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Start Over Author "Vera Magg" Journal nature communications
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1. RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

Author

Fabian Poetz, Joshua Corbo, Yevgen Levdansky, Alexander Spiegelhalter, Doris Lindner, Vera Magg, Svetlana Lebedeva, Jörg Schweiggert, Johanna Schott, Eugene Valkov, and Georg Stoecklin

Subjects
Science
Abstract

The CCR4-NOT complex is a key regulator of eukaryotic mRNA deadenylation. Here the authors identified the E3 ubiquitin ligase RNF219 as an acetylation-regulated cofactor of the complex, which inhibits mRNA decay through a direct interaction with NOT9.

Published
2021
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