8 results on '"Daniel J. Jackson"'
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2. FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
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Tarunveer S. Ahluwalia, Anders U. Eliasen, Astrid Sevelsted, Casper-Emil T. Pedersen, Jakob Stokholm, Bo Chawes, Jette Bork-Jensen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Amitabh Sharma, Scott T. Weiss, Michael D. Evans, Daniel J. Jackson, Andreanne Morin, Karen A. Krogfelt, Susanne Schjørring, Preben B. Mortensen, David M. Hougaard, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Ole Mors, Merete Nordentoft, Anders D. Børglum, Thomas Werge, Esben Agerbo, James E. Gern, Robert F. Lemanske, Carole Ober, Anders G. Pedersen, Hans Bisgaard, and Klaus Bønnelykke
- Subjects
Science - Abstract
Genetic variants discovered through genome-wide association studies for asthma together account for a small portion of the heritability. Here, the authors identify a possible epistatic relationship between coding variants in FUT2 and ABO, especially pronounced in severe and early onset asthma.
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- 2020
- Full Text
- View/download PDF
3. Whole genome analysis of a schistosomiasis-transmitting freshwater snail
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Coen M. Adema, LaDeana W. Hillier, Catherine S. Jones, Eric S. Loker, Matty Knight, Patrick Minx, Guilherme Oliveira, Nithya Raghavan, Andrew Shedlock, Laurence Rodrigues do Amaral, Halime D. Arican-Goktas, Juliana G. Assis, Elio Hideo Baba, Olga L. Baron, Christopher J. Bayne, Utibe Bickham-Wright, Kyle K. Biggar, Michael Blouin, Bryony C. Bonning, Chris Botka, Joanna M. Bridger, Katherine M. Buckley, Sarah K. Buddenborg, Roberta Lima Caldeira, Julia Carleton, Omar S. Carvalho, Maria G. Castillo, Iain W. Chalmers, Mikkel Christensens, Sandra Clifton, Celine Cosseau, Christine Coustau, Richard M. Cripps, Yesid Cuesta-Astroz, Scott F. Cummins, Leon di Stefano, Nathalie Dinguirard, David Duval, Scott Emrich, Cédric Feschotte, Rene Feyereisen, Peter FitzGerald, Catrina Fronick, Lucinda Fulton, Richard Galinier, Sandra G. Gava, Michael Geusz, Kathrin K. Geyer, Gloria I. Giraldo-Calderón, Matheus de Souza Gomes, Michelle A. Gordy, Benjamin Gourbal, Christoph Grunau, Patrick C. Hanington, Karl F. Hoffmann, Daniel Hughes, Judith Humphries, Daniel J. Jackson, Liana K. Jannotti-Passos, Wander de Jesus Jeremias, Susan Jobling, Bishoy Kamel, Aurélie Kapusta, Satwant Kaur, Joris M. Koene, Andrea B. Kohn, Dan Lawson, Scott P Lawton, Di Liang, Yanin Limpanont, Sijun Liu, Anne E. Lockyer, TyAnna L. Lovato, Fernanda Ludolf, Vince Magrini, Donald P. McManus, Monica Medina, Milind Misra, Guillaume Mitta, Gerald M. Mkoji, Michael J. Montague, Cesar Montelongo, Leonid L. Moroz, Monica C. Munoz-Torres, Umar Niazi, Leslie R. Noble, Francislon S. Oliveira, Fabiano S. Pais, Anthony T. Papenfuss, Rob Peace, Janeth J. Pena, Emmanuel A. Pila, Titouan Quelais, Brian J. Raney, Jonathan P. Rast, David Rollinson, Izinara C. Rosse, Bronwyn Rotgans, Edwin J. Routledge, Kathryn M. Ryan, Larissa L. S. Scholte, Kenneth B. Storey, Martin Swain, Jacob A. Tennessen, Chad Tomlinson, Damian L. Trujillo, Emanuela V. Volpi, Anthony J. Walker, Tianfang Wang, Ittiprasert Wannaporn, Wesley C. Warren, Xiao-Jun Wu, Timothy P. Yoshino, Mohammed Yusuf, Si-Ming Zhang, Min Zhao, and Richard K. Wilson
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Science - Abstract
Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.
