Search

Your search keyword '"Breeze, Charles E"' showing total 10 results
Start Over Author "Breeze, Charles E" Journal nature communications
10 results on '"Breeze, Charles E"'

1. Genomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident

Author

Morton, Lindsay M., Lee, Olivia W., Karyadi, Danielle M., Bogdanova, Tetiana I., Stewart, Chip, Hartley, Stephen W., Breeze, Charles E., Schonfeld, Sara J., Cahoon, Elizabeth K., Drozdovitch, Vladimir, Masiuk, Sergii, Chepurny, Mykola, Zurnadzhy, Liudmyla Yu, Dai, Jieqiong, Krznaric, Marko, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda D., Dagnall, Casey L., Steinberg, Mia K., Jones, Kristine, Jain, Komal, Jordan, Ben, Machiela, Mitchell J., Dawson, Eric T., Vij, Vibha, Gastier-Foster, Julie M., Bowen, Jay, Mabuchi, Kiyohiko, Hatch, Maureen, Berrington de Gonzalez, Amy, Getz, Gad, Tronko, Mykola D., Thomas, Gerry A., and Chanock, Stephen J.

Published
2024
Full Text
View/download PDF

2. A mammalian methylation array for profiling methylation levels at conserved sequences

Author

Arneson, Adriana, Haghani, Amin, Thompson, Michael J, Pellegrini, Matteo, Kwon, Soo Bin, Vu, Ha, Maciejewski, Emily, Yao, Mingjia, Li, Caesar Z, Lu, Ake T, Morselli, Marco, Rubbi, Liudmilla, Barnes, Bret, Hansen, Kasper D, Zhou, Wanding, Breeze, Charles E, Ernst, Jason, and Horvath, Steve

Subjects
Genetics, Human Genome, Animals, Biomarkers, Conserved Sequence, CpG Islands, DNA Methylation, Epigenesis, Genetic, Humans, Mammals, Mice, Mutation, Protein Processing, Post-Translational, Rats, Transcriptome
Abstract

Infinium methylation arrays are not available for the vast majority of non-human mammals. Moreover, even if species-specific arrays were available, probe differences between them would confound cross-species comparisons. To address these challenges, we developed the mammalian methylation array, a single custom array that measures up to 36k CpGs per species that are well conserved across many mammalian species. We designed a set of probes that can tolerate specific cross-species mutations. We annotate the array in over 200 species and report CpG island status and chromatin states in select species. Calibration experiments demonstrate the high fidelity in humans, rats, and mice. The mammalian methylation array has several strengths: it applies to all mammalian species even those that have not yet been sequenced, it provides deep coverage of conserved cytosines facilitating the development of epigenetic biomarkers, and it increases the probability that biological insights gained in one species will translate to others.

Published
2022

3. Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats

Author

Wilkinson, Gerald S., Adams, Danielle M., Haghani, Amin, Lu, Ake T., Zoller, Joseph, Breeze, Charles E., Arnold, Bryan D., Ball, Hope C., Carter, Gerald G., Cooper, Lisa Noelle, Dechmann, Dina K. N., Devanna, Paolo, Fasel, Nicolas J., Galazyuk, Alexander V., Günther, Linus, Hurme, Edward, Jones, Gareth, Knörnschild, Mirjam, Lattenkamp, Ella Z., Li, Caesar Z., Mayer, Frieder, Reinhardt, Josephine A., Medellin, Rodrigo A., Nagy, Martina, Pope, Brian, Power, Megan L., Ransome, Roger D., Teeling, Emma C., Vernes, Sonja C., Zamora-Mejías, Daniel, Zhang, Joshua, Faure, Paul A., Greville, Lucas J., Herrera M., L. Gerardo, Flores-Martínez, José J., and Horvath, Steve

Published
2022
Full Text
View/download PDF

4. Identical twins carry a persistent epigenetic signature of early genome programming

Author

van Dongen, Jenny, Gordon, Scott D., McRae, Allan F., Odintsova, Veronika V., Mbarek, Hamdi, Breeze, Charles E., Sugden, Karen, Lundgren, Sara, Castillo-Fernandez, Juan E., Hannon, Eilis, Moffitt, Terrie E., Hagenbeek, Fiona A., van Beijsterveldt, Catharina E. M., Jan Hottenga, Jouke, Tsai, Pei-Chien, Min, Josine L., Hemani, Gibran, Ehli, Erik A., Paul, Franziska, Stern, Claudio D., Heijmans, Bastiaan T., Slagboom, P. Eline, Daxinger, Lucia, van der Maarel, Silvère M., de Geus, Eco J. C., Willemsen, Gonneke, Montgomery, Grant W., Reversade, Bruno, Ollikainen, Miina, Kaprio, Jaakko, Spector, Tim D., Bell, Jordana T., Mill, Jonathan, Caspi, Avshalom, Martin, Nicholas G., and Boomsma, Dorret I.

