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1. A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension

Author

Anna Popkova, Orrin J. Stone, Lin Chen, Xiang Qin, Chang Liu, Jiaying Liu, Karine Belguise, Denise J. Montell, Klaus M. Hahn, Matteo Rauzi, and Xiaobo Wang

Subjects
Science
Abstract

During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.

Published
2020
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2. A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension

Author

Xiang Qin, Matteo Rauzi, Chang Liu, Anna Popkova, Denise J. Montell, Klaus M. Hahn, Orrin J. Stone, Xiaobo Wang, Jiaying Liu, Karine Belguise, Lin Chen, Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération (LBCMCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Third Military Medical University [Chongqing, Chine], University of Electronic Science and Technology of China [Chengdu] (UESTC), Huazhong University of Science and Technology [Wuhan] (HUST), University of California [Santa Barbara] (UC Santa Barbara), University of California (UC), This work was supported by the Institut National de la Santé et de la Recherche Médicale [ATIP-Avenir program (2012–2016)], Région Midi-Pyrénées Excellence program (2013–2016) and Scientifiques de la Fondation ARC (grant number PJA 20171206526, PJA20191209714), all to XW, the French government through the UCAJEDI Investments in the Future project managed by the National Research Agency (ANR-15-IDEX-01), the 'Investments for the Future' LABEX SIGNALIFE (ANR-11-LABX-0028-01), the Tramplin ERC program from the National Research Agency (ANR-16-TERC-0018-01), the ATIP-Avenir program from the CNRS and the Human Frontier Science Program (CDA00027/2017-C), all to M.R., the National Institutes of Health (GM-R35GM122596) to K.M.H., and the National Institutes of Health (grant GM46425) to D.J.M., ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), ANR-16-TERC-0018,SEPASEDTM,Etude sur les Propriétés Emergeantes à l'Echelle de l'Embryon Dirigeantes la Morphogène des Tissus(2016), Bodescot, Myriam, Centres d'excellences - Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie - - SIGNALIFE2011 - ANR-11-LABX-0028 - LABX - VALID, Etude sur les Propriétés Emergeantes à l'Echelle de l'Embryon Dirigeantes la Morphogène des Tissus - - SEPASEDTM2016 - ANR-16-TERC-0018 - TERC - VALID, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), University of Electronic Science and Technology of China (UESTC), University of California [Santa Barbara] (UCSB), University of California, Institute for Computational Earth System Science [Santa Barbara] (ICESS), University of California-University of California, European Molecular Biology Laboratory [Heidelberg] (EMBL), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI (2016)

Subjects
[SDV]Life Sciences [q-bio], General Physics and Astronomy, CDC42, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Epithelium, 0302 clinical medicine, Oogenesis, Cell polarity, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Morphogenesis, Drosophila Proteins, Small GTPase, Pseudopodia, Cytoskeleton, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Glutathione Transferase, 0303 health sciences, Multidisciplinary, Chemistry, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Cell Polarity, Actomyosin, Mechanosensitive channels, Drosophila, Female, RNA Interference, Filopodia, Science, 1.1 Normal biological development and functioning, Green Fluorescent Proteins, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Underpinning research, GTP-Binding Proteins, Cell Adhesion, Animals, Actin, 030304 developmental biology, Myosin Type II, General Chemistry, Actins, Optogenetics, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Biophysics, Anisotropy, lcsh:Q, Generic health relevance, 030217 neurology & neurosurgery
Abstract

Actomyosin supracellular networks emerge during development and tissue repair. These cytoskeletal structures are able to generate large scale forces that can extensively remodel epithelia driving tissue buckling, closure and extension. How supracellular networks emerge, are controlled and mechanically work still remain elusive. During Drosophila oogenesis, the egg chamber elongates along the anterior-posterior axis. Here we show that a dorsal-ventral polarized supracellular F-actin network, running around the egg chamber on the basal side of follicle cells, emerges from polarized intercellular filopodia that radiate from basal stress fibers and extend penetrating neighboring cell cortexes. Filopodia can be mechanosensitive and function as cell-cell anchoring sites. The small GTPase Cdc42 governs the formation and distribution of intercellular filopodia and stress fibers in follicle cells. Finally, our study shows that a Cdc42-dependent supracellular cytoskeletal network provides a scaffold integrating local oscillatory actomyosin contractions at the tissue scale to drive global polarized forces and tissue elongation., During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.

Published
2017
Full Text
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