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71 results on '"Attard P"'

1. Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer

Author

Kiviaho, Antti, Eerola, Sini K., Kallio, Heini M. L., Andersen, Maria K., Hoikka, Miina, Tiihonen, Aliisa M., Salonen, Iida, Spotbeen, Xander, Giesen, Alexander, Parker, Charles T. A., Taavitsainen, Sinja, Hantula, Olli, Marttinen, Mikael, Hermelo, Ismaïl, Ismail, Mazlina, Midtbust, Elise, Wess, Maximilian, Devlies, Wout, Sharma, Abhibhav, Krossa, Sebastian, Häkkinen, Tomi, Afyounian, Ebrahim, Vandereyken, Katy, Kint, Sam, Kesseli, Juha, Tolonen, Teemu, Tammela, Teuvo L. J., Viset, Trond, Størkersen, Øystein, Giskeødegård, Guro F., Rye, Morten B., Murtola, Teemu, Erickson, Andrew, Latonen, Leena, Bova, G. Steven, Mills, Ian G., Joniau, Steven, Swinnen, Johannes V., Voet, Thierry, Mirtti, Tuomas, Attard, Gerhardt, Claessens, Frank, Visakorpi, Tapio, Rautajoki, Kirsi J., Tessem, May-Britt, Urbanucci, Alfonso, and Nykter, Matti

Published
2024
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3. Copy number architectures define treatment-mediated selection of lethal prostate cancer clones

Author

Hasan, A. M. Mahedi, Cremaschi, Paolo, Wetterskog, Daniel, Jayaram, Anuradha, Wong, Stephen Q., Williams, Scott, Pasam, Anupama, Trigos, Anna, Trujillo, Blanca, Grist, Emily, Friedrich, Stefanie, Vainauskas, Osvaldas, Parry, Marina, Ismail, Mazlina, Devlies, Wout, Wingate, Anna, Linch, Mark, Naceur-Lombardelli, Cristina, Swanton, Charles, Jamal-Hanjani, Mariam, Lise, Stefano, Sandhu, Shahneen, and Attard, Gerhardt

Published
2023
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7. Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Author

Taavitsainen, S., Engedal, N., Cao, S., Handle, F., Erickson, A., Prekovic, S., Wetterskog, D., Tolonen, T., Vuorinen, E. M., Kiviaho, A., Nätkin, R., Häkkinen, T., Devlies, W., Henttinen, S., Kaarijärvi, R., Lahnalampi, M., Kaljunen, H., Nowakowska, K., Syvälä, H., Bläuer, M., Cremaschi, P., Claessens, F., Visakorpi, T., Tammela, T. L. J., Murtola, T., Granberg, K. J., Lamb, A. D., Ketola, K., Mills, I. G., Attard, G., Wang, W., Nykter, M., and Urbanucci, A.

Published
2021
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8. Transplantation of discarded livers following viability testing with normothermic machine perfusion

Author

Mergental, Hynek, Laing, Richard W., Kirkham, Amanda J., Perera, M. Thamara P. R., Boteon, Yuri L., Attard, Joseph, Barton, Darren, Curbishley, Stuart, Wilkhu, Manpreet, Neil, Desley A. H., Hübscher, Stefan G., Muiesan, Paolo, Isaac, John R., Roberts, Keith J., Abradelo, Manuel, Schlegel, Andrea, Ferguson, James, Cilliers, Hentie, Bion, Julian, Adams, David H., Morris, Chris, Friend, Peter J., Yap, Christina, Afford, Simon C., and Mirza, Darius F.

Published
2020
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9. Nanobubbles explain the large slip observed on lubricant-infused surfaces.

Author

Vega-Sánchez C, Peppou-Chapman S, Zhu L, and Neto C

Abstract

Lubricant-infused surfaces hold promise to reduce the huge frictional drag that slows down the flow of fluids at microscales. We show that infused Teflon wrinkled surfaces induce an effective slip length 50 times larger than expected based on the presence of the lubricant alone. This effect is particularly striking as it occurs even when the infused lubricant's viscosity is several times higher than that of the flowing liquid. Crucially, the slip length increases with increasing air content in the water but is much higher than expected even in degassed and plain Milli-Q water. Imaging directly the immersed interface using a mapping technique based on atomic force microscopy meniscus force measurements reveals that the mechanism responsible for this huge slip is the nucleation of surface nanobubbles. Using a numerical model and the height and distribution of these surface nanobubbles, we can quantitatively explain the large fluid slip observed in these surfaces., (© 2022. The Author(s).)

Published
2022
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10. Dehydration regulates structural reorganization of dynamic hydrogels.

