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3 results on '"Joe N. Frost"'

1. Metabolic requirements of NK cells during the acute response against retroviral infection

Author

Elisabeth Littwitz-Salomon, Diana Moreira, Joe N. Frost, Chloe Choi, Kevin T. Liou, David K. Ahern, Simon O’Shaughnessy, Bernd Wagner, Christine A. Biron, Hal Drakesmith, Ulf Dittmer, and David K. Finlay

Subjects
Science
Abstract

Metabolic alterations control the fate and function of immune cells in response to infections, but the function of NK cell metabolism in the context of acute viral infections is unclear. Here the authors show that acute NK cell responses to Friend retrovirus involve increased glycolysis and mitochondrial metabolism and require amino acid transport as well as iron sufficiency.

Published
2021
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2. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Author

Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, and Hal Drakesmith

Subjects
Science
Abstract

Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

Published
2017
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3. Metabolic requirements of NK cells during the acute response against retroviral infection

Author

Chloe Choi, Ulf Dittmer, David K. Finlay, Kevin T. Liou, David K. Ahern, Diana Moreira, Bernd Wagner, Hal Drakesmith, Joe N. Frost, Elisabeth Littwitz-Salomon, Simon O’Shaughnessy, and Christine A. Biron

Subjects
Science, Cell, Medizin, General Physics and Astronomy, HIV Infections, Biology, Mitochondrion, General Biochemistry, Genetics and Molecular Biology, Large Neutral Amino Acid-Transporter 1, Mice, Retrovirus, Bone Marrow, medicine, Animals, Amino acid transporter, Mice, Knockout, Multidisciplinary, SARS-CoV-2, Innate lymphoid cell, COVID-19, HIV, General Chemistry, Iron deficiency, Viral Load, medicine.disease, biology.organism_classification, Mitochondria, Killer Cells, Natural, Mice, Inbred C57BL, medicine.anatomical_structure, Retroviridae, Immunology, Cytokines, Signal transduction, Viral load, Retroviridae Infections
Abstract

Natural killer (NK) cells are important early responders against viral infections. Changes in metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell dysfunction in obesity and cancer. However, very little is known about the metabolic requirements of NK cells during acute retroviral infection and their importance for antiviral immunity. Here, using the Friend retrovirus mouse model, we show that following infection NK cells increase nutrient uptake, including amino acids and iron, and reprogram their metabolic machinery by increasing glycolysis and mitochondrial metabolism. Specific deletion of the amino acid transporter Slc7a5 has only discrete effects on NK cells, but iron deficiency profoundly impaires NK cell antiviral functions, leading to increased viral loads. Our study thus shows the requirement of nutrients and metabolism for the antiviral activity of NK cells, and has important implications for viral infections associated with altered iron levels such as HIV and SARS-CoV-2.

Published
2021

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