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Your search keyword '"Raju Tomer"' showing total 2 results
Start Over Author "Raju Tomer" Journal nature communications
2 results on '"Raju Tomer"'

1. An in vitro model of neuronal ensembles

Author

M. Angeles Rabadan, Estanislao Daniel De La Cruz, Sneha B. Rao, Yannan Chen, Cheng Gong, Gregg Crabtree, Bin Xu, Sander Markx, Joseph A. Gogos, Rafael Yuste, and Raju Tomer

Subjects
Science
Abstract

Advances in 3D neuronal cultures have allowed unprecedented access to the mechanisms underlying brain diseases. This work describes the novel Modular Neuronal Network (MoNNet) system, which enables more complex studies of cortical neuronal ensemble dynamics.

Published
2022
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2. Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Author

Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin Strauss, Frank Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Brundu, Karlla W. Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, Jonathan A. Javitch, Bin Xu, and Sander Markx

Subjects
Science
Abstract

Mutations in CNTNAP2 have been associated with a syndromic form of Autism Spectrum Disorder. Here the authors show that forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of ASD with a homozygous truncating mutation in CNTNAP2 displayed an increase in volume and total cell number, which is driven by abnormal cellular proliferation and neurogenesis.

Published
2021
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