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582 results on '"Schulz A"'

1. A giant virus infecting the amoeboflagellate Naegleria

Author

Arthofer, Patrick, Panhölzl, Florian, Delafont, Vincent, Hay, Alban, Reipert, Siegfried, Cyran, Norbert, Wienkoop, Stefanie, Willemsen, Anouk, Sifaoui, Ines, Arberas-Jiménez, Iñigo, Schulz, Frederik, Lorenzo-Morales, Jacob, and Horn, Matthias

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Microbiology, Plant Biology, Medical Microbiology, Infectious Diseases, Emerging Infectious Diseases, Genetics, Biotechnology, Biodefense, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Genome, Viral, Giant Viruses, Naegleria, Naegleria fowleri, Phylogeny, Humans
Abstract

Giant viruses (Nucleocytoviricota) are significant lethality agents of various eukaryotic hosts. Although metagenomics indicates their ubiquitous distribution, available giant virus isolates are restricted to a very small number of protist and algal hosts. Here we report on the first viral isolate that replicates in the amoeboflagellate Naegleria. This genus comprises the notorious human pathogen Naegleria fowleri, the causative agent of the rare but fatal primary amoebic meningoencephalitis. We have elucidated the structure and infection cycle of this giant virus, Catovirus naegleriensis (a.k.a. Naegleriavirus, NiV), and show its unique adaptations to its Naegleria host using fluorescence in situ hybridization, electron microscopy, genomics, and proteomics. Naegleriavirus is only the fourth isolate of the highly diverse subfamily Klosneuvirinae, and like its relatives the NiV genome contains a large number of translation genes, but lacks transfer RNAs (tRNAs). NiV has acquired genes from its Naegleria host, which code for heat shock proteins and apoptosis inhibiting factors, presumably for host interactions. Notably, NiV infection was lethal to all Naegleria species tested, including the human pathogen N. fowleri. This study expands our experimental framework for investigating giant viruses and may help to better understand the basic biology of the human pathogen N. fowleri.

Published
2024

2. Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Author

Wang, Rongling, Gomez Salazar, Mario, Pruñonosa Cervera, Iris, Coutts, Amanda, French, Karen, Pinto, Marlene Magalhaes, Gohlke, Sabrina, García-Martín, Ruben, Blüher, Matthias, Schofield, Christopher J., Kourtzelis, Ioannis, Stimson, Roland H., Bénézech, Cécile, Christian, Mark, Schulz, Tim J., Gudmundsson, Elias F., Jennings, Lori L., Gudnason, Vilmundur G., Chavakis, Triantafyllos, Morton, Nicholas M., Emilsson, Valur, and Michailidou, Zoi

Published
2024
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8. SARS-CoV-2 Mpro responds to oxidation by forming disulfide and NOS/SONOS bonds

Author

Reinke, Patrick Y. A., Schubert, Robin, Oberthür, Dominik, Galchenkova, Marina, Rahmani Mashhour, Aida, Günther, Sebastian, Chretien, Anaïs, Round, Adam, Seychell, Brandon Charles, Norton-Baker, Brenna, Kim, Chan, Schmidt, Christina, Koua, Faisal H. M., Tolstikova, Alexandra, Ewert, Wiebke, Peña Murillo, Gisel Esperanza, Mills, Grant, Kirkwood, Henry, Brognaro, Hévila, Han, Huijong, Koliyadu, Jayanath, Schulz, Joachim, Bielecki, Johan, Lieske, Julia, Maracke, Julia, Knoska, Juraj, Lorenzen, Kristina, Brings, Lea, Sikorski, Marcin, Kloos, Marco, Vakili, Mohammad, Vagovic, Patrik, Middendorf, Philipp, de Wijn, Raphael, Bean, Richard, Letrun, Romain, Han, Seonghyun, Falke, Sven, Geng, Tian, Sato, Tokushi, Srinivasan, Vasundara, Kim, Yoonhee, Yefanov, Oleksandr M., Gelisio, Luca, Beck, Tobias, Doré, Andrew S., Mancuso, Adrian P., Betzel, Christian, Bajt, Saša, Redecke, Lars, Chapman, Henry N., Meents, Alke, Turk, Dušan, Hinrichs, Winfried, and Lane, Thomas J.

