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Start Over Author "Angela M Phillips" Journal nature communications
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1. Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1

Author

Alief Moulana, Thomas Dupic, Angela M. Phillips, Jeffrey Chang, Serafina Nieves, Anne A. Roffler, Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, and Michael M. Desai

Subjects
Science
Abstract

Evolution of the SARS-CoV-2 spike protein is likely driven by many factors, including immune escape and receptor binding. Here, by measuring the binding affinity of more than 30,000 variants of the SARS-CoV-2 RBD to its receptor ACE2, Moulana et al. show that the evolution of the Omicron BA.1 variant was driven by interactions between mutations.

Published
2022
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