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Your search keyword '"Sun Hee, Yim"' showing total 3 results
Start Over Author "Sun Hee, Yim" Journal nature communications
3 results on '"Sun Hee, Yim"'

1. Epigenetic aging of the demographically non-aging naked mole-rat

Author

Csaba Kerepesi, Margarita V. Meer, Julia Ablaeva, Vince G. Amoroso, Sang-Goo Lee, Bohan Zhang, Maxim V. Gerashchenko, Alexandre Trapp, Sun Hee Yim, Ake T. Lu, Morgan E. Levine, Andrei Seluanov, Steve Horvath, Thomas J. Park, Vera Gorbunova, and Vadim N. Gladyshev

Subjects
Science
Abstract

The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.

Published
2022
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2. Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

Author

Jung-Hwan Kim, Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J. Chang, Heejung Yang, Tomokazu Nagano, Kristopher W. Krausz, Sun-Hee Yim, and Frank J. Gonzalez

Subjects
Science
Abstract

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function.

Published
2021
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3. Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

Author

Lawrence G. Harshman, Zhen Hu, Alaattin Kaya, Siming Ma, Sun Hee Yim, Byung Cheon Lee, Maxim V. Gerashchenko, Vadim N. Gladyshev, and Gwansu Kim

Subjects
Male, Aging, media_common.quotation_subject, Longevity, Saccharomyces cerevisiae, General Physics and Astronomy, Cell Cycle Proteins, Article, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Methionine, Animals, Drosophila Proteins, Amino Acids, Drosophila, Caloric Restriction, media_common, Genetics, Multidisciplinary, biology, Reproduction, TOR Serine-Threonine Kinases, Receptor Protein-Tyrosine Kinases, Feeding Behavior, General Chemistry, biology.organism_classification, Drosophila melanogaster, chemistry, Female, Dietary Proteins, TSC2, Drosophila Protein, Signal Transduction
Abstract

Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

Published
2014
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