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Your search keyword '"Saliba, Antoine-Emmanuel"' showing total 13 results
Start Over Author "Saliba, Antoine-Emmanuel" Journal nature communications
13 results on '"Saliba, Antoine-Emmanuel"'

1. Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis

Author

Kumar, Naveen, Prakash, Pon Ganish, Wentland, Christian, Kurian, Shilpa Mary, Jethva, Gaurav, Brinkmann, Volker, Mollenkopf, Hans-Joachim, Krammer, Tobias, Toussaint, Christophe, Saliba, Antoine-Emmanuel, Biebl, Matthias, Jürgensen, Christian, Wiedenmann, Bertram, Meyer, Thomas F., Gurumurthy, Rajendra Kumar, and Chumduri, Cindrilla

Published
2024
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4. Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease

Author

McFleder, Rhonda L., Makhotkina, Anastasiia, Groh, Janos, Keber, Ursula, Imdahl, Fabian, Peña Mosca, Josefina, Peteranderl, Alina, Wu, Jingjing, Tabuchi, Sawako, Hoffmann, Jan, Karl, Ann-Kathrin, Pagenstecher, Axel, Vogel, Jörg, Beilhack, Andreas, Koprich, James B., Brotchie, Jonathan M., Saliba, Antoine-Emmanuel, Volkmann, Jens, and Ip, Chi Wang

Published
2023
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6. Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Author

Zhang, Yujiao, Vandestienne, Marie, Lavillegrand, Jean-Rémi, Joffre, Jeremie, Santos-Zas, Icia, Lavelle, Aonghus, Zhong, Xiaodan, Le Goff, Wilfried, Guérin, Maryse, Al-Rifai, Rida, Laurans, Ludivine, Bruneval, Patrick, Guérin, Coralie, Diedisheim, Marc, Migaud, Melanie, Puel, Anne, Lanternier, Fanny, Casanova, Jean-Laurent, Cochain, Clément, Zernecke, Alma, Saliba, Antoine-Emmanuel, Mokry, Michal, Silvestre, Jean-Sebastien, Tedgui, Alain, Mallat, Ziad, Taleb, Soraya, Lenoir, Olivia, Vindis, Cécile, Camus, Stéphane M., Sokol, Harry, and Ait-Oufella, Hafid

Published
2023
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8. Author Correction: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Author

Al-Rifai, Rida, Vandestienne, Marie, Lavillegrand, Jean-Rémi, Mirault, Tristan, Cornebise, Julie, Poisson, Johanne, Laurans, Ludivine, Esposito, Bruno, James, Chloé, Mansier, Olivier, Hirsch, Pierre, Favale, Fabrizia, Braik, Rayan, Knosp, Camille, Vilar, Jose, Rizzo, Giuseppe, Zernecke, Alma, Saliba, Antoine-Emmanuel, Tedgui, Alain, Lacroix, Maxime, Arrive, Lionel, Mallat, Ziad, Taleb, Soraya, Diedisheim, Marc, Cochain, Clément, Rautou, Pierre-Emmanuel, and Ait-Oufella, Hafid

Published
2022
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9. JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Author

Al-Rifai, Rida, Vandestienne, Marie, Lavillegrand, Jean-Rémi, Mirault, Tristan, Cornebise, Julie, Poisson, Johanne, Laurans, Ludivine, Esposito, Bruno, James, Chloé, Mansier, Olivier, Hirsch, Pierre, Favale, Fabrizia, Braik, Rayan, Knosp, Camille, Vilar, Jose, Rizzo, Giuseppe, Zernecke, Alma, Saliba, Antoine-Emmanuel, Tedgui, Alain, Lacroix, Maxime, Arrive, Lionel, Mallat, Ziad, Taleb, Soraya, Diedisheim, Marc, Cochain, Clément, Rautou, Pierre-Emmanuel, and Ait-Oufella, Hafid

Published
2022
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10. Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets

Author

Pezoldt, Joern, Wiechers, Carolin, Zou, Mangge, Litovchenko, Maria, Biocanin, Marjan, Beckstette, Michael, Sitnik, Katarzyna, Palatella, Martina, van Mierlo, Guido, Chen, Wanze, Gardeux, Vincent, Floess, Stefan, Ebel, Maria, Russeil, Julie, Arampatzi, Panagiota, Vafardanejad, Ehsan, Saliba, Antoine-Emmanuel, Deplancke, Bart, and Huehn, Jochen

Published
2022
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11. Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson's disease.

