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Start Over Author "Anna Honko" Journal nature communications
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1. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

Author

Matthew R. Chang, Luke Tomasovic, Natalia A. Kuzmina, Adam J. Ronk, Patrick O. Byrne, Rebecca Johnson, Nadia Storm, Eduardo Olmedillas, Yixuan J. Hou, Alexandra Schäfer, Sarah R. Leist, Longping V. Tse, Hanzhong Ke, Christian Coherd, Katrina Nguyen, Maliwan Kamkaew, Anna Honko, Quan Zhu, Galit Alter, Erica Ollmann Saphire, Jason S. McLellan, Anthony Griffiths, Ralph S. Baric, Alexander Bukreyev, and Wayne A. Marasco

Subjects
Science
Abstract

COVID-19 can be treated with monoclonal antibodies against SARS-CoV-2, but emerging new variants might show resistance towards existing therapy. Here authors show that anti-SARS-CoV-2 spike human single-chain antibody fragments could gain neutralizing activity against variants of concern upon engineering into a human bispecific antibody.

Published
2022
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