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- 2017
- Full Text
- View/download PDF
4. Correction: Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail
- Author
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Coen M. Adema, LaDeana W. Hillier, Catherine S. Jones, Eric S. Loker, Matty Knight, Patrick Minx, Guilherme Oliveira, Nithya Raghavan, Andrew Shedlock, Laurence Rodrigues do Amaral, Halime D. Arican-Goktas, Juliana G. Assis, Elio Hideo Baba, Olga L. Baron, Christopher J. Bayne, Utibe Bickham-Wright, Kyle K. Biggar, Michael Blouin, Bryony C. Bonning, Chris Botka, Joanna M. Bridger, Katherine M. Buckley, Sarah K. Buddenborg, Roberta Lima Caldeira, Julia Carleton, Omar S. Carvalho, Maria G. Castillo, Iain W. Chalmers, Mikkel Christensens, Sandra Clifton, Celine Cosseau, Christine Coustau, Richard M. Cripps, Yesid Cuesta-Astroz, Scott F. Cummins, Leon Di Stefano, Nathalie Dinguirard, David Duval, Scott Emrich, Cédric Feschotte, Rene Feyereisen, Peter FitzGerald, Catrina Fronick, Lucinda Fulton, Richard Galinier, Sandra G. Gava, Michael Geusz, Kathrin K. Geyer, Gloria I. Giraldo-Calderón, Matheus de Souza Gomes, Michelle A. Gordy, Benjamin Gourbal, Christoph Grunau, Patrick C. Hanington, Karl F. Hoffmann, Daniel Hughes, Judith Humphries, Daniel J. Jackson, Liana K. Jannotti-Passos, Wander de Jesus Jeremias, Susan Jobling, Bishoy Kamel, Aurélie Kapusta, Satwant Kaur, Joris M. Koene, Andrea B. Kohn, Dan Lawson, Scott P. Lawton, Di Liang, Yanin Limpanont, Sijun Liu, Anne E. Lockyer, Ty Anna L. Lovato, Fernanda Ludolf, Vince Magrini, Donald P. McManus, Monica Medina, Milind Misra, Guillaume Mitta, Gerald M. Mkoji, Michael J. Montague, Cesar Montelongo, Leonid L. Moroz, Monica C. Munoz-Torres, Umar Niazi, Leslie R. Noble, Francislon S. Oliveira, Fabiano S. Pais, Anthony T. Papenfuss, Rob Peace, Janeth J. Pena, Emmanuel A. Pila, Titouan Quelais, Brian J. Raney, Jonathan P. Rast, David Rollinson, Izinara C. Rosse, Bronwyn Rotgans, Edwin J. Routledge, Kathryn M. Ryan, Larissa L. S. Scholte, Kenneth B. Storey, Martin Swain, Jacob A. Tennessen, Chad Tomlinson, Damian L. Trujillo, Emanuela V. Volpi, Anthony J. Walker, Tianfang Wang, Ittiprasert Wannaporn, Wesley C. Warren, Xiao-Jun Wu, Timothy P. Yoshino, Mohammed Yusuf, Si-Ming Zhang, Min Zhao, and Richard K. Wilson
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Science - Abstract
Nature Communications 8: Article number: 15451 (2017); Published 16 May 2017; Updated 23 August 2017 The original version of this Article contained an error in the spelling of the author Leon Di Stefano, which was incorrectly given as Leon di Stephano. This has now been corrected in both the PDF andHTML versions of the Article.
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- 2017
- Full Text
- View/download PDF
5. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region
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Steven R. White, Juan J. Tena, James E. Gern, Débora R. Sobreira, Chanie L. Howard, Kevin M. Magnaye, Carole Ober, Kelly M. Blaine, José Luis Gómez-Skarmeta, Noboru J. Sakabe, Cara L. Hrusch, Anne I. Sperling, Michelle M. Stein, Marcelo A. Nobrega, Edward T. Naureckas, Donna C. Decker, Ivy Aneas, Nathan Schoetler, Lindsey E. Montefiori, Daniel J. Jackson, Douglas K. Hogarth, Matthew C. Altman, Selene M. Clay, and National Institutes of Health (US)
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Male ,Science ,General Physics and Astronomy ,Mice, Transgenic ,Locus (genetics) ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Genome-wide association studies ,Polymorphism, Single Nucleotide ,Article ,General Biochemistry, Genetics and Molecular Biology ,Chromosome conformation capture ,Gene expression ,Animals ,Humans ,Genetic Predisposition to Disease ,Allele ,Promoter Regions, Genetic ,Enhancer ,Alleles ,Zebrafish ,Genetic association ,Genetics ,Multidisciplinary ,Interleukins ,General Chemistry ,Interleukin-33 ,Asthma ,Chromatin ,Gene regulation ,Enhancer Elements, Genetic ,Female ,Octamer Transcription Factor-1 - Abstract
Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as an enhancer-blocking element in vivo and in vitro. Chromatin conformation capture showed that this 5 kb region loops to the IL33 promoter, potentially regulating its expression. We show that the asthma-associated single nucleotide polymorphism (SNP) rs1888909, located within the 5 kb region, is associated with IL33 gene expression in human airway epithelial cells and IL-33 protein expression in human plasma, potentially through differential binding of OCT-1 (POU2F1) to the asthma-risk allele. Our data demonstrate that asthma-associated variants at the IL33 locus mediate allele-specific regulatory activity and IL33 expression, providing a mechanism through which a regulatory SNP contributes to genetic risk of asthma., This work was supported by NIH grants R01 HL118758, R01 HL128075, R01 HL119577, R01 HL085197, U19 AI095230, UG3 OD023282 and UM1 AI114271.