Author

McFleder, Rhonda L., Makhotkina, Anastasiia, Groh, Janos, Keber, Ursula, Imdahl, Fabian, Peña Mosca, Josefina, Peteranderl, Alina, Wu, Jingjing, Tabuchi, Sawako, Hoffmann, Jan, Karl, Ann-Kathrin, Pagenstecher, Axel, Vogel, Jörg, Beilhack, Andreas, Koprich, James B., Brotchie, Jonathan M., Saliba, Antoine-Emmanuel, Volkmann, Jens, and Ip, Chi Wang

Subjects
PARKINSON'S disease, LABORATORY mice, ANIMAL disease models, ALPHA-synuclein, ENCEPHALITIS, MICROGLIA
Abstract

Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson's disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c+ cells. Using single-cell RNA sequencing, we demonstrate that ileal CD11c+ cells are microglia-like and the same subtype of cells is activated in the brain and ileum of PD mice. Moreover, by utilizing mice expressing the photo-convertible protein, Dendra2, we show that CD11c+ cells traffic from the brain to the ileum. Together these data provide a mechanism of αSyn trafficking between the brain and gut. Despite being implicated in several neurological diseases, the gut-brain axis remains poorly understood. Here the authors describe a mechanism of communication between the brain and the gut in a Parkinson's disease mouse model mediated by CD11c+ macrophages. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

Author

Pezoldt, Joern, Pasztoi, Maria, Zou, Mangge, Wiechers, Carolin, Beckstette, Michael, Thierry, Guilhem R., Vafadarnejad, Ehsan, Floess, Stefan, Arampatzi, Panagiota, Buettner, Manuela, Schweer, Janina, Fleissner, Diana, Vital, Marius, Pieper, Dietmar H., Basic, Marijana, Dersch, Petra, Strowig, Till, Hornef, Mathias, Bleich, André, Bode, Ulrike, Pabst, Oliver, Bajénoff, Marc, Saliba, Antoine-Emmanuel, and Huehn, Jochen

Published
2018
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13. JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Author

Rida Al-Rifai, Marie Vandestienne, Jean-Rémi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloé James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clément Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella, Al-Rifai, Rida [0000-0002-6976-0011], Vilar, Jose [0000-0002-9136-7726], Saliba, Antoine-Emmanuel [0000-0001-8539-2784], Tedgui, Alain [0000-0002-7229-4875], Taleb, Soraya [0000-0002-6650-619X], Diedisheim, Marc [0000-0002-0418-1107], Ait-Oufella, Hafid [0000-0002-2955-0183], and Apollo - University of Cambridge Repository

Subjects
Mice, Aortic Dissection, Multidisciplinary, Phenotype, Macrophages, Mutation, General Physics and Astronomy, Animals, General Chemistry, General Biochemistry, Genetics and Molecular Biology, Aortic Aneurysm
Abstract

JAK2V617F mutation is associated with an increased risk for athero-thrombotic cardiovascular disease, but its role in aortic disease development and complications remains unknown. In a cohort of patients with myeloproliferative neoplasm, JAK2V617F mutation was identified as an independent risk factor for dilation of both the ascending and descending thoracic aorta. Using single-cell RNA-seq, complementary genetically-modified mouse models, as well as pharmacological approaches, we found that JAK2V617F mutation was associated with a pathogenic pro-inflammatory phenotype of perivascular tissue-resident macrophages, which promoted deleterious aortic wall remodeling at early stages, and dissecting aneurysm through the recruitment of circulating monocytes at later stages. Finally, genetic manipulation of tissue-resident macrophages, or treatment with a Jak2 inhibitor, ruxolitinib, mitigated aortic wall inflammation and reduced aortic dilation and rupture. Overall, JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.

Published
2022

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