Author

Xu D, Meng X, Liu S, Poisson J, Vana P, and Zhang K

Abstract

The dehydration process is widely recognized as a significant phenomenon in nature. Hydrogels, which are important functional materials with high water content and crosslinked networks, encounter the issue of dehydration in their practical applications. Here, we report the distinctive anisotropic dehydration modality of dynamic hydrogels, which is fundamentally different from the more commonly observed isotropic dehydration of covalent hydrogels. Xerogels derived from dynamic hydrogel dehydration will fully cover a curved substrate surface and exhibit hollow structures with internal knots, in contrast to the bulk xerogels produced by covalent hydrogel dehydration. Depending on the competing cohesion of polymer chains and the adhesion at the hydrogel-substrate interface, the previously overlooked reorganization of polymer networks within dynamic hydrogels, triggered by dehydration-induced stress, has been discovered to regulate such macroscopic structural reconstruction for dynamic hydrogel dehydration. With the attached hydrogel-substrate interface, the surface microstructures of substrates can also be engraved onto xerogels with high resolution and on a large scale. This work will greatly enhance our understanding of the soft matter dehydration process and broaden the applications of dehydration technologies using water-containing materials., (© 2024. The Author(s).)

Published
2024
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11. Superheating of grain boundaries within bulk colloidal crystals.

Author

Xiao, Xiuming, Wang, Lilin, Wang, Zhijun, and Wang, Ziren

Subjects
CRYSTAL grain boundaries, MELTING points, DIFFUSION coefficients, HOMOGENEOUS nucleation, COLLOIDAL crystals, HETEROGENOUS nucleation, MECHANICAL behavior of materials
Abstract

Whether grain boundaries (GBs) premelt is a longstanding question, because of the difficulty of direct experimental tests. Here, we focused an optical beam to locally heat single GBs within bulk hard-sphere colloidal crystals, observing the melting dynamics at single-particle resolution by video microscopy. The melting point is determined by analysing both the Lindemann parameter and the critical nucleus size for homogeneous nucleation. We found that all the GBs, including the high-energy GBs, can be superheated and melt via a heterogeneous nucleation mechanism. Based on the classical nucleation theory of GBs, we measured the incubation time and contact angle of the critical nucleus to compute all relevant kinetic factors, as well as the energy barrier, nucleation rate and the diffusion coefficient at the solid–liquid interface under weak superheating. The superheat limits of GBs with various misorientations have also been measured to further explore the instability mechanism. Under traditional uniform heating, premelting occurs only at triple junctions, whereas GBs retain their original structures up to the melting point. The premelted regions at triple junctions further interrupt high-energy GBs from superheating, through intrusion by uniform liquid layers. Overall, our experiments confirm the existence of superheating of GBs. Understanding the dynamics of grain boundaries and their melting behaviour is important for controlling the mechanical properties of materials. Now, experiments show that grain boundaries can be superheated, and that they melt via a nucleation mechanism. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Engineering a passivating electric double layer for high performance lithium metal batteries.

Author

Zhang, Weili, Lu, Yang, Wan, Lei, Zhou, Pan, Xia, Yingchun, Yan, Shuaishuai, Chen, Xiaoxia, Zhou, Hangyu, Dong, Hao, and Liu, Kai

Subjects
ELECTRIC double layer, SOLID state batteries, LITHIUM cells, SUPRAMOLECULAR polymers, POLYMER structure, HIGH voltages, ELECTRIC batteries
Abstract

In electrochemical devices, such as batteries, traditional electric double layer (EDL) theory holds that cations in the cathode/electrolyte interface will be repelled during charging, leaving a large amount of free solvents. This promotes the continuous anodic decomposition of the electrolyte, leading to a limited operation voltage and cycle life of the devices. In this work, we design a new EDL structure with adaptive and passivating properties. It is enabled by adding functional anionic additives in the electrolyte, which can selectively bind with cations and free solvents, forming unique cation-rich and branch-chain like supramolecular polymer structures with high electrochemical stability in the EDL inner layer. Due to this design, the anodic decomposition of ether-based electrolytes is significantly suppressed in the high voltage cathodes and the battery shows outstanding performances such as super-fast charging/discharging and ultra-low temperature applications, which is extremely hard in conventional electrolyte design principle. This unconventional EDL structure breaks the inherent perception of the classical EDL rearrangement mechanism and greatly improve electrochemical performances of the device. Developing an electrolyte that is compatible with both high-voltage cathodes and Li metal anodes has always been challenging. Here, the authors created a new strategy by engineering a passivating electric double layer to achieve a fast-charging and lowtemperature high voltage lithium metal batteries. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Substrate colonization by an emulsion drop prior to spreading.

