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Your search keyword '"Gregory Lefebvre"' showing total 2 results
Start Over Author "Gregory Lefebvre" Journal nature communications
2 results on '"Gregory Lefebvre"'

1. Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Author

Armand Valsesia, Qiao-Ping Wang, Nele Gheldof, Jérôme Carayol, Hélène Ruffieux, Teleri Clark, Victoria Shenton, Lisa J. Oyston, Gregory Lefebvre, Sylviane Metairon, Christian Chabert, Ondine Walter, Polina Mironova, Paulina Lau, Patrick Descombes, Nathalie Viguerie, Dominique Langin, Mary-Ellen Harper, Arne Astrup, Wim H. Saris, Robert Dent, Greg G. Neely, and Jörg Hager

Subjects
Science
Abstract

Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in flies.

Published
2019
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2. Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Author

Jérôme Carayol, Christian Chabert, Alessandro Di Cara, Claudia Armenise, Gregory Lefebvre, Dominique Langin, Nathalie Viguerie, Sylviane Metairon, Wim H. M. Saris, Arne Astrup, Patrick Descombes, Armand Valsesia, and Jörg Hager

Subjects
Science
Abstract

Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.

Published
2017
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