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Start Over Author "Nigel D. L. Savage" Journal nature communications
1 results on '"Nigel D. L. Savage"'

1. Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

Author

Cornelis J. Korbee, Matthias T. Heemskerk, Dragi Kocev, Elisabeth van Strijen, Omid Rabiee, Kees L. M. C. Franken, Louis Wilson, Nigel D. L. Savage, Sašo Džeroski, Mariëlle C. Haks, and Tom H. M. Ottenhoff

Subjects
Science
Abstract

Multidrug resistance necessitates novel approaches to treating bacterial infections. Here, the authors apply their high-throughput screening and in silico prediction approaches to show that host receptor tyrosine kinases are good targets for host-directed therapies against intracellular bacteria.

Published
2018
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