Author

Borkar, Suraj and Ramachandran, Arun

Subjects
COLONIZATION (Ecology), FLOTATION, EMULSIONS, MULTIPHASE flow, SOLUBILITY
Abstract

In classical wetting, the spreading of an emulsion drop on a surface is preceded by the formation of a bridge connecting the drop and the surface across the sandwiched film of the suspending medium. However, this widely accepted mechanism ignores the finite solubility of the drop phase in the medium. We present experimental evidence of a new wetting mechanism, whereby the drop dissolves in the medium, and nucleates on the surface as islands that grow with time. Island growth is predicated upon a reduction in solubility near the contact line due to attractive interactions between the drop and the surface, overcoming Ostwald ripening. Ultimately, wetting is manifested as a coalescence event between the parent drop and one of the islands, which can result in significantly large critical film heights and short hydrodynamic drainage times prior to wetting. This discovery has broad relevance in areas such as froth flotation, liquid-infused surfaces, multiphase flows and microfluidics. In classical wetting, the spreading of a drop on a surface is preceded by a bridge directly connecting the drop and the surface, yet it ignores the solubility of the drop phase in the medium. Here, the authors show that dissolved drop fluid from the parent drop can nucleate on the surface as islands, one of which coalesces with the parent drop to effect wetting. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Super liquid repellent surfaces for anti-foaming and froth management.

Author

Wong, William S. Y., Naga, Abhinav, Hauer, Lukas, Baumli, Philipp, Bauer, Hoimar, Hegner, Katharina I., D'Acunzi, Maria, Kaltbeitzel, Anke, Butt, Hans-Jürgen, and Vollmer, Doris

Subjects
LIQUID surfaces, FOAM, MANUFACTURING processes, AQUEOUS solutions, INDUSTRIAL management, CHEMICAL industry
Abstract

Wet and dry foams are prevalent in many industries, ranging from the food processing and commercial cosmetic sectors to industries such as chemical and oil-refining. Uncontrolled foaming results in product losses, equipment downtime or damage and cleanup costs. To speed up defoaming or enable anti-foaming, liquid oil or hydrophobic particles are usually added. However, such additives may need to be later separated and removed for environmental reasons and product quality. Here, we show that passive defoaming or active anti-foaming is possible simply by the interaction of foam with chemically or morphologically modified surfaces, of which the superamphiphobic variant exhibits superior performance. They significantly improve retraction of highly stable wet foams and prevention of growing dry foams, as quantified for beer and aqueous soap solution as model systems. Microscopic imaging reveals that amphiphobic nano-protrusions directly destabilize contacting foam bubbles, which can favorably vent through air gaps warranted by a Cassie wetting state. This mode of interfacial destabilization offers untapped potential for developing efficient, low-power and sustainable foam and froth management. Wong et al. demonstrate the efficacy of super-amphiphobic surfaces for in situ defoaming and inhibition of foam growth while handling aqueous solutions. Without the use of chemical additives, their passive approach suggests a facile alternative route to froth management in industrial processes. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer

Author

Vandekerkhove, Gillian, Lavoie, Jean-Michel, Annala, Matti, Murtha, Andrew J., Sundahl, Nora, Walz, Simon, Sano, Takeshi, Taavitsainen, Sinja, Ritch, Elie, Fazli, Ladan, Hurtado-Coll, Antonio, Wang, Gang, Nykter, Matti, Black, Peter C., Todenhöfer, Tilman, Ost, Piet, Gibb, Ewan A., Chi, Kim N., Eigl, Bernhard J., and Wyatt, Alexander W.

Published
2021
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16. The telomere length landscape of prostate cancer

Author

Livingstone, Julie, Shiah, Yu-Jia, Yamaguchi, Takafumi N., Heisler, Lawrence E., Huang, Vincent, Lesurf, Robert, Gebo, Tsumugi, Carlin, Benjamin, Eng, Stefan, Drysdale, Erik, Green, Jeffrey, van der Kwast, Theodorus, Bristow, Robert G., Fraser, Michael, and Boutros, Paul C.

Published
2021
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17. A case report of multiple primary prostate tumors with differential drug sensitivity

Author

Wilkinson, Scott, Harmon, Stephanie A., Terrigino, Nicholas T., Karzai, Fatima, Pinto, Peter A., Madan, Ravi A., VanderWeele, David J., Lake, Ross, Atway, Rayann, Bright, John R., Carrabba, Nicole V., Trostel, Shana Y., Lis, Rosina T., Chun, Guinevere, Gulley, James L., Merino, Maria J., Choyke, Peter L., Ye, Huihui, Dahut, William L., Turkbey, Baris, and Sowalsky, Adam G.

Published
2020
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18. Pairwise frictional profile between particles determines discontinuous shear thickening transition in non-colloidal suspensions.

