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Start Over Author "Bedoya, Gabriel" Journal nature communications
5 results on '"Bedoya, Gabriel"'

1. A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

Author

Adhikari, Kaustubh, Mendoza-Revilla, Javier, Sohail, Anood, Fuentes-Guajardo, Macarena, Lampert, Jodie, Chacón-Duque, Juan Camilo, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Acuña-Alonzo, Victor, Jaramillo, Claudia, Arias, William, Lozano, Rodrigo Barquera, Everardo, Paola, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Silva de Cerqueira, Caio C., Hunemeier, Tábita, Ramallo, Virginia, Schuler-Faccini, Lavinia, Salzano, Francisco M., Gonzalez-José, Rolando, Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Bedoya, Gabriel, Rothhammer, Francisco, Tobin, Desmond J., Fumagalli, Matteo, Balding, David, and Ruiz-Linares, Andrés

Published
2019
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2. Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Author

Chacón-Duque, Juan-Camilo, Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Mendoza-Revilla, Javier, Acuña-Alonzo, Victor, Barquera, Rodrigo, Quinto-Sánchez, Mirsha, Gómez-Valdés, Jorge, Everardo Martínez, Paola, Villamil-Ramírez, Hugo, Hünemeier, Tábita, Ramallo, Virginia, Silva de Cerqueira, Caio C., Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Villena, Mercedes, Vásquez, René, Llop, Elena, Sandoval, José R., Salazar-Granara, Alberto A., Parolin, Maria-Laura, Sandoval, Karla, Peñaloza-Espinosa, Rosenda I., Rangel-Villalobos, Hector, Winkler, Cheryl A., Klitz, William, Bravi, Claudio, Molina, Julio, Corach, Daniel, Barrantes, Ramiro, Gomes, Verónica, Resende, Carlos, Gusmão, Leonor, Amorim, Antonio, Xue, Yali, Dugoujon, Jean-Michel, Moral, Pedro, González-José, Rolando, Schuler-Faccini, Lavinia, Salzano, Francisco M., Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Poletti, Giovanni, Gallo, Carla, Bedoya, Gabriel, Rothhammer, Francisco, Balding, David, Hellenthal, Garrett, and Ruiz-Linares, Andrés

Published
2018
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3. A genome-wide association study identifies multiple loci for variation in human ear morphology

Author

Adhikari, Kaustubh, Reales, Guillermo, Smith, Andrew J. P., Konka, Esra, Palmen, Jutta, Quinto-Sanchez, Mirsha, Acuña-Alonzo, Victor, Jaramillo, Claudia, Arias, William, Fuentes, Macarena, Pizarro, María, Barquera Lozano, Rodrigo, Macín Pérez, Gastón, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Hunemeier, Tábita, Ramallo, Virginia, Silva de Cerqueira, Caio C., Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Gallo, Carla, Poletti, Giovanni, Schuler-Faccini, Lavinia, Salzano, Francisco M., Bortolini, Maria- Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Bedoya, Gabriel, Calderón, Rosario, Rosique, Javier, Cheeseman, Michael, Bhutta, Mahmood F., Humphries, Steve E., Gonzalez-José, Rolando, Headon, Denis, Balding, David, and Ruiz-Linares, Andrés

Subjects
Adult, Male, Adolescent, Genotype, purl.org/pe-repo/ocde/ford#1.06.03 [https], purl.org/pe-repo/ocde/ford#1.03.00 [https], Polymorphism, Single Nucleotide, Article, White People, Ciencias Biológicas, purl.org/becyt/ford/1 [https], Genética y Herencia, Mice, Young Adult, Cell Line, Tumor, Morphogenesis, Homeodomain Proteins/metabolism, Animals, Humans, European Continental Ancestry Group/genetics, purl.org/becyt/ford/1.6 [https], American Indian or Alaska Native, T-Box Domain Proteins/genetics/metabolism, pinna morphology, Homeodomain Proteins, American Native Continental Ancestry Group/genetics, Edar Receptor, Morphogenesis/genetics, EDAR, Edar Receptor/genetics, Latin America, Phenotype, Ear Auricle/anatomy & histology/embryology, purl.org/pe-repo/ocde/ford#1.04.00 [https], genome-wide association, Female, T-Box Domain Proteins, CIENCIAS NATURALES Y EXACTAS, Ear Auricle, Genome-Wide Association Study
Abstract

Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find genome-wide significant association at seven genomic regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion and antitragus size (linear regression P values 2 × 10−8 to 3 × 10−14). Four traits are associated with a functional variant in the Ectodysplasin A receptor (EDAR) gene, a key regulator of embryonic skin appendage development. We confirm expression of Edar in the developing mouse ear and that Edar-deficient mice have an abnormally shaped pinna. Two traits are associated with SNPs in a region overlapping the T-Box Protein 15 (TBX15) gene, a major determinant of mouse skeletal development. Strongest association in this region is observed for SNP rs17023457 located in an evolutionarily conserved binding site for the transcription factor Cartilage paired-class homeoprotein 1 (CART1), and we confirm that rs17023457 alters in vitro binding of CART1., The shape of the pinna varies widely in the general human population but the genetic basis of this variation is unknown. Here Adhikari et al. conduct a genome-wide association study in Latin Americans and discover seven gene regions influencing pinna morphology, including EDAR and TBX15.

Published
2015

4. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Author

Adhikari, Kaustubh, primary, Fuentes-Guajardo, Macarena, additional, Quinto-Sánchez, Mirsha, additional, Mendoza-Revilla, Javier, additional, Camilo Chacón-Duque, Juan, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Lozano, Rodrigo Barquera, additional, Pérez, Gastón Macín, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Silva de Cerqueira, Caio C., additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Bortolini, Maria- Cátira, additional, Canizales-Quinteros, Samuel, additional, Cheeseman, Michael, additional, Rosique, Javier, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Headon, Denis, additional, González-José, Rolando, additional, Balding, David, additional, and Ruiz-Linares, Andrés, additional

Published
2016
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5. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

Author

Adhikari, Kaustubh, primary, Fontanil, Tania, additional, Cal, Santiago, additional, Mendoza-Revilla, Javier, additional, Fuentes-Guajardo, Macarena, additional, Chacón-Duque, Juan-Camilo, additional, Al-Saadi, Farah, additional, Johansson, Jeanette A., additional, Quinto-Sanchez, Mirsha, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Barquera Lozano, Rodrigo, additional, Macín Pérez, Gastón, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Silva de Cerqueira, Caio C., additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Rothhammer, Francisco, additional, Bedoya, Gabriel, additional, Gonzalez-José, Rolando, additional, Headon, Denis, additional, López-Otín, Carlos, additional, Tobin, Desmond J., additional, Balding, David, additional, and Ruiz-Linares, Andrés, additional

Published
2016
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