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- 2021
6. FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
- Author
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Michael D. Evans, Daniel J. Jackson, Hans Bisgaard, Tarunveer S. Ahluwalia, Jonas Bybjerg-Grauholm, Merete Nordentoft, Torben Hansen, David M. Hougaard, Anders U. Eliasen, Amitabh Sharma, Preben Bo Mortensen, Anders Gorm Pedersen, Robert F. Lemanske, Marie Bækvad-Hansen, Niels Grarup, Bo L. Chawes, James E. Gern, Jette Bork-Jensen, Jakob Stokholm, Carole Ober, Scott T. Weiss, Klaus Bønnelykke, Allan Linneberg, Ole Mors, Andréanne Morin, Esben Agerbo, Thomas Werge, Casper-Emil T. Pedersen, Karen A. Krogfelt, Oluf Pedersen, Susanne Schjørring, Astrid Sevelsted, and Anders D. Børglum
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Male ,0301 basic medicine ,Exacerbation ,Science ,General Physics and Astronomy ,Genome-wide association study ,medicine.disease_cause ,Polymorphism, Single Nucleotide ,Pneumococcal Infections ,Article ,General Biochemistry, Genetics and Molecular Biology ,ABO Blood-Group System ,03 medical and health sciences ,0302 clinical medicine ,ABO blood group system ,Streptococcus pneumoniae ,Genetics ,Humans ,Medicine ,Genetic Predisposition to Disease ,030212 general & internal medicine ,Early childhood ,Child ,Genetic association study ,Genetic association ,Asthma ,Respiratory tract diseases ,Multidisciplinary ,business.industry ,Genetic interaction ,Case-control study ,Epistasis, Genetic ,General Chemistry ,Fucosyltransferases ,medicine.disease ,respiratory tract diseases ,030104 developmental biology ,Case-Control Studies ,Child, Preschool ,Immunology ,Female ,business ,Genome-Wide Association Study - Abstract
Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically important disease entity through a genome-wide association study. The discovery analysis comprises 2866 children experiencing severe asthma exacerbation between ages 2 and 6 years, and 65,415 non-asthmatic controls, and we replicate findings in 918 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) birth cohorts. We identify rs281379 near FUT2/MAMSTR on chromosome 19 as a novel risk locus (OR = 1.18 (95% CI = 1.11–1.25), Pdiscovery = 2.6 × 10−9) as well as a biologically plausible interaction between functional variants in FUT2 and ABO. We further discover and replicate a potential causal mechanism behind this interaction related to S. pneumoniae respiratory illnesses. These results suggest a novel mechanism of early childhood asthma and demonstrates the importance of phenotype-specificity for discovery of asthma genes and epistasis., Genetic variants discovered through genome-wide association studies for asthma together account for a small portion of the heritability. Here, the authors identify a possible epistatic relationship between coding variants in FUT2 and ABO, especially pronounced in severe and early onset asthma.
- Published
- 2020
7. Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma
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Carole Ober, Jane A. Hoppin, W. James Gauderman, Muhammad T. Salam, Kathleen C. Barnes, Catherine Igartua, James J. Yang, Esteban G. Burchard, Christopher K. Edlund, James E. Gern, Scott T. Weiss, Benjamin A. Raby, Frank D. Gilliland, Albert M. Levin, Stephanie J. London, Rachel A. Myers, Isabelle Romieu, Rasika A. Mathias, Fernando D. Martinez, Blanca E. Del-Rio-Navarro, Oren E. Livne, Nicholas Rafaels, Celeste Eng, L. Keoki Williams, Daniel J. Jackson, Annah B. Wyss, Raphael Mourad, Dan L. Nicolae, Penelope E. Graves, Scott Huntsman, Robert F. Lemanske, and Maria Pino-Yanes
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Male ,Linkage disequilibrium ,Ethnic group ,General Physics and Astronomy ,Genome-wide association study ,Biology ,Article ,Linkage Disequilibrium ,General Biochemistry, Genetics and Molecular Biology ,DNA sequencing ,medicine ,Humans ,Missense mutation ,Genetic Predisposition to Disease ,Gene ,Asthma ,Genetics ,Multidisciplinary ,Membrane Proteins ,General Chemistry ,medicine.disease ,Neoplasm Proteins ,respiratory tract diseases ,3. Good health ,Membrane protein ,Female ,Carrier Proteins ,Genome-Wide Association Study - Abstract
Common variants at many loci have been robustly associated with asthma but explain little of the overall genetic risk. Here we investigate the role of rare (, Common variants account for only a small amount of the heritable risk for developing asthma. Using a meta-analysis approach, Igartua et al. identify one low-frequency missense mutation and two genes with functional variants that are associated with asthma, but only in specific ethnic groups.
