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Your search keyword '"Morad Roudbaraki"' showing total 2 results
Start Over Author "Morad Roudbaraki" Journal nature communications
2 results on '"Morad Roudbaraki"'

1. TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

Author

Valerio Farfariello, Dmitri V. Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loïc Lemonnier, and Natalia Prevarskaya

Subjects
Science
Abstract

Mitochondrial Ca2+ homeostasis is reported to influence cellular senescence. Here the authors show that TRPC3 limits senescence by inhibiting IP3R-mediated Ca2+ release and ER mitochondria Ca2+ transfer and that the downregulation of TRPC3 in stromal cells affects SASP production and tumour progression.

Published
2022
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2. TRPC3 shapes the ER-mitochondria Ca

Author

Valerio, Farfariello, Dmitri V, Gordienko, Lina, Mesilmany, Yasmine, Touil, Emmanuelle, Germain, Ingrid, Fliniaux, Emilie, Desruelles, Dimitra, Gkika, Morad, Roudbaraki, George, Shapovalov, Lucile, Noyer, Mathilde, Lebas, Laurent, Allart, Nathalie, Zienthal-Gelus, Oksana, Iamshanova, Franck, Bonardi, Martin, Figeac, William, Laine, Jerome, Kluza, Philippe, Marchetti, Bruno, Quesnel, Daniel, Metzger, David, Bernard, Jan B, Parys, Loïc, Lemonnier, and Natalia, Prevarskaya

Subjects
Carcinogenesis, Primary Cell Culture, Endoplasmic Reticulum, Oxidative Phosphorylation, Mitochondria, HEK293 Cells, Cell Line, Tumor, Neoplasms, Humans, Inositol 1,4,5-Trisphosphate Receptors, Calcium, Cellular Senescence, Cell Proliferation, TRPC Cation Channels
Abstract

Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence drivers, the underlying mechanisms remain elusive. We report the mechanism altering mitochondrial function and OXPHOS in stress-induced senescent fibroblasts. We demonstrate that TRPC3 protein, acting as a controller of mitochondrial Ca

Published
2019

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