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Your search keyword '"George R, Ambalathingal"' showing total 2 results
Start Over Author "George R, Ambalathingal" Journal nature communications
2 results on '"George R, Ambalathingal"'

1. Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3

Author

Srividhya Swaminathan, Katie E. Lineburg, Archana Panikkar, Jyothy Raju, Lawton D. Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J. Dewar-Oldis, Peter J. Barnard, George R. Ambalathingal, Michelle A. Neller, Kirsty R. Short, Stephanie Gras, Rajiv Khanna, and Corey Smith

Subjects
Science
Abstract

The T cell response to SARS-CoV-2 is important in protection from infection. Here the authors show by concentrating on a specific HLA haplotype that mutations in SARS-CoV-2 as new variants emerge can affect T cell recognition and reduce T cell responses to the virus.

Published
2022
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2. Ablation of CD8

Author

Srividhya, Swaminathan, Katie E, Lineburg, Archana, Panikkar, Jyothy, Raju, Lawton D, Murdolo, Christopher, Szeto, Pauline, Crooks, Laetitia, Le Texier, Sweera, Rehan, Michael J, Dewar-Oldis, Peter J, Barnard, George R, Ambalathingal, Michelle A, Neller, Kirsty R, Short, Stephanie, Gras, Rajiv, Khanna, and Corey, Smith

Subjects
Immunodominant Epitopes, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Humans, COVID-19, CD8-Positive T-Lymphocytes, Antibodies, Viral, Antibodies, Neutralizing
Abstract

The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8

Published
2022

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