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- 2015
8. Correction: Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail
- Author
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René Feyereisen, Olga Baron, Mikkel Christensens, Francislon Silva de Oliveira, Sandra W. Clifton, Scott P Lawton, Mónica Medina, Catrina Fronick, Leonid L. Moroz, Donald P. McManus, Damian L. Trujillo, Edwin J. Routledge, Daniel S.T. Hughes, Joanna M. Bridger, Liana K. Jannotti-Passos, Izinara C Rosse, David Duval, Xiao-Jun Wu, Julia B. Carleton, Joris M. Koene, Larissa L. S. Scholte, Michael J. Montague, Matty Knight, Guilherme Oliveira, Min Zhao, Scott F. Cummins, Benjamin Gourbal, Céline Cosseau, Karl F. Hoffmann, Wesley C. Warren, Christoph Grunau, Peter C. FitzGerald, Janeth J. Pena, Satwant Kaur, Anthony J. Walker, Michelle A. Gordy, Andrea B. Kohn, TyAnna L. Lovato, Richard K. Wilson, Patrick Minx, Christopher J. Bayne, Omar dos Santos Carvalho, Monica Munoz-Torres, Elio Hideo Baba, Wander de Jesus Jeremias, Patrick C. Hanington, Bryony C. Bonning, Maria G. Castillo, Kyle K. Biggar, Kathryn M. Ryan, Rob Peace, Emmanuel A. Pila, Anthony T. Papenfuss, Ittiprasert Wannaporn, Cédric Feschotte, Sarah K. Buddenborg, Gerald M. Mkoji, Umar Niazi, Bronwyn Rotgans, Daniel J. Jackson, Aurélie Kapusta, Michael E. Geusz, Sandra Grossi Gava, Si-Ming Zhang, Nithya Raghavan, Bishoy Kamel, Leon Di Stefano, Emanuela V. Volpi, Chad Tomlinson, Scott J. Emrich, Leslie R. Noble, Di Liang, Gloria I. Giraldo-Calderón, Eric S. Loker, Lucinda Fulton, Matheus de Souza Gomes, Sijun Liu, Richard Galinier, Susan Jobling, Catherine S. Jones, Brian J. Raney, Kenneth B. Storey, Christine Coustau, Martin T. Swain, Yanin Limpanont, Fernanda Ludolf, Roberta Lima Caldeira, Laurence Rodrigues do Amaral, Juliana G Assis, Iain W. Chalmers, Katherine M. Buckley, Milind Misra, Jacob A. Tennessen, Michael S. Blouin, Tianfang Wang, Yesid Cuesta-Astroz, Anne E. Lockyer, Vince Magrini, Kathrin K. Geyer, Daniel Lawson, Richard M. Cripps, Judith E. Humphries, Titouan Quelais, Utibe Bickham-Wright, LaDeana W. Hillier, Andrew M. Shedlock, Chris Botka, Coen M. Adema, Jonathan P. Rast, Halime D. Arican-Goktas, Nathalie Dinguirard, Timothy P. Yoshino, Guillaume Mitta, David Rollinson, Fabiano Sviatopolk-Mirsky Pais, Mohammed Yusuf, and Cesar E. Montelongo
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0301 basic medicine ,Multidisciplinary ,biology ,Ecology ,Published Erratum ,Science ,General Physics and Astronomy ,Schistosomiasis ,General Chemistry ,biology.organism_classification ,medicine.disease ,Genome ,General Biochemistry, Genetics and Molecular Biology ,Freshwater snail ,Spelling ,03 medical and health sciences ,030104 developmental biology ,Evolutionary biology ,medicine - Abstract
Nature Communications 8: Article number: 15451 (2017); Published 16 May 2017; Updated 23 August 2017 The original version of this Article contained an error in the spelling of the author Leon Di Stefano, which was incorrectly given as Leon di Stephano. This has now been corrected in both the PDF andHTML versions of the Article.
- Published
- 2017
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