Published
2021
Full Text
View/download PDF

5. DNA methylation predicts age and provides insight into exceptional longevity of bats

Author

Wilkinson, Gerald S., Adams, Danielle M., Haghani, Amin, Lu, Ake T., Zoller, Joseph, Breeze, Charles E., Arnold, Bryan D., Ball, Hope C., Carter, Gerald G., Cooper, Lisa Noelle, Dechmann, Dina K. N., Devanna, Paolo, Fasel, Nicolas J., Galazyuk, Alexander V., Günther, Linus, Hurme, Edward, Jones, Gareth, Knörnschild, Mirjam, Lattenkamp, Ella Z., Li, Caesar Z., Mayer, Frieder, Reinhardt, Josephine A., Medellin, Rodrigo A., Nagy, Martina, Pope, Brian, Power, Megan L., Ransome, Roger D., Teeling, Emma C., Vernes, Sonja C., Zamora-Mejías, Daniel, Zhang, Joshua, Faure, Paul A., Greville, Lucas J., Herrera M., L. Gerardo, Flores-Martínez, José J., and Horvath, Steve

Published
2021
Full Text
View/download PDF

6. Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats

Author

Wilkinson, Gerald S., Adams, Danielle M., Haghani, Amin, Lu, Ake T., Zoller, Joseph, Breeze, Charles E., Arnold, Bryan D., Ball, Hope C., Carter, Gerald G., Cooper, Lisa Noelle, Dechmann, Dina K. N., Devanna, Paolo, Fasel, Nicolas J., Galazyuk, Alexander V., Günther, Linus, Hurme, Edward, Jones, Gareth, Knörnschild, Mirjam, Lattenkamp, Ella Z., Li, Caesar Z., Mayer, Frieder, Reinhardt, Josephine A., Medellin, Rodrigo A., Nagy, Martina, Pope, Brian, Power, Megan L., Ransome, Roger D., Teeling, Emma C., Vernes, Sonja C., Zamora-Mejías, Daniel, Zhang, Joshua, Faure, Paul A., Greville, Lucas J., Horvath, Steve, Herrera M., L. Gerardo, and Flores-Martínez, José J.

Published
2021
Full Text
View/download PDF

7. DNA methylation predicts age and provides insight into exceptional longevity of bats.

Author

Wilkinson, Gerald S., Adams, Danielle M., Haghani, Amin, Lu, Ake T., Zoller, Joseph, Breeze, Charles E., Arnold, Bryan D., Ball, Hope C., Carter, Gerald G., Cooper, Lisa Noelle, Dechmann, Dina K. N., Devanna, Paolo, Fasel, Nicolas J., Galazyuk, Alexander V., Günther, Linus, Hurme, Edward, Jones, Gareth, Knörnschild, Mirjam, Lattenkamp, Ella Z., and Li, Caesar Z.

Subjects
LONGEVITY, DNA methylation, AGE, BATS, PROMOTERS (Genetics), GENETIC transcription regulation
Abstract

Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression. DNA methylation profiles from 26 bat species accurately predicts chronological age, while longevity-related methylation patterns across the genome suggest that bat longevity results from augmented immune response and cancer suppression. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

8. Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Author

Bartlett, Thomas E., Chindera, Kantaraja, McDermott, Jacqueline, Breeze, Charles E., Cooke, William R., Jones, Allison, Reisel, Daniel, Karegodar, Smita T., Arora, Rupali, Beck, Stephan, Menon, Usha, Dubeau, Louis, and Widschwendter, Martin

Subjects
Adult, animal structures, Time Factors, endocrine system diseases, Adolescent, Carcinogenesis, Science, Ovariectomy, Primary Cell Culture, Article, Epithelium, Epigenesis, Genetic, Young Adult, Neoplasms, Cell Line, Tumor, Cytidine Deaminase, Humans, skin and connective tissue diseases, Fallopian Tubes, Aged, Retrospective Studies, Aged, 80 and over, BRCA2 Protein, Ovarian Neoplasms, BRCA1 Protein, Epithelial Cells, DNA Methylation, Middle Aged, female genital diseases and pregnancy complications, Mutation, CpG Islands, Female, Biomarkers
Abstract

The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30–40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise referred to as ‘ovarian carcinomas', which frequently develop from fimbrial cells but not from the proximal portion of the fallopian tube. Here we compare the DNA methylome of the fimbrial and proximal ends of the fallopian tube in BRCA1/2 mutation carriers and non-carriers. We show that the number of CpGs displaying significant differences in methylation levels between fimbrial and proximal fallopian tube segments are threefold higher in BRCA mutation carriers than in controls, correlating with overexpression of activation-induced deaminase in their fimbrial epithelium. The differentially methylated CpGs accurately discriminate HGSEMCs from non-serous subtypes. Epigenetic reprogramming is an early pre-malignant event integral to BRCA1/2 mutation-driven carcinogenesis. Our findings may provide a basis for cancer-preventative strategies., Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCA mutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.

Published
2015

9. Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Author

Bartlett, Thomas E., primary, Chindera, Kantaraja, additional, McDermott, Jacqueline, additional, Breeze, Charles E., additional, Cooke, William R., additional, Jones, Allison, additional, Reisel, Daniel, additional, Karegodar, Smita T., additional, Arora, Rupali, additional, Beck, Stephan, additional, Menon, Usha, additional, Dubeau, Louis, additional, and Widschwendter, Martin, additional

Published
2016
Full Text
View/download PDF

10. Genetic and environmental influences interact with age and sex in shaping the human methylome.

Author

van Dongen, Jenny, Nivard, Michel G., Willemsen, Gonneke, Hottenga, Jouke-Jan, Helmer, Quinta, Dolan, Conor V., Ehli, Erik A., Davies, Gareth E., van Iterson, Maarten, Breeze, Charles E., Beck, Stephan, Eka Suchiman, H., Jansen, Rick, van Meurs, Joyce B., Heijmans, Bastiaan T., Eline Slagboom, P., Boomsma, Dorret I., Hoen, Peter A. C. 't, Pool, René, and van Greevenbroek, Marleen M. J.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results