M. Näär, Ralph S. Baric, Sarah A. Stanley, Hector C. Aguilar, Jeffrey D. Esko, Charles Y. Chiu, John E. Pak, P. Robert Beatty, and Eva Harris

Subjects
Science
Abstract

Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction, however, the molecular pathways resulting in endothelial barrier dysfunction and vascular leakage are only sparsely understood. Here, Biering et al. show that SARS-CoV-2 spike protein is sufficient to induce barrier dysfunction and vascular leak. They show a role for integrins, TGF-beta, ECM remodeling enzymes, and glycosaminoglycans in this S-mediated barrier dysfunction.

Published
2022
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16. National identity predicts public health support during a global pandemic

Author

Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda, Yusaku Horiuchi, Toan Luu Duc Huynh, Augustin Ibanez, Mostak Ahamed Imran, Jacob Israelashvili, Katarzyna Jasko, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, André Krouwel, Michael Laakasuo, Claus Lamm, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, John Paul Minda, Panagiotis Mitkidis, Andreas Olsson, Tobias Otterbring, Dominic J. Packer, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Julián C. Riaño-Moreno, Tobias Rothmund, Hernando Santamaría-García, Petra C. Schmid, Drozdstoy Stoyanov, Shruti Tewari, Bojan Todosijević, Manos Tsakiris, Hans H. Tung, Radu G. Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew Vonasch, Meltem Yucel, Yucheng Zhang, Mohcine Abad, Eli Adler, Narin Akrawi, Hamza Alaoui Mdarhri, Hanane Amara, David M. Amodio, Benedict G. Antazo, Matthew Apps, F. Ceren Ay, Mouhamadou Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Maria P. Bernal-Zárate, Michael Bernstein, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E. Booth, Sylvie Borau, Ondrej Buchel, C. Daryl Cameron, Chrissie F. Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo Andres Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Michael A. Daniels, Victoria H. Davis, Pamala N. Dayley, Sylvain Delouvee, Ognjan Denkovski, Guillaume Dezecache, Nathan A. Dhaliwal, Alelie B. Diato, Roberto Di Paolo, Marianna Drosinou, Uwe Dulleck, Jānis Ekmanis, Arhan S. Ertan, Tom W. Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Harry Farmer, Ali Fenwick, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan A. Fugelsang, Jessica Gale, E. Begoña Garcia-Navarro, Prasad Garladinne, Oussama Ghajjou, Theofilos Gkinopoulos, Kurt Gray, Siobhán M. Griffin, Bjarki Gronfeldt, Mert Gümren, Ranju Lama Gurung, Eran Halperin, Elizabeth Harris, Volo Herzon, Matej Hruška, Guanxiong Huang, Matthias F. C. Hudecek, Ozan Isler, Simon Jangard, Frederik J. Jørgensen, Frank Kachanoff, John Kahn, Apsara Katuwal Dangol, Oleksandra Keudel, Lina Koppel, Mika Koverola, Emily Kubin, Anton Kunnari, Yordan Kutiyski, Oscar Laguna, Josh Leota, Eva Lermer, Jonathan Levy, Neil Levy, Chunyun Li, Elizabeth U. Long, Chiara Longoni, Marina Maglić, Darragh McCashin, Alexander L. Metcalf, Igor Mikloušić, Soulaimane El Mimouni, Asako Miura, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Tarik Nesh-Nash, Jonas P. Nitschke, Matthew S. Nurse, Yohsuke Ohtsubo, Victoria Oldemburgo de Mello, Cathal O’Madagain, Michal Onderco, M. Soledad Palacios-Galvez, Jussi Palomäki, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Zoran Pavlović, César Payán-Gómez, Silva Perander, Michael Mark Pitman, Rajib Prasad, Joanna Pyrkosz-Pacyna, Steve Rathje, Ali Raza, Gabriel G. Rêgo, Kasey Rhee, Claire E. Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M. Sampaio, Gaia C. Santi, Natalia Santiago-Tovar, David Savage, Julian A. Scheffer, Philipp Schönegger, David T. Schultner, Enid M. Schutte, Andy Scott, Madhavi Sharma, Pujan Sharma, Ahmed Skali, David Stadelmann, Clara Alexandra Stafford, Dragan Stanojević, Anna Stefaniak, Anni Sternisko, Augustin Stoica, Kristina K. Stoyanova, Brent Strickland, Jukka Sundvall, Jeffrey P. Thomas, Gustav Tinghög, Benno Torgler, Iris J. Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D. Ungson, Mete S. Uysal, Paul A. M. Van Lange, Jan-Willem van Prooijen, Dirk van Rooy, Daniel Västfjäll, Peter Verkoeijen, Joana B. Vieira, Christian von Sikorski, Alexander Cameron Walker, Jennifer Watermeyer, Erik Wetter, Ashley Whillans, Robin Willardt, Michael J. A. Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A. Zwaan, and Paulo S. Boggio

Subjects
Science
Abstract

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Published
2022
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17. Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Author

Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, and David J. Adams

Subjects
Science
Abstract

Systematic screens for synthetic lethal gene pairs represent a powerful approach to define interactions that may be exploited in the clinic. Here, the authors use a dual-guide CRISPR screening approach to screen a curated selection of gene pairs across three cell lines and validate the Fam50a/Fam50b synthetic lethality was in isogenic cell models as well as in an in vivo setting.

