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Start Over Author "Fleming, Adam" Journal nature communications
3 results on '"Fleming, Adam"'

1. Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Author

Kameda-Smith, Michelle M., Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G., Adile, Ashley A., Bakhshinyan, David, Brown, Kevin, Gwynne, William D., Subapanditha, Minomi, Miletic, Petar, Picard, Daniel, Burns, Ian, Moffat, Jason, Paruch, Kamil, Fleming, Adam, Hope, Kristin, Provias, John P., Remke, Marc, Lu, Yu, Reya, Tannishtha, Venugopal, Chitra, Reimand, Jüri, Wechsler-Reya, Robert J., Yeo, Gene W., and Singh, Sheila K.

Published
2023
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2. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Author

Kameda-Smith, Michelle M, Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G, Adile, Ashley A, Bakhshinyan, David, Brown, Kevin, Gwynne, William D, Subapanditha, Minomi, Miletic, Petar, Picard, Daniel, Burns, Ian, Moffat, Jason, Paruch, Kamil, Fleming, Adam, Hope, Kristin, Provias, John P, Remke, Marc, Lu, Yu, Reya, Tannishtha, Venugopal, Chitra, Reimand, Jüri, Wechsler-Reya, Robert J, Yeo, Gene W, and Singh, Sheila K

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Neurosciences, Genetics, Rare Diseases, Pediatric Cancer, Pediatric, Cancer, Brain Cancer, Brain Disorders, Human Genome, Biotechnology, Aetiology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Animals, Mice, Humans, Proteomics, Medulloblastoma, RNA-Binding Proteins, Brain Neoplasms, Cerebellar Neoplasms, Nerve Tissue Proteins
Abstract

Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in G3 MB, however, therapeutic targeting of the MYC pathway remains limited and alternative therapies for G3 MB are urgently needed. Here we show that the RNA-binding protein, Musashi-1 (MSI1) is an essential mediator of G3 MB in both MYC-overexpressing mouse models and patient-derived xenografts. MSI1 inhibition abrogates tumor initiation and significantly prolongs survival in both models. We identify binding targets of MSI1 in normal neural and G3 MB stem cells and then cross referenced these data with unbiased large-scale screens at the transcriptomic, translatomic and proteomic levels to systematically dissect its functional role. Comparative integrative multi-omic analyses of these large datasets reveal cancer-selective MSI1-bound targets sharing multiple MYC associated pathways, providing a valuable resource for context-specific therapeutic targeting of G3 MB.

Published
2022

3. Wnt activation as a therapeutic strategy in medulloblastoma

Author

Manoranjan, Branavan, Venugopal, Chitra, Bakhshinyan, David, Adile, Ashley A., Richards, Laura, Kameda-Smith, Michelle M., Whitley, Owen, Dvorkin-Gheva, Anna, Subapanditha, Minomi, Savage, Neil, Tatari, Nazanin, McKenna, Dillon, Bassey-Archibong, Blessing, Winegarden, Neil, Hallett, Robin, Provias, John P., Yarascavitch, Blake, Ajani, Olufemi, Fleming, Adam, Bader, Gary D., Pugh, Trevor J., Doble, Bradley W., and Singh, Sheila K.

Published
2020
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