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Your search keyword '"Shan-He Yu"' showing total 2 results
Start Over Author "Shan-He Yu" Journal nature communications
2 results on '"Shan-He Yu"'

1. JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Author

Shan-He Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng-Fei Xu, Wu Zhang, Li Yan, He-Zhou Guo, and Jiang Zhu

Subjects
Science
Abstract

Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.

Published
2018
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2. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish

Author

Ren-Ke Li, Wen-Xue Liang, Sai-Juan Chen, Lei Wang, Ting Xi Liu, Jue-Ling Tan, Liu-Fei Luo, Shan-He Yu, Guoyu Meng, Peng-Fei Xu, Keqin Kathy Li, Zhu Chen, Li-Ting Chen, and Shuo Chen

Subjects
Calmodulin, Regulator, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, Animals, HSP70 Heat-Shock Proteins, Transcriptional expression, Zebrafish, Calcium signaling, Cell Proliferation, Multidisciplinary, biology, Kinase, General Chemistry, Zebrafish Proteins, biology.organism_classification, Fusion protein, Cell biology, Hematopoiesis, Haematopoiesis, Gene Knockdown Techniques, biology.protein, Cancer research, Calcium-Calmodulin-Dependent Protein Kinase Type 4
Abstract

We previously reported a fusion protein NUP98-IQCG in an acute leukaemia, which functions as an aberrant regulator of transcriptional expression, yet the structure and function of IQCG have not been characterized. Here we use zebrafish to investigate the role of iqcg in haematopoietic development, and find that the numbers of haematopoietic stem cells and multilineage-differentiated cells are reduced in iqcg-deficient embryos. Mechanistically, IQCG binds to calmodulin (CaM) and acts as a molecule upstream of CaM-dependent kinase IV (CaMKIV). Crystal structures of complexes between CaM and IQ domain of IQCG reveal dual CaM-binding footprints in this motif, and provide a structural basis for a higher CaM-IQCG affinity when deprived of calcium. The results collectively allow us to understand IQCG-mediated calcium signalling in haematopoiesis, and propose a model in which IQCG stores CaM at low cytoplasmic calcium concentrations, and releases CaM to activate CaMKIV when calcium level rises.

Published
2013

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