Published
2024
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9. A comprehensive genetic map of cytokine responses in Lyme borreliosis

Author

Botey-Bataller, Javier, Vrijmoeth, Hedwig D., Ursinus, Jeanine, Kullberg, Bart-Jan, van den Wijngaard, Cees C., ter Hofstede, Hadewych, Alaswad, Ahmed, Gupta, Manoj K., Roesner, Lennart M., Huehn, Jochen, Werfel, Thomas, Schulz, Thomas F., Xu, Cheng-Jian, Netea, Mihai G., Hovius, Joppe W., Joosten, Leo A. B., and Li, Yang

Published
2024
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13. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Author

Reinisch, Isabel, Michenthaler, Helene, Sulaj, Alba, Moyschewitz, Elisabeth, Krstic, Jelena, Galhuber, Markus, Xu, Ruonan, Riahi, Zina, Wang, Tongtong, Vujic, Nemanja, Amor, Melina, Zenezini Chiozzi, Riccardo, Wabitsch, Martin, Kolb, Dagmar, Georgiadi, Anastasia, Glawitsch, Lisa, Heitzer, Ellen, Schulz, Tim J., Schupp, Michael, Sun, Wenfei, Dong, Hua, Ghosh, Adhideb, Hoffmann, Anne, Kratky, Dagmar, Hinte, Laura C., von Meyenn, Ferdinand, Heck, Albert J. R., Blüher, Matthias, Herzig, Stephan, Wolfrum, Christian, and Prokesch, Andreas

Published
2024
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14. A slow-fast trait continuum at the whole community level in relation to land-use intensification

Author

Neyret, Margot, Le Provost, Gaëtane, Boesing, Andrea Larissa, Schneider, Florian D., Baulechner, Dennis, Bergmann, Joana, de Vries, Franciska T., Fiore-Donno, Anna Maria, Geisen, Stefan, Goldmann, Kezia, Merges, Anna, Saifutdinov, Ruslan A., Simons, Nadja K., Tobias, Joseph A., Zaitsev, Andrey S., Gossner, Martin M., Jung, Kirsten, Kandeler, Ellen, Krauss, Jochen, Penone, Caterina, Schloter, Michael, Schulz, Stefanie, Staab, Michael, Wolters, Volkmar, Apostolakis, Antonios, Birkhofer, Klaus, Boch, Steffen, Boeddinghaus, Runa S., Bolliger, Ralph, Bonkowski, Michael, Buscot, François, Dumack, Kenneth, Fischer, Markus, Gan, Huei Ying, Heinze, Johannes, Hölzel, Norbert, John, Katharina, Klaus, Valentin H., Kleinebecker, Till, Marhan, Sven, Müller, Jörg, Renner, Swen C., Rillig, Matthias C., Schenk, Noëlle V., Schöning, Ingo, Schrumpf, Marion, Seibold, Sebastian, Socher, Stephanie A., Solly, Emily F., Teuscher, Miriam, van Kleunen, Mark, Wubet, Tesfaye, and Manning, Peter

Published
2024
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17. Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Author

Sake, Svenja M., Zhang, Xiaoyu, Rajak, Manoj Kumar, Urbanek-Quaing, Melanie, Carpentier, Arnaud, Gunesch, Antonia P., Grethe, Christina, Matthaei, Alina, Rückert, Jessica, Galloux, Marie, Larcher, Thibaut, Le Goffic, Ronan, Hontonnou, Fortune, Chatterjee, Arnab K., Johnson, Kristen, Morwood, Kaycie, Rox, Katharina, Elgaher, Walid A. M., Huang, Jiabin, Wetzke, Martin, Hansen, Gesine, Fischer, Nicole, Eléouët, Jean-Francois, Rameix-Welti, Marie-Anne, Hirsch, Anna K. H., Herold, Elisabeth, Empting, Martin, Lauber, Chris, Schulz, Thomas F., Krey, Thomas, Haid, Sibylle, and Pietschmann, Thomas

Published
2024
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21. Observation of ultrafast interfacial Meitner-Auger energy transfer in a Van der Waals heterostructure

