4 results on '"Van Roon, Arie M."'
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2. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk
- Author
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Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B, Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriëtte, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J.M, Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.
- Published
- 2017
- Full Text
- View/download PDF
3. Genetic loci associated with heart rate variability and their effects on cardiac disease risk
- Author
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Nolte, Ilja M., primary, Munoz, M. Loretto, additional, Tragante, Vinicius, additional, Amare, Azmeraw T., additional, Jansen, Rick, additional, Vaez, Ahmad, additional, von der Heyde, Benedikt, additional, Avery, Christy L., additional, Bis, Joshua C., additional, Dierckx, Bram, additional, van Dongen, Jenny, additional, Gogarten, Stephanie M., additional, Goyette, Philippe, additional, Hernesniemi, Jussi, additional, Huikari, Ville, additional, Hwang, Shih-Jen, additional, Jaju, Deepali, additional, Kerr, Kathleen F., additional, Kluttig, Alexander, additional, Krijthe, Bouwe P., additional, Kumar, Jitender, additional, van der Laan, Sander W., additional, Lyytikäinen, Leo-Pekka, additional, Maihofer, Adam X., additional, Minassian, Arpi, additional, van der Most, Peter J., additional, Müller-Nurasyid, Martina, additional, Nivard, Michel, additional, Salvi, Erika, additional, Stewart, James D., additional, Thayer, Julian F., additional, Verweij, Niek, additional, Wong, Andrew, additional, Zabaneh, Delilah, additional, Zafarmand, Mohammad H., additional, Abdellaoui, Abdel, additional, Albarwani, Sulayma, additional, Albert, Christine, additional, Alonso, Alvaro, additional, Ashar, Foram, additional, Auvinen, Juha, additional, Axelsson, Tomas, additional, Baker, Dewleen G., additional, de Bakker, Paul I. W., additional, Barcella, Matteo, additional, Bayoumi, Riad, additional, Bieringa, Rob J., additional, Boomsma, Dorret, additional, Boucher, Gabrielle, additional, Britton, Annie R., additional, Christophersen, Ingrid, additional, Dietrich, Andrea, additional, Ehret, George B., additional, Ellinor, Patrick T., additional, Eskola, Markku, additional, Felix, Janine F., additional, Floras, John S., additional, Franco, Oscar H., additional, Friberg, Peter, additional, Gademan, Maaike G. J., additional, Geyer, Mark A., additional, Giedraitis, Vilmantas, additional, Hartman, Catharina A., additional, Hemerich, Daiane, additional, Hofman, Albert, additional, Hottenga, Jouke-Jan, additional, Huikuri, Heikki, additional, Hutri-Kähönen, Nina, additional, Jouven, Xavier, additional, Junttila, Juhani, additional, Juonala, Markus, additional, Kiviniemi, Antti M., additional, Kors, Jan A., additional, Kumari, Meena, additional, Kuznetsova, Tatiana, additional, Laurie, Cathy C., additional, Lefrandt, Joop D., additional, Li, Yong, additional, Li, Yun, additional, Liao, Duanping, additional, Limacher, Marian C., additional, Lin, Henry J., additional, Lindgren, Cecilia M., additional, Lubitz, Steven A., additional, Mahajan, Anubha, additional, McKnight, Barbara, additional, zu Schwabedissen, Henriette Meyer, additional, Milaneschi, Yuri, additional, Mononen, Nina, additional, Morris, Andrew P., additional, Nalls, Mike A., additional, Navis, Gerjan, additional, Neijts, Melanie, additional, Nikus, Kjell, additional, North, Kari E., additional, O'Connor, Daniel T., additional, Ormel, Johan, additional, Perz, Siegfried, additional, Peters, Annette, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Risbrough, Victoria B., additional, Sinner, Moritz F., additional, Siscovick, David, additional, Smit, Johannes H., additional, Smith, Nicholas L., additional, Soliman, Elsayed Z., additional, Sotoodehnia, Nona, additional, Staessen, Jan A., additional, Stein, Phyllis K., additional, Stilp, Adrienne M., additional, Stolarz-Skrzypek, Katarzyna, additional, Strauch, Konstantin, additional, Sundström, Johan, additional, Swenne, Cees A., additional, Syvänen, Ann-Christine, additional, Tardif, Jean-Claude, additional, Taylor, Kent D., additional, Teumer, Alexander, additional, Thornton, Timothy A., additional, Tinker, Lesley E., additional, Uitterlinden, André G., additional, van Setten, Jessica, additional, Voss, Andreas, additional, Waldenberger, Melanie, additional, Wilhelmsen, Kirk C., additional, Willemsen, Gonneke, additional, Wong, Quenna, additional, Zhang, Zhu-Ming, additional, Zonderman, Alan B., additional, Cusi, Daniele, additional, Evans, Michele K., additional, Greiser, Halina K., additional, van der Harst, Pim, additional, Hassan, Mohammad, additional, Ingelsson, Erik, additional, Järvelin, Marjo-Riitta, additional, Kääb, Stefan, additional, Kähönen, Mika, additional, Kivimaki, Mika, additional, Kooperberg, Charles, additional, Kuh, Diana, additional, Lehtimäki, Terho, additional, Lind, Lars, additional, Nievergelt, Caroline M., additional, O'Donnell, Chris J., additional, Oldehinkel, Albertine J., additional, Penninx, Brenda, additional, Reiner, Alexander P., additional, Riese, Harriëtte, additional, van Roon, Arie M., additional, Rioux, John D., additional, Rotter, Jerome I., additional, Sofer, Tamar, additional, Stricker, Bruno H., additional, Tiemeier, Henning, additional, Vrijkotte, Tanja G. M., additional, Asselbergs, Folkert W., additional, Brundel, Bianca J. J. M., additional, Heckbert, Susan R., additional, Whitsel, Eric A., additional, den Hoed, Marcel, additional, Snieder, Harold, additional, and de Geus, Eco J. C., additional
- Published
- 2017
- Full Text
- View/download PDF
4. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation.
- Author
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Zhang, Deli, Hu, Xu, Li, Jin, Liu, Jia, Baks-te Bulte, Luciënne, Wiersma, Marit, Malik, Noor-ul-Ann, van Marion, Denise M. S., Tolouee, Marziyeh, Hoogstra-Berends, Femke, Lanters, Eva A. H., van Roon, Arie M., de Vries, Antoine A. F., Pijnappels, Daniël A., de Groot, Natasja M. S., Henning, Robert H., and Brundel, Bianca J. J. M.
- Abstract
Atrial fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to progress in time. AF progression is driven by derailment of protein homeostasis, which ultimately causes contractile dysfunction of the atria. Here we report that tachypacing-induced functional loss of atrial cardiomyocytes is precipitated by excessive poly(ADP)-ribose polymerase 1 (PARP1) activation in response to oxidative DNA damage. PARP1-mediated synthesis of ADP-ribose chains in turn depletes nicotinamide adenine dinucleotide (NAD
+ ), induces further DNA damage and contractile dysfunction. Accordingly, NAD+ replenishment or PARP1 depletion precludes functional loss. Moreover, inhibition of PARP1 protects against tachypacing-induced NAD+ depletion, oxidative stress, DNA damage and contractile dysfunction in atrial cardiomyocytes and Drosophila. Consistently, cardiomyocytes of persistent AF patients show significant DNA damage, which correlates with PARP1 activity. The findings uncover a mechanism by which tachypacing impairs cardiomyocyte function and implicates PARP1 as a possible therapeutic target that may preserve cardiomyocyte function in clinical AF. Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and identify PARP1 inhibition as a potential therapeutic strategy in the treatment of AF. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
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