9 results on '"Andersen, Kristian G."'
Search Results
2. SARS-CoV-2 genomic surveillance in wastewater as a model for monitoring evolution of endemic viruses
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Yousif, Mukhlid, Rachida, Said, Taukobong, Setshaba, Ndlovu, Nkosenhle, Iwu-Jaja, Chinwe, Howard, Wayne, Moonsamy, Shelina, Mhlambi, Nompilo, Gwala, Sipho, Levy, Joshua I., Andersen, Kristian G., Scheepers, Cathrine, von Gottberg, Anne, Wolter, Nicole, Bhiman, Jinal N., Amoako, Daniel Gyamfi, Ismail, Arshad, Suchard, Melinda, and McCarthy, Kerrigan
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- 2023
- Full Text
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3. Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria
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Olawoye, Idowu B., Oluniyi, Paul E., Oguzie, Judith U., Uwanibe, Jessica N., Kayode, Tolulope A., Olumade, Testimony J., Ajogbasile, Fehintola V., Parker, Edyth, Eromon, Philomena E., Abechi, Priscilla, Sobajo, Tope A., Ugwu, Chinedu A., George, Uwem E., Ayoade, Femi, Akano, Kazeem, Oyejide, Nicholas E., Nosamiefan, Iguosadolo, Fred-Akintunwa, Iyanuoluwa, Adedotun-Sulaiman, Kemi, Brimmo, Farida B., Adegboyega, Babatunde B., Philip, Courage, Adeleke, Richard A., Chukwu, Grace C., Ahmed, Muhammad I., Ope-Ewe, Oludayo O., Otitoola, Shobi G., Ogunsanya, Olusola A., Saibu, Mudasiru F., Sijuwola, Ayotunde E., Ezekiel, Grace O., John, Oluwagboadurami G., Akin-John, Julie O., Akinlo, Oluwasemilogo O., Fayemi, Olanrewaju O., Ipaye, Testimony O., Nwodo, Deborah C., Omoniyi, Abolade E., Omwanghe, Iyobosa B., Terkuma, Christabel A., Okolie, Johnson, Ayo-Ale, Olubukola, Ikponmwosa, Odia, Benevolence, Ebo, Naregose, Grace O., Patience, Akhilomen E., Blessing, Osiemi, Micheal, Airende, Jacqueline, Agbukor, Aiyepada, John O., Ebhodaghe, Paulson, Racheal, Omiunu, Rita, Esumeh, Rosemary, Giwa E., Solomon, Ehikhametalor, Anieno, Ekanem, Edna, Yerumoh, Chris, Aire O., Donatus, Adomeh I., Ogbaini-Emovon, Ephraim, Tatfeng, Mirabeau Y., Omunakwe, Hannah E., Bob-Manuel, Mienye, Ahmed, Rahaman A., Onwuamah, Chika K., Shaibu