Author

Dong, Shuo, Beaulieu, Samuel, Selig, Malte, Rosenzweig, Philipp, Christiansen, Dominik, Pincelli, Tommaso, Dendzik, Maciej, Ziegler, Jonas D., Maklar, Julian, Xian, R. Patrick, Neef, Alexander, Mohammed, Avaise, Schulz, Armin, Stadler, Mona, Jetter, Michael, Michler, Peter, Taniguchi, Takashi, Watanabe, Kenji, Takagi, Hidenori, Starke, Ulrich, Chernikov, Alexey, Wolf, Martin, Nakamura, Hiro, Knorr, Andreas, Rettig, Laurenz, and Ernstorfer, Ralph

Published
2023
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22. Infection- or AZD1222 vaccine-mediated immunity reduces SARS-CoV-2 transmission but increases Omicron competitiveness in hamsters

Author

Port, Julia R., Yinda, Claude Kwe, Riopelle, Jade C., Weishampel, Zachary A., Saturday, Taylor A., Avanzato, Victoria A., Schulz, Jonathan E., Holbrook, Myndi G., Barbian, Kent, Perry-Gottschalk, Rose, Haddock, Elaine, Martens, Craig, Shaia, Carl. I., Lambe, Teresa, Gilbert, Sarah C., van Doremalen, Neeltje, and Munster, Vincent J.

Published
2023
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27. DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal

Author

Cattaneo, Paola, Hayes, Michael GB, Baumgarten, Nina, Hecker, Dennis, Peruzzo, Sofia, Aslan, Galip S, Kunderfranco, Paolo, Larcher, Veronica, Zhang, Lunfeng, Contu, Riccardo, Fonseca, Gregory, Spinozzi, Simone, Chen, Ju, Condorelli, Gianluigi, Dimmeler, Stefanie, Schulz, Marcel H, Heinz, Sven, Guimarães-Camboa, Nuno, and Evans, Sylvia M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Pediatric, Cardiovascular, Genetics, Heart Disease, Underpinning research, 1.1 Normal biological development and functioning, Gene Regulatory Networks, Cell Division, Cell Cycle, Myocytes, Cardiac, Heart Ventricles
Abstract

Mechanisms by which specific histone modifications regulate distinct gene networks remain little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and previously considered a general transcriptional activation mark, regulates gene expression during cardiogenesis. Embryonic cardiomyocyte ablation of Dot1l revealed that H3K79me2 does not act as a general transcriptional activator, but rather regulates highly specific transcriptional networks at two critical cardiogenic junctures: embryonic cardiogenesis, where it was particularly important for left ventricle-specific genes, and postnatal cardiomyocyte cell cycle withdrawal, with Dot1L mutants having more mononuclear cardiomyocytes and prolonged cardiomyocyte cell cycle activity. Mechanistic analyses revealed that H3K79me2 in two distinct domains, gene bodies and regulatory elements, synergized to promote expression of genes activated by DOT1L. Surprisingly, H3K79me2 in specific regulatory elements also contributed to silencing genes usually not expressed in cardiomyocytes. These results reveal mechanisms by which DOT1L successively regulates left ventricle specification and cardiomyocyte cell cycle withdrawal.

Published
2022

28. Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers

Author

Holmes, Susannah, Kirkwood, Henry J, Bean, Richard, Giewekemeyer, Klaus, Martin, Andrew V, Hadian-Jazi, Marjan, Wiedorn, Max O, Oberthür, Dominik, Marman, Hugh, Adriano, Luigi, Al-Qudami, Nasser, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Brockhauser, Sandor, Coleman, Mathew A, Cruz-Mazo, Francisco, Danilevski, Cyril, Dörner, Katerina, Gañán-Calvo, Alfonso M, Graceffa, Rita, Fanghor, Hans, Heymann, Michael, Frank, Matthias, Kaukher, Alexander, Kim, Yoonhee, Kobe, Bostjan, Knoška, Juraj, Laurus, Torsten, Letrun, Romain, Maia, Luis, Messerschmidt, Marc, Metz, Markus, Michelat, Thomas, Mills, Grant, Molodtsov, Serguei, Monteiro, Diana CF, Morgan, Andrew J, Münnich, Astrid, Peña Murillo, Gisel E, Previtali, Gianpietro, Round, Adam, Sato, Tokushi, Schubert, Robin, Schulz, Joachim, Shelby, Megan, Seuring, Carolin, Sellberg, Jonas A, Sikorski, Marcin, Silenzi, Alessandro, Stern, Stephan, Sztuk-Dambietz, Jola, Szuba, Janusz, Trebbin, Martin, Vagovic, Patrick, Ve, Thomas, Weinhausen, Britta, Wrona, Krzysztof, Xavier, Paul Lourdu, Xu, Chen, Yefanov, Oleksandr, Nugent, Keith A, Chapman, Henry N, Mancuso, Adrian P, Barty, Anton, Abbey, Brian, and Darmanin, Connie

