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Abstract Ocean waves excite continuous globally observable seismic signals. We use data from 52 globally distributed seismographs to analyze the vertical component primary microseism wavefield at 14–20 s period between the late 1980s and August 2022. This signal is principally composed of Rayleigh waves generated by ocean wave seafloor tractions at less than several hundred meters depth, and is thus a proxy for near-coastal swell activity. Here we show that increasing seismic amplitudes at 3σ significance occur at 41 (79%) and negative trends occur at 3σ significance at eight (15%) sites. The greatest absolute increase occurs for the Antarctic Peninsula with respective acceleration amplitude and energy trends ( ± 3σ) of 0.037 ± 0.008 nm s−2y−1 (0.36 ± 0.08% y−1) and 4.16 ± 1.07 nm2 s−2y−1 (0.58 ± 0.15% y−1), where percentage trends are relative to historical medians. The inferred global mean near-coastal ocean wave energy increase rate is 0.27 ± 0.03% y−1 for all data and is 0.35 ± 0.04% y−1 since 1 January 2000. Strongly correlated seismic amplitude station histories occur to beyond 50∘ of separation and show regional-to-global associations with El Niño and La Niña events.

Selecting economic policies to achieve sustainable development is challenging due to the many sectors involved and the trade-offs implied. Artificial intelligence combined with economy-wide computer simulations can help.

Here we present a new approach to diffraction imaging of amyloid fibrils, combining a free-standing graphene support and single nanofocused X-ray pulses of femtosecond duration from an X-ray free-electron laser. Due to the very low background scattering from the graphene support and mutual alignment of filaments, diffraction from tobacco mosaic virus (TMV) filaments and amyloid protofibrils is obtained to 2.7 Å and 2.4 Å resolution in single diffraction patterns, respectively. Some TMV diffraction patterns exhibit asymmetry that indicates the presence of a limited number of axial rotations in the XFEL focus. Signal-to-noise levels from individual diffraction patterns are enhanced using computational alignment and merging, giving patterns that are superior to those obtainable from synchrotron radiation sources. We anticipate that our approach will be a starting point for further investigations into unsolved structures of filaments and other weakly scattering objects.

Urease is a nickel enzyme responsible for catalyzing the conversion of urea into ammonia and carbon dioxide. Here the authors report a high resolution cryo-EM structure of urease from the bacterial pathogen Yersinia enterocolitica, providing a detailed visualization of the urease bimetal active site and a basis for drug development.

The clinical application of T cell bispecific antibodies (TCBs) is often limited by the lack of tumour-specific antigens. In this study, the authors present a strategy to increase TCB tumour-selectivity by adding an anti-CD3 moiety that can be specifically activated by tumor specific proteases in the tumor microenvironment.

The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.

A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19845-z.