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Start Over Author "Jacklyn Liu" Journal nature communications
3 results on '"Jacklyn Liu"'

1. DNA methylation-based classification of sinonasal tumors

Author

Philipp Jurmeister, Stefanie Glöß, Renée Roller, Maximilian Leitheiser, Simone Schmid, Liliana H. Mochmann, Emma Payá Capilla, Rebecca Fritz, Carsten Dittmayer, Corinna Friedrich, Anne Thieme, Philipp Keyl, Armin Jarosch, Simon Schallenberg, Hendrik Bläker, Inga Hoffmann, Claudia Vollbrecht, Annika Lehmann, Michael Hummel, Daniel Heim, Mohamed Haji, Patrick Harter, Benjamin Englert, Stephan Frank, Jürgen Hench, Werner Paulus, Martin Hasselblatt, Wolfgang Hartmann, Hildegard Dohmen, Ursula Keber, Paul Jank, Carsten Denkert, Christine Stadelmann, Felix Bremmer, Annika Richter, Annika Wefers, Julika Ribbat-Idel, Sven Perner, Christian Idel, Lorenzo Chiariotti, Rosa Della Monica, Alfredo Marinelli, Ulrich Schüller, Michael Bockmayr, Jacklyn Liu, Valerie J. Lund, Martin Forster, Matt Lechner, Sara L. Lorenzo-Guerra, Mario Hermsen, Pascal D. Johann, Abbas Agaimy, Philipp Seegerer, Arend Koch, Frank Heppner, Stefan M. Pfister, David T. W. Jones, Martin Sill, Andreas von Deimling, Matija Snuderl, Klaus-Robert Müller, Erna Forgó, Brooke E. Howitt, Philipp Mertins, Frederick Klauschen, and David Capper

Subjects
Science
Abstract

Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiation state and clinical outcome.

Published
2022
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2. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

Author

Matt Lechner, Volker H. Schartinger, Christopher D. Steele, Wen Long Nei, Marc Lucas Ooft, Liesa-Marie Schreiber, Christodoulos P. Pipinikas, Grace Tin-Yun Chung, Yuk Yu Chan, Feng Wu, Ka-Fai To, Chi Man Tsang, Wayne Pearce, Daniele Morelli, Martin Philpott, Liam Masterson, Reshma Nibhani, Graham Wells, Christopher G. Bell, Julia Koller, Susanne Delecluse, Yim Ling Yip, Jacklyn Liu, Cillian T. Forde, Martin D. Forster, Amrita Jay, József Dudás, Annika Krapp, Simon Wan, Christian Uprimny, Susanne Sprung, Johannes Haybaeck, Tim R. Fenton, Kerry Chester, Christina Thirlwell, Gary Royle, Teresa Marafioti, Rajeev Gupta, Sagung Rai Indrasari, Camelia Herdini, Mohd Afiq Mohd Slim, I. Indrawati, Liam Sutton, Renske Fles, Bing Tan, Joe Yeong, Amit Jain, Shuting Han, Haitao Wang, Kelvin S. H. Loke, Wan He, Ruilian Xu, Hongtao Jin, Zhiqiang Cheng, David Howard, Peter H. Hwang, Quynh-Thu Le, Joshua K. Tay, Robert B. West, Sai Wah Tsao, Tim Meyer, Herbert Riechelmann, Udo Oppermann, Henri-Jacques Delecluse, Stefan M. Willems, Melvin L. K. Chua, Pierre Busson, Kwok Wai Lo, Guido Wollmann, Nischalan Pillay, Bart Vanhaesebroeck, and Valerie J. Lund

Subjects
Science
Abstract

Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role in the diagnosis, imaging, targeted therapies and prognosis of NPC.

Published
2021
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3. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

Author

David Howard, Haitao Wang, Kelvin Siu Hoong Loke, Marc L Ooft, Martin Forster, Teresa Marafioti, Bing Tan, Yim Ling Yip, Christopher D. Steele, Liesa Marie Schreiber, I. Indrawati, Sai Wah Tsao, Jozsef Dudas, Ruilian Xu, Martin Philpott, Wayne Pearce, Quynh-Thu Le, Susanne Delecluse, Shuting Han, Feng Wu, Herbert Riechelmann, Nischalan Pillay, Cillian T. Forde, Guido Wollmann, Zhiqiang Cheng, Johannes Haybaeck, Rajeev Gupta, Jacklyn Liu, Volker Hans Schartinger, Joshua K. Tay, Wen Long Nei, Simon Wan, Mohd Afiq Mohd Slim, Wan He, Kerry A. Chester, Daniele Morelli, Joe Yeong, Susanne Sprung, Udo Oppermann, Matt Lechner, Stefan M. Willems, Amit Jain, Christopher G. Bell, Kwok Wai Lo, Yuk Yu Chan, Gary Royle, Henri Jacques Delecluse, Renske Fles, Graham Wells, Christian Uprimny, Liam Sutton, Chi Man Tsang, Philippe Busson, Christodoulos P. Pipinikas, Amrita Jay, Tim Meyer, Peter H. Hwang, Hongtao Jin, Julia Koller, Tim R. Fenton, Valerie J. Lund, Ka Fai To, Annika Krapp, Camelia Herdini, Liam Masterson, Christina Thirlwell, Melvin L.K. Chua, Grace Tin-Yun Chung, Robert B. West, Bart Vanhaesebroeck, Reshma Nibhani, Sagung Rai Indrasari, Institut Gustave Roussy (IGR), RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Keel Neus Oorheelkunde (9), KNO, Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Subjects
0301 basic medicine, Male, Epstein-Barr Virus Infections, Herpesvirus 4, Human, medicine.medical_treatment, [SDV]Life Sciences [q-bio], General Physics and Astronomy, Octreotide, Targeted therapy, Mice, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, Somatostatin receptor 2, Molecular Targeted Therapy, Receptors, Somatostatin, Head and neck cancer, Cancer, Multidisciplinary, Nasopharyngeal Carcinoma, NF-kappa B, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Host-Pathogen Interactions, Female, Signal Transduction, CARCINOMA, Science, Mice, Nude, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antineoplastic Agents, General Biochemistry, Genetics and Molecular Biology, Virus, Article, Viral Matrix Proteins, 03 medical and health sciences, Cell Line, Tumor, otorhinolaryngologic diseases, medicine, Animals, Humans, Survival rate, Epstein–Barr virus infection, Survival analysis, business.industry, association, Nasopharyngeal Neoplasms, General Chemistry, medicine.disease, Survival Analysis, Xenograft Model Antitumor Assays, stomatognathic diseases, 030104 developmental biology, Cancer research, neuroendocrine tumors, Neoplasm Recurrence, Local, business
Abstract

Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. We show that SSTR2 expression is induced by the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-κB pathway. Using cell-based and preclinical rodent models, we demonstrate the therapeutic potential of SSTR2 targeting using a cytotoxic drug conjugate, PEN-221, which is found to be superior to FDA-approved SSTR2-binding cytostatic agents. Furthermore, we reveal significant correlation of SSTR expression with increased rates of survival and report in vivo uptake of the SSTR2-binding 68Ga-DOTA-peptide radioconjugate in PET-CT scanning in a clinical trial of NPC patients (NCT03670342). These findings reveal a key role in EBV-associated NPC for SSTR2 in infection, imaging, targeted therapy and survival., Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role in the diagnosis, imaging, targeted therapies and prognosis of NPC.

Published
2020
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