Subjects
Inorganic Chemistry, Chemical Sciences, Physical Sciences, Biological Sciences, Crystallography, X-Ray, Electrons, Lasers, Radiography, X-Rays
Abstract

The European X-ray Free Electron Laser (XFEL) and Linac Coherent Light Source (LCLS) II are extremely intense sources of X-rays capable of generating Serial Femtosecond Crystallography (SFX) data at megahertz (MHz) repetition rates. Previous work has shown that it is possible to use consecutive X-ray pulses to collect diffraction patterns from individual crystals. Here, we exploit the MHz pulse structure of the European XFEL to obtain two complete datasets from the same lysozyme crystal, first hit and the second hit, before it exits the beam. The two datasets, separated by

Published
2022

29. Lytic archaeal viruses infect abundant primary producers in Earth's crust.

Author

Rahlff, Janina, Turzynski, Victoria, Esser, Sarah P, Monsees, Indra, Bornemann, Till LV, Figueroa-Gonzalez, Perla Abigail, Schulz, Frederik, Woyke, Tanja, Klingl, Andreas, Moraru, Cristina, and Probst, Alexander J

Subjects
Biofilms, Archaeal Viruses, Archaea, RNA, Ribosomal, 16S, Microscopy, Fluorescence, Genomics, Ecosystem, Phylogeny, Lysogeny, Virus Activation, Species Specificity, Genome, Viral, Host-Pathogen Interactions, Metagenome, Metagenomics, Infectious Diseases, Infection
Abstract

The continental subsurface houses a major portion of life's abundance and diversity, yet little is known about viruses infecting microbes that reside there. Here, we use a combination of metagenomics and virus-targeted direct-geneFISH (virusFISH) to show that highly abundant carbon-fixing organisms of the uncultivated genus Candidatus Altiarchaeum are frequent targets of previously unrecognized viruses in the deep subsurface. Analysis of CRISPR spacer matches display resistances of Ca. Altiarchaea against eight predicted viral clades, which show genomic relatedness across continents but little similarity to previously identified viruses. Based on metagenomic information, we tag and image a putatively viral genome rich in protospacers using fluorescence microscopy. VirusFISH reveals a lytic lifestyle of the respective virus and challenges previous predictions that lysogeny prevails as the dominant viral lifestyle in the subsurface. CRISPR development over time and imaging of 18 samples from one subsurface ecosystem suggest a sophisticated interplay of viral diversification and adapting CRISPR-mediated resistances of Ca. Altiarchaeum. We conclude that infections of primary producers with lytic viruses followed by cell lysis potentially jump-start heterotrophic carbon cycling in these subsurface ecosystems.

Published
2021

30. Pangenomics reveals alternative environmental lifestyles among chlamydiae.

Author

Köstlbacher, Stephan, Collingro, Astrid, Halter, Tamara, Schulz, Frederik, Jungbluth, Sean P, and Horn, Matthias

Subjects
Gills, Animals, Fishes, Acanthamoeba, Chlamydia, Pyruvic Acid, Hydrolases, Ecosystem, Phylogeny, Citric Acid Cycle, Genome, Bacterial, Metagenome, Whole Genome Sequencing, Genetics, Human Genome, 2.2 Factors relating to the physical environment
Abstract

