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Start Over Author "Katelyn M. Green" Journal nature communications
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1. RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Author

Katelyn M. Green, M. Rebecca Glineburg, Michael G. Kearse, Brittany N. Flores, Alexander E. Linsalata, Stephen J. Fedak, Aaron C. Goldstrohm, Sami J. Barmada, and Peter K. Todd

Subjects
Science
Abstract

A nucleotide repeat expansion in C9orf72 is a common genetic cause of neurodegenerative disorders. Here, the authors provide insight into the molecular mechanism by which this repeat undergoes Repeat-Associated Non-AUG (RAN) translation, implicating the integrated stress response and eIF2α phosphorylation.

Published
2017
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