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Start Over Author "Kiani P" Journal nature communications
17 results on '"Kiani P"'

1. High-throughput fluorescence lifetime imaging flow cytometry

Author

Kanno, Hiroshi, Hiramatsu, Kotaro, Mikami, Hideharu, Nakayashiki, Atsushi, Yamashita, Shota, Nagai, Arata, Okabe, Kohki, Li, Fan, Yin, Fei, Tominaga, Keita, Bicer, Omer Faruk, Noma, Ryohei, Kiani, Bahareh, Efa, Olga, Büscher, Martin, Wazawa, Tetsuichi, Sonoshita, Masahiro, Shintaku, Hirofumi, Nagai, Takeharu, Braun, Sigurd, Houston, Jessica P., Rashad, Sherif, Niizuma, Kuniyasu, and Goda, Keisuke

Published
2024
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4. Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

Author

McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, and Blurton-Jones, Mathew

Published
2023
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5. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.

Author

McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H, Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G Aleph, Thompson, Leslie M, Steffan, Joan S, Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, and Blurton-Jones, Mathew

Subjects
Brain, Microglia, Cell Line, Animals, Mice, Inbred BALB C, Mice, Transgenic, Mice, Knockout, Mice, Alzheimer Disease, Disease Models, Animal, Genetic Predisposition to Disease, Membrane Glycoproteins, Receptors, CXCR4, Receptors, Immunologic, Cell Death, Chemotaxis, Phagocytosis, Gene Expression Regulation, Female, Male, Chemokine CXCL12, Gene Knockout Techniques, Amyloid beta-Peptides, Plaque, Amyloid, Transcriptome, Inbred BALB C, Transgenic, Knockout, Disease Models, Animal, Receptors, CXCR4, Immunologic, Plaque, Amyloid
Abstract

The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To examine this question, we profile microglia differentiated from isogenic, CRISPR-modified TREM2-knockout induced pluripotent stem cell (iPSC) lines. By combining transcriptomic and functional analyses with a chimeric AD mouse model, we find that TREM2 deletion reduces microglial survival, impairs phagocytosis of key substrates including APOE, and inhibits SDF-1α/CXCR4-mediated chemotaxis, culminating in an impaired response to beta-amyloid plaques in vivo. Single-cell sequencing of xenotransplanted human microglia further highlights a loss of disease-associated microglial (DAM) responses in human TREM2 knockout microglia that we validate by flow cytometry and immunohistochemistry. Taken together, these studies reveal both conserved and novel aspects of human TREM2 biology that likely play critical roles in the development and progression of AD.

Published
2020

6. An artificial spiking afferent nerve based on Mott memristors for neurorobotics.

Author

Zhang, Xumeng, Zhuo, Ye, Luo, Qing, Wu, Zuheng, Midya, Rivu, Wang, Zhongrui, Song, Wenhao, Wang, Rui, Upadhyay, Navnidhi K, Fang, Yilin, Kiani, Fatemeh, Rao, Mingyi, Yang, Yang, Xia, Qiangfei, Liu, Qi, Liu, Ming, and Yang, J Joshua

Subjects
Afferent Pathways, Mechanoreceptors, Oxides, Niobium, Titanium, Equipment Design, Robotics, Neural Prostheses, Neural Networks, Computer, Neural Networks, Computer
Abstract

Neuromorphic computing based on spikes offers great potential in highly efficient computing paradigms. Recently, several hardware implementations of spiking neural networks based on traditional complementary metal-oxide semiconductor technology or memristors have been developed. However, an interface (called an afferent nerve in biology) with the environment, which converts the analog signal from sensors into spikes in spiking neural networks, is yet to be demonstrated. Here we propose and experimentally demonstrate an artificial spiking afferent nerve based on highly reliable NbOx Mott memristors for the first time. The spiking frequency of the afferent nerve is proportional to the stimuli intensity before encountering noxiously high stimuli, and then starts to reduce the spiking frequency at an inflection point. Using this afferent nerve, we further build a power-free spiking mechanoreceptor system with a passive piezoelectric device as the tactile sensor. The experimental results indicate that our afferent nerve is promising for constructing self-aware neurorobotics in the future.

Published
2020

9. A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Author

Crouchet, Emilie, Bandiera, Simonetta, Fujiwara, Naoto, Li, Shen, El Saghire, Hussein, Fernández-Vaquero, Mirian, Riedl, Tobias, Sun, Xiaochen, Hirschfield, Hadassa, Jühling, Frank, Zhu, Shijia, Roehlen, Natascha, Ponsolles, Clara, Heydmann, Laura, Saviano, Antonio, Qian, Tongqi, Venkatesh, Anu, Lupberger, Joachim, Verrier, Eloi R., Sojoodi, Mozhdeh, Oudot, Marine A., Duong, François H. T., Masia, Ricard, Wei, Lan, Thumann, Christine, Durand, Sarah C., González-Motos, Victor, Heide, Danijela, Hetzer, Jenny, Nakagawa, Shigeki, Ono, Atsushi, Song, Won-Min, Higashi, Takaaki, Sanchez, Roberto, Kim, Rosa S., Bian, C. Billie, Kiani, Karun, Croonenborghs, Tom, Subramanian, Aravind, Chung, Raymond T., Straub, Beate K., Schuppan, Detlef, Ankavay, Maliki, Cocquerel, Laurence, Schaeffer, Evelyne, Goossens, Nicolas, Koh, Anna P., Mahajan, Milind, Nair, Venugopalan D., Gunasekaran, Ganesh, Schwartz, Myron E., Bardeesy, Nabeel, Shalek, Alex K., Rozenblatt-Rosen, Orit, Regev, Aviv, Felli, Emanuele, Pessaux, Patrick, Tanabe, Kenneth K., Heikenwälder, Mathias, Schuster, Catherine, Pochet, Nathalie, Zeisel, Mirjam B., Fuchs, Bryan C., Hoshida, Yujin, and Baumert, Thomas F.

Published
2021
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17. Publisher Correction: High-throughput fluorescence lifetime imaging flow cytometry

Author

Kanno, Hiroshi, Hiramatsu, Kotaro, Mikami, Hideharu, Nakayashiki, Atsushi, Yamashita, Shota, Nagai, Arata, Okabe, Kohki, Li, Fan, Yin, Fei, Tominaga, Keita, Bicer, Omer Faruk, Noma, Ryohei, Kiani, Bahareh, Efa, Olga, Büscher, Martin, Wazawa, Tetsuichi, Sonoshita, Masahiro, Shintaku, Hirofumi, Nagai, Takeharu, Braun, Sigurd, Houston, Jessica P., Rashad, Sherif, Niizuma, Kuniyasu, and Goda, Keisuke

Published
2025
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