Search

Your search keyword '"Gennaro Ilardi"' showing total 3 results
Start Over Author "Gennaro Ilardi" Journal nature communications
3 results on '"Gennaro Ilardi"'

1. Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

Author

Caterina Miro, Emery Di Cicco, Raffaele Ambrosio, Giuseppina Mancino, Daniela Di Girolamo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Maria Angela De Stefano, Cristina Luongo, Dario Antonini, Feliciano Visconte, Silvia Varricchio, Gennaro Ilardi, Luigi Del Vecchio, Stefania Staibano, Anita Boelen, Cedric Blanpain, Caterina Missero, Domenico Salvatore, and Monica Dentice

Subjects
Science
Abstract

The invasion of epithelial tumours often depends on the epithelial-mesenchymal transition. Here, the authors report that intracellular activation of thyroid hormone by the D2 deiodinase enzyme promotes invasion and progression of squamous cell carcinoma by transcriptionally up-regulating ZEB-1.

Published
2019
Full Text
View/download PDF

2. Author Correction: Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

Author

Caterina Miro, Emery Di Cicco, Raffaele Ambrosio, Giuseppina Mancino, Daniela Di Girolamo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Maria Angela De Stefano, Cristina Luongo, Dario Antonini, Feliciano Visconte, Silvia Varricchio, Gennaro Ilardi, Luigi Del Vecchio, Stefania Staibano, Anita Boelen, Cedric Blanpain, Caterina Missero, Domenico Salvatore, and Monica Dentice

Subjects
Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020
Full Text
View/download PDF

3. Author Correction: Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

Author

Silvia Varricchio, Monica Dentice, Daniela Di Girolamo, Stefania Staibano, Domenico Salvatore, Caterina Missero, Feliciano Visconte, Annarita Nappi, Emery Di Cicco, Dario Antonini, Serena Sagliocchi, Anita Boelen, Cristina Luongo, Cédric Blanpain, Luigi Del Vecchio, Gennaro Ilardi, Annunziata Gaetana Cicatiello, Raffaele Ambrosio, Caterina Miro, Giuseppina Mancino, and Maria Angela De Stefano

Subjects
Adult, Oncology, Cell biology, Thyroid Hormones, medicine.medical_specialty, Epithelial-Mesenchymal Transition, Skin Neoplasms, Molecular biology, Science, General Physics and Astronomy, Mice, Transgenic, Iodide Peroxidase, General Biochemistry, Genetics and Molecular Biology, Endocrinology, Antigens, CD, Cell Movement, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, lcsh:Science, Author Correction, Cancer, Aged, Aged, 80 and over, Multidisciplinary, Cadherin, business.industry, Published Erratum, Thyroid, Zinc Finger E-box-Binding Homeobox 1, General Chemistry, Middle Aged, Cadherins, medicine.anatomical_structure, Carcinoma, Squamous Cell, lcsh:Q, business, Biomedical sciences, Hormone
Abstract

Epithelial tumor progression often involves epithelial-mesenchymal transition (EMT). We report that increased intracellular levels of thyroid hormone (TH) promote the EMT and malignant evolution of squamous cell carcinoma (SCC) cells. TH induces the EMT by transcriptionally up-regulating ZEB-1, mesenchymal genes and metalloproteases and suppresses E-cadherin expression. Accordingly, in human SCC, elevated D2 (the T3-producing enzyme) correlates with tumor grade and is associated with an increased risk of postsurgical relapse and shorter disease-free survival. These data provide the first in vivo demonstration that TH and its activating enzyme, D2, play an effective role not only in the EMT but also in the entire neoplastic cascade starting from tumor formation up to metastatic transformation, and supports the concept that TH is an EMT promoter. Our studies indicate that tumor progression relies on precise T3 availability, suggesting that pharmacological inactivation of D2 and TH signaling may suppress the metastatic proclivity of SCC.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results