Author

Comtet, Jean, Chatté, Guillaume, Niguès, Antoine, Bocquet, Lydéric, Siria, Alessandro, and Colin, Annie

Abstract

The process by which sheared suspensions go through a dramatic change in viscosity is known as discontinuous shear thickening. Although well-characterized on the macroscale, the microscopic mechanisms at play in this transition are still poorly understood. Here, by developing new experimental procedures based on quartz-tuning fork atomic force microscopy, we measure the pairwise frictional profile between approaching pairs of polyvinyl chloride and cornstarch particles in solvent. We report a clear transition from a low-friction regime, where pairs of particles support a finite normal load, while interacting purely hydrodynamically, to a high-friction regime characterized by hard repulsive contact between the particles and sliding friction. Critically, we show that the normal stress needed to enter the frictional regime at nanoscale matches the critical stress at which shear thickening occurs for macroscopic suspensions. Our experiments bridge nano and macroscales and provide long needed demonstration of the role of frictional forces in discontinuous shear thickening. [ABSTRACT FROM AUTHOR]

Published
2017
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22. “Pink power”—the importance of coralline algal beds in the oceanic carbon cycle

Author

Schubert, Nadine, Tuya, Fernando, Peña, Viviana, Horta, Paulo A., Salazar, Vinícius W., Neves, Pedro, Ribeiro, Cláudia, Otero-Ferrer, Francisco, Espino, Fernando, Schoenrock, Kathryn, Ragazzola, Federica, Olivé, Irene, Giaccone, Thalassia, Nannini, Matteo, Mangano, M. Cristina, Sará, Gianluca, Mancuso, Francesco Paolo, Tantillo, Mario Francesco, Bosch-Belmar, Mar, Martin, Sophie, Le Gall, Line, Santos, Rui, and Silva, João

Published
2024
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24. Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer

Author

Cacciatore, Alessia, Shinde, Dheeraj, Musumeci, Carola, Sandrini, Giada, Guarrera, Luca, Albino, Domenico, Civenni, Gianluca, Storelli, Elisa, Mosole, Simone, Federici, Elisa, Fusina, Alessio, Iozzo, Marta, Rinaldi, Andrea, Pecoraro, Matteo, Geiger, Roger, Bolis, Marco, Catapano, Carlo V., and Carbone, Giuseppina M.

Published
2024
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33. Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance

Author

Rasool, Reyaz ur, O’Connor, Caitlin M., Das, Chandan Kanta, Alhusayan, Mohammed, Verma, Brijesh Kumar, Islam, Sehbanul, Frohner, Ingrid E., Deng, Qu, Mitchell-Velasquez, Erick, Sangodkar, Jaya, Ahmed, Aqila, Linauer, Sarah, Mudrak, Ingrid, Rainey, Jessica, Zawacki, Kaitlin P., Suhan, Tahra K., Callahan, Catherine G., Rebernick, Ryan, Natesan, Ramakrishnan, Siddiqui, Javed, Sauter, Guido, Thomas, Dafydd, Wang, Shaomeng, Taylor, Derek J., Simon, Ronald, Cieslik, Marcin, Chinnaiyan, Arul M., Busino, Luca, Ogris, Egon, Narla, Goutham, and Asangani, Irfan A.

Published
2023
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38. Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity

Author

Westbrook, Thomas C., Guan, Xiangnan, Rodansky, Eva, Flores, Diana, Liu, Chia Jen, Udager, Aaron M., Patel, Radhika A., Haffner, Michael C., Hu, Ya-Mei, Sun, Duanchen, Beer, Tomasz M., Foye, Adam, Aggarwal, Rahul, Quigley, David A., Youngren, Jack F., Ryan, Charles J., Gleave, Martin, Wang, Yuzhuo, Huang, Jiaoti, Coleman, Ilsa, Morrissey, Colm, Nelson, Peter S., Evans, Christopher P., Lara, Primo, Reiter, Robert E., Witte, Owen, Rettig, Matthew, Wong, Christopher K., Weinstein, Alana S., Uzunangelov, Vlado, Stuart, Josh M., Thomas, George V., Feng, Felix Y., Small, Eric J., Yates, Joel A., Xia, Zheng, and Alumkal, Joshi J.

Published
2022
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49. Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Author

Faugeroux, Vincent, Pailler, Emma, Oulhen, Marianne, Deas, Olivier, Brulle-Soumare, Laura, Hervieu, Céline, Marty, Virginie, Alexandrova, Kamelia, Andree, Kiki C., Stoecklein, Nikolas H., Tramalloni, Dominique, Cairo, Stefano, NgoCamus, Maud, Nicotra, Claudio, Terstappen, Leon W. M. M., Manaresi, Nicolo, Lapierre, Valérie, Fizazi, Karim, Scoazec, Jean-Yves, Loriot, Yohann, Judde, Jean-Gabriel, and Farace, Françoise

Published
2020
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