Chlamydiae are highly successful strictly intracellular bacteria associated with diverse eukaryotic hosts. Here we analyzed metagenome-assembled genomes of the "Genomes from Earth's Microbiomes" initiative from diverse environmental samples, which almost double the known phylogenetic diversity of the phylum and facilitate a highly resolved view at the chlamydial pangenome. Chlamydiae are defined by a relatively large core genome indicative of an intracellular lifestyle, and a highly dynamic accessory genome of environmental lineages. We observe chlamydial lineages that encode enzymes of the reductive tricarboxylic acid cycle and for light-driven ATP synthesis. We show a widespread potential for anaerobic energy generation through pyruvate fermentation or the arginine deiminase pathway, and we add lineages capable of molecular hydrogen production. Genome-informed analysis of environmental distribution revealed lineage-specific niches and a high abundance of chlamydiae in some habitats. Together, our data provide an extended perspective of the variability of chlamydial biology and the ecology of this phylum of intracellular microbes.

Published
2021

31. A catalog of the diversity and ubiquity of bacterial microcompartments.

Author

Sutter, Markus, Melnicki, Matthew R, Schulz, Frederik, Woyke, Tanja, and Kerfeld, Cheryl A

Subjects
Organelles, Bacteria, Bacterial Proteins, Phylogeny, Cell Compartmentation, Gene Transfer, Horizontal, Genetic Variation, Genetic Loci
Abstract

Bacterial microcompartments (BMCs) are organelles that segregate segments of metabolic pathways which are incompatible with surrounding metabolism. BMCs consist of a selectively permeable shell, composed of three types of structurally conserved proteins, together with sequestered enzymes that vary among functionally distinct BMCs. Genes encoding shell proteins are typically clustered with those for the encapsulated enzymes. Here, we report that the number of identifiable BMC loci has increased twenty-fold since the last comprehensive census of 2014, and the number of distinct BMC types has doubled. The new BMC types expand the range of compartmentalized catalysis and suggest that there is more BMC biochemistry yet to be discovered. Our comprehensive catalog of BMCs provides a framework for their identification, correlation with bacterial niche adaptation, experimental characterization, and development of BMC-based nanoarchitectures for biomedical and bioengineering applications.

Published
2021

32. Author Correction: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria.

Author

Matheus Carnevali, Paula B, Schulz, Frederik, Castelle, Cindy J, Kantor, Rose S, Shih, Patrick M, Sharon, Itai, Santini, Joanne M, Olm, Matthew R, Amano, Yuki, Thomas, Brian C, Anantharaman, Karthik, Burstein, David, Becraft, Eric D, Stepanauskas, Ramunas, Woyke, Tanja, and Banfield, Jillian F

Abstract

The original version of this Article contained errors in Fig. 4. In panel a, the labels 'F420-reducing NiFe hydrogenase (group 3a)' and 'Group 2 NiFe hydrogenase' were misplaced. These errors have been corrected in both the PDF and HTML versions of the Article.

Published
2019

33. Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria.

Author

Matheus Carnevali, Paula B, Schulz, Frederik, Castelle, Cindy J, Kantor, Rose S, Shih, Patrick M, Sharon, Itai, Santini, Joanne M, Olm, Matthew R, Amano, Yuki, Thomas, Brian C, Anantharaman, Karthik, Burstein, David, Becraft, Eric D, Stepanauskas, Ramunas, Woyke, Tanja, and Banfield, Jillian F

Subjects
Cyanobacteria, Oxygen, Hydrogen, Hydrogenase, Nitrogenase, Bacterial Proteins, Sequence Analysis, DNA, Phylogeny, Species Specificity, Aerobiosis, Anaerobiosis, Fermentation, Oxidation-Reduction, Genome, Bacterial, Sequence Analysis, DNA, Genome, Bacterial, MD Multidisciplinary
Abstract

The evolution of aerobic respiration was likely linked to the origins of oxygenic Cyanobacteria. Close phylogenetic neighbors to Cyanobacteria, such as Margulisbacteria (RBX-1 and ZB3), Saganbacteria (WOR-1), Melainabacteria and Sericytochromatia, may constrain the metabolic platform in which aerobic respiration arose. Here, we analyze genomic sequences and predict that sediment-associated Margulisbacteria have a fermentation-based metabolism featuring a variety of hydrogenases, a streamlined nitrogenase, and electron bifurcating complexes involved in cycling of reducing equivalents. The genomes of ocean-associated Margulisbacteria encode an electron transport chain that may support aerobic growth. Some Saganbacteria genomes encode various hydrogenases, and others may be able to use O2 under certain conditions via a putative novel type of heme copper O2 reductase. Similarly, Melainabacteria have diverse energy metabolisms and are capable of fermentation and aerobic or anaerobic respiration. The ancestor of all these groups may have been an anaerobe in which fermentation and H2 metabolism were central metabolic features. The ability to use O2 as a terminal electron acceptor must have been subsequently acquired by these lineages.

