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Your search keyword '"Davies, Robert W"' showing total 3 results
Start Over Author "Davies, Robert W" Journal nature communications
3 results on '"Davies, Robert W"'

1. Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation

Author

Bernkopf, Marie, Abdullah, Ummi B., Bush, Stephen J., Wood, Katherine A., Ghaffari, Sahar, Giannoulatou, Eleni, Koelling, Nils, Maher, Geoffrey J., Thibaut, Loïc M., Williams, Jonathan, Blair, Edward M., Kelly, Fiona Blanco, Bloss, Angela, Burkitt-Wright, Emma, Canham, Natalie, Deng, Alexander T., Dixit, Abhijit, Eason, Jacqueline, Elmslie, Frances, Gardham, Alice, Hay, Eleanor, Holder, Muriel, Homfray, Tessa, Hurst, Jane A., Johnson, Diana, Jones, Wendy D., Kini, Usha, Kivuva, Emma, Kumar, Ajith, Lees, Melissa M., Leitch, Harry G., Morton, Jenny E. V., Németh, Andrea H., Ramachandrappa, Shwetha, Saunders, Katherine, Shears, Deborah J., Side, Lucy, Splitt, Miranda, Stewart, Alison, Stewart, Helen, Suri, Mohnish, Clouston, Penny, Davies, Robert W., Wilkie, Andrew O. M., and Goriely, Anne

Published
2023
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2. A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

Author

Li, Ran, Bitoun, Emmanuelle, Altemose, Nicolas, Davies, Robert W, Davies, Benjamin, and Myers, Simon R

Subjects
Human Genome, Biotechnology, Genetics, Contraception/Reproduction, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Alleles, Animals, Cell Cycle Proteins, Chromosomes, Crossing Over, Genetic, DNA Breaks, Double-Stranded, DNA Damage, DNA Mismatch Repair, Female, Gene Conversion, Genetic Variation, Histone-Lysine N-Methyltransferase, Histones, Homologous Recombination, Humans, Hybridization, Genetic, Male, Mice, Mice, Inbred C57BL, Models, Genetic, Phosphate-Binding Proteins, Polymorphism, Single Nucleotide, Recombinational DNA Repair
Abstract

During meiotic recombination, homologue-templated repair of programmed DNA double-strand breaks (DSBs) produces relatively few crossovers and many difficult-to-detect non-crossovers. By intercrossing two diverged mouse subspecies over five generations and deep-sequencing 119 offspring, we detect thousands of crossover and non-crossover events genome-wide with unprecedented power and spatial resolution. We find that both crossovers and non-crossovers are strongly depleted at DSB hotspots where the DSB-positioning protein PRDM9 fails to bind to the unbroken homologous chromosome, revealing that PRDM9 also functions to promote homologue-templated repair. Our results show that complex non-crossovers are much rarer in mice than humans, consistent with complex events arising from accumulated non-programmed DNA damage. Unexpectedly, we also find that GC-biased gene conversion is restricted to non-crossover tracts containing only one mismatch. These results demonstrate that local genetic diversity profoundly alters meiotic repair pathway decisions via at least two distinct mechanisms, impacting genome evolution and Prdm9-related hybrid infertility.

Published
2019

3. Sequencing of human genomes with nanopore technology

Author

Bowden, Rory, Davies, Robert W., Heger, Andreas, Pagnamenta, Alistair T., de Cesare, Mariateresa, Oikkonen, Laura E., Parkes, Duncan, Freeman, Colin, Dhalla, Fatima, Patel, Smita Y., Popitsch, Niko, Ip, Camilla L. C., Roberts, Hannah E., Salatino, Silvia, Lockstone, Helen, Lunter, Gerton, Taylor, Jenny C., Buck, David, Simpson, Michael A., and Donnelly, Peter

Published
2019
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