Published
2021
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18. Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa

Author

Brian R. Amman, Brian H. Bird, Ibrahim A. Bakarr, James Bangura, Amy J. Schuh, Jonathan Johnny, Tara K. Sealy, Immah Conteh, Alusine H. Koroma, Ibrahim Foday, Emmanuel Amara, Abdulai A. Bangura, Aiah A. Gbakima, Alexandre Tremeau-Bravard, Manjunatha Belaganahalli, Jasjeet Dhanota, Andrew Chow, Victoria Ontiveros, Alexandra Gibson, Joseph Turay, Ketan Patel, James Graziano, Camilla Bangura, Emmanuel S. Kamanda, Augustus Osborne, Emmanuel Saidu, Jonathan Musa, Doris Bangura, Samuel Maxwell Tom Williams, Richard Wadsworth, Mohamed Turay, Lavalie Edwin, Vanessa Mereweather-Thompson, Dickson Kargbo, Fatmata V. Bairoh, Marilyn Kanu, Willie Robert, Victor Lungai, Raoul Emeric Guetiya Wadoum, Moinya Coomber, Osman Kanu, Amara Jambai, Sorie M. Kamara, Celine H. Taboy, Tushar Singh, Jonna A. K. Mazet, Stuart T. Nichol, Tracey Goldstein, Jonathan S. Towner, and Aiah Lebbie

Subjects
Science
Abstract

Egyptian rousette bats (ERBs) are natural reservoirs for Marburg virus (MARV), but these bats have not been linked to the MARV Angola strain that caused the largest and deadliest outbreak on record. Here, Amman et al., in a multi-institutional surveillance effort, identify and isolate Angola-like MARV in ERBs in West Africa.

Published
2020
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19. Author Correction: National identity predicts public health support during a global pandemic

Author

Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda, Yusaku Horiuchi, Toan Luu Duc Huynh, Agustin Ibanez, Mostak Ahamed Imran, Jacob Israelashvili, Katarzyna Jasko, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, André Krouwel, Michael Laakasuo, Claus Lamm, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, John Paul Minda, Panagiotis Mitkidis, Andreas Olsson, Tobias Otterbring, Dominic J. Packer, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Julián C. Riaño-Moreno, Tobias Rothmund, Hernando Santamaría-García, Petra C. Schmid, Drozdstoy Stoyanov, Shruti Tewari, Bojan Todosijević, Manos Tsakiris, Hans H. Tung, Radu G. Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew Vonasch, Meltem Yucel, Yucheng Zhang, Mohcine Abad, Eli Adler, Narin Akrawi, Hamza Alaoui Mdarhri, Hanane Amara, David M. Amodio, Benedict G. Antazo, Matthew Apps, F. Ceren Ay, Mouhamadou Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Maria P. Bernal-Zárate, Michael Bernstein, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E. Booth, Sylvie Borau, Ondrej Buchel, C. Daryl Cameron, Chrissie F. Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo Andres Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Michael A. Daniels, Victoria H. Davis, Pamala N. Dayley, Sylvain Delouvee, Ognjan Denkovski, Guillaume Dezecache, Nathan A. Dhaliwal, Alelie B. Diato, Roberto Di Paolo, Marianna Drosinou, Uwe Dulleck, Jānis Ekmanis, Arhan S. Ertan, Tom W. Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Harry Farmer, Ali Fenwick, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan A. Fugelsang, Jessica Gale, E. Begoña Garcia-Navarro, Prasad Garladinne, Oussama Ghajjou, Theofilos Gkinopoulos, Kurt Gray, Siobhán M. Griffin, Bjarki Gronfeldt, Mert Gümren, Ranju Lama Gurung, Eran Halperin, Elizabeth Harris, Volo Herzon, Matej Hruška, Guanxiong Huang, Matthias F. C. Hudecek, Ozan Isler, Simon Jangard, Frederik J. Jørgensen, Frank Kachanoff, John Kahn, Apsara Katuwal Dangol, Oleksandra Keudel, Lina Koppel, Mika Koverola, Emily Kubin, Anton Kunnari, Yordan Kutiyski, Oscar Laguna, Josh Leota, Eva Lermer, Jonathan Levy, Neil Levy, Chunyun Li, Elizabeth U. Long, Chiara Longoni, Marina Maglić, Darragh McCashin, Alexander L. Metcalf, Igor Mikloušić, Soulaimane El Mimouni, Asako Miura, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Tarik Nesh-Nash, Jonas P. Nitschke, Matthew S. Nurse, Yohsuke Ohtsubo, Victoria Oldemburgo de Mello, Cathal O’Madagain, Michal Onderco, M. Soledad Palacios-Galvez, Jussi Palomäki, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Zoran Pavlović, César Payán-Gómez, Silva Perander, Michael Mark Pitman, Rajib Prasad, Joanna Pyrkosz-Pacyna, Steve Rathje, Ali Raza, Gabriel G. Rêgo, Kasey Rhee, Claire E. Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M. Sampaio, Gaia C. Santi, Natalia Santiago-Tovar, David Savage, Julian A. Scheffer, Philipp Schönegger, David T. Schultner, Enid M. Schutte, Andy Scott, Madhavi Sharma, Pujan Sharma, Ahmed Skali, David Stadelmann, Clara Alexandra Stafford, Dragan Stanojević, Anna Stefaniak, Anni Sternisko, Augustin Stoica, Kristina K. Stoyanova, Brent Strickland, Jukka Sundvall, Jeffrey P. Thomas, Gustav Tinghög, Benno Torgler, Iris J. Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D. Ungson, Mete S. Uysal, Paul A. M. Van Lange, Jan-Willem van Prooijen, Dirk van Rooy, Daniel Västfjäll, Peter Verkoeijen, Joana B. Vieira, Christian von Sikorski, Alexander Cameron Walker, Jennifer Watermeyer, Erik Wetter, Ashley Whillans, Robin Willardt, Michael J. A. Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A. Zwaan, and Paulo S. Boggio

Subjects
Science
Published
2022
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