Published
2019

34. Hidden diversity of soil giant viruses.

Author

Schulz, Frederik, Alteio, Lauren, Goudeau, Danielle, Ryan, Elizabeth M, Yu, Feiqiao B, Malmstrom, Rex R, Blanchard, Jeffrey, and Woyke, Tanja

Subjects
Capsid Proteins, Soil, Ecosystem, Phylogeny, Gene Expression, Genome, Viral, Metagenome, Metagenomics, Mimiviridae, High-Throughput Nucleotide Sequencing, Genome Size, Giant Viruses, Genome, Viral, Genetics, 2.2 Factors relating to physical environment, Infection, MD Multidisciplinary
Abstract

Known giant virus diversity is currently skewed towards viruses isolated from aquatic environments and cultivated in the laboratory. Here, we employ cultivation-independent metagenomics and mini-metagenomics on soils from the Harvard Forest, leading to the discovery of 16 novel giant viruses, chiefly recovered by mini-metagenomics. The candidate viruses greatly expand phylogenetic diversity of known giant viruses and either represented novel lineages or are affiliated with klosneuviruses, Cafeteria roenbergensis virus or tupanviruses. One assembled genome with a size of 2.4 Mb represents the largest currently known viral genome in the Mimiviridae, and others encode up to 80% orphan genes. In addition, we find more than 240 major capsid proteins encoded on unbinned metagenome fragments, further indicating that giant viruses are underexplored in soil ecosystems. The fact that most of these novel viruses evaded detection in bulk metagenomes suggests that mini-metagenomics could be a valuable approach to unearth viral giants.

Published
2018

37. High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance

Author

Cortés-López, Mariela, Schulz, Laura, Enculescu, Mihaela, Paret, Claudia, Spiekermann, Bea, Quesnel-Vallières, Mathieu, Torres-Diz, Manuel, Unic, Sebastian, Busch, Anke, Orekhova, Anna, Kuban, Monika, Mesitov, Mikhail, Mulorz, Miriam M., Shraim, Rawan, Kielisch, Fridolin, Faber, Jörg, Barash, Yoseph, Thomas-Tikhonenko, Andrei, Zarnack, Kathi, Legewie, Stefan, and König, Julian

Published
2022
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38. Therapeutic targeting of ATR in alveolar rhabdomyosarcoma

Author

Dorado García, Heathcliff, Pusch, Fabian, Bei, Yi, von Stebut, Jennifer, Ibáñez, Glorymar, Guillan, Kristina, Imami, Koshi, Gürgen, Dennis, Rolff, Jana, Helmsauer, Konstantin, Meyer-Liesener, Stephanie, Timme, Natalie, Bardinet, Victor, Chamorro González, Rocío, MacArthur, Ian C., Chen, Celine Y., Schulz, Joachim, Wengner, Antje M., Furth, Christian, Lala, Birgit, Eggert, Angelika, Seifert, Georg, Hundsoerfer, Patrick, Kirchner, Marieluise, Mertins, Philipp, Selbach, Matthias, Lissat, Andrej, Dubois, Frank, Horst, David, Schulte, Johannes H., Spuler, Simone, You, Daoqi, Dela Cruz, Filemon, Kung, Andrew L., Haase, Kerstin, DiVirgilio, Michela, Scheer, Monika, Ortiz, Michael V., and Henssen, Anton G.

Published
2022
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43. Tertiary lymphoid structures critical for prognosis in endometrial cancer patients

Author

Horeweg, Nanda, Workel, Hagma H., Loiero, Dominik, Church, David N., Vermij, Lisa, Léon-Castillo, Alicia, Krog, Ricki T., de Boer, Stephanie M., Nout, Remi A., Powell, Melanie E., Mileshkin, Linda R., MacKay, Helen, Leary, Alexandra, Singh, Naveena, Jürgenliemk-Schulz, Ina M., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Koelzer, Viktor H., Nijman, Hans W., Bosse, Tjalling, and de Bruyn, Marco

Published
2022
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44. Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

Author

Paul, Tanja, Ledderose, Stephan, Bartsch, Harald, Sun, Na, Soliman, Sarah, Märkl, Bruno, Ruf, Viktoria, Herms, Jochen, Stern, Marcel, Keppler, Oliver T., Delbridge, Claire, Müller, Susanna, Piontek, Guido, Kimoto, Yuki Schneider, Schreiber, Franziska, Williams, Tracy Ann, Neumann, Jens, Knösel, Thomas, Schulz, Heiko, Spallek, Ria, Graw, Matthias, Kirchner, Thomas, Walch, Axel, and Rudelius, Martina

Published
2022
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45. How Carvedilol activates β2-adrenoceptors

Author

Benkel, Tobias, Zimmermann, Mirjam, Zeiner, Julian, Bravo, Sergi, Merten, Nicole, Lim, Victor Jun Yu, Matthees, Edda Sofie Fabienne, Drube, Julia, Miess-Tanneberg, Elke, Malan, Daniela, Szpakowska, Martyna, Monteleone, Stefania, Grimes, Jak, Koszegi, Zsombor, Lanoiselée, Yann, O’Brien, Shannon, Pavlaki, Nikoleta, Dobberstein, Nadine, Inoue, Asuka, Nikolaev, Viacheslav, Calebiro, Davide, Chevigné, Andy, Sasse, Philipp, Schulz, Stefan, Hoffmann, Carsten, Kolb, Peter, Waldhoer, Maria, Simon, Katharina, Gomeza, Jesus, and Kostenis, Evi

Published
2022
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46. ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Author

van Doremalen, Neeltje, Schulz, Jonathan E., Adney, Danielle R., Saturday, Taylor A., Fischer, Robert J., Yinda, Claude Kwe, Thakur, Nazia, Newman, Joseph, Ulaszewska, Marta, Belij-Rammerstorfer, Sandra, Saturday, Greg, Spencer, Alexandra J., Bailey, Dalan, Russell, Colin A., Gilbert, Sarah C., Lambe, Teresa, and Munster, Vincent J.

Published
2022
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47. Author Correction: Vascular surveillance by haptotactic blood platelets in inflammation and infection

Author

Nicolai, Leo, Schiefelbein, Karin, Lipsky, Silvia, Leunig, Alexander, Hoffknecht, Marie, Pekayvaz, Kami, Raude, Ben, Marx, Charlotte, Ehrlich, Andreas, Pircher, Joachim, Zhang, Zhe, Saleh, Inas, Marel, Anna-Kristina, Löf, Achim, Petzold, Tobias, Lorenz, Michael, Stark, Konstantin, Pick, Robert, Rosenberger, Gerhild, Weckbach, Ludwig, Uhl, Bernd, Xia, Sheng, Reichel, Christoph Andreas, Walzog, Barbara, Schulz, Christian, Zheden, Vanessa, Bender, Markus, Li, Rong, Massberg, Steffen, and Gaertner, Florian

Published
2022
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50. HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

Author

Leisegang, Matthias S., Bains, Jasleen Kaur, Seredinski, Sandra, Oo, James A., Krause, Nina M., Kuo, Chao-Chung, Günther, Stefan, Sentürk Cetin, Nevcin, Warwick, Timothy, Cao, Can, Boos, Frederike, Izquierdo Ponce, Judit, Haydar, Shaza, Bednarz, Rebecca, Valasarajan, Chanil, Fuhrmann, Dominik C., Preussner, Jens, Looso, Mario, Pullamsetti, Soni S., Schulz, Marcel H., Jonker, Hendrik R. A., Richter, Christian, Rezende, Flávia, Gilsbach, Ralf, Pflüger-Müller, Beatrice, Wittig, Ilka, Grummt, Ingrid, Ribarska, Teodora, Costa, Ivan G., Schwalbe, Harald, and Brandes, Ralf P.

Published
2022
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