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A drug used at the maximum tolerated dose can exert a strong selective pressure on cancer cells leading to resistance. In this study, the authors demonstrate the efficacy of using low dose of multiple drugs for preventing and treating resistance to EGFR tyrosine kinase inhibitors in NSCLC cells.

Decision-making balances the benefits of additional information with the cost of time, but it is unclear whether humans adjust this balance within individual decisions. Here, authors show that we do make such adjustments to suit contextual demands and suggest that these are driven by modulation of neural gain.

Nature Communications 7: Article number: 13526 (2016); Published: 24 November 2016; Updated: 18 January 2017 In Fig. 4c of this Article, the colour bars were inadvertently changed from graded to solid during the production process. The correct version of Fig. 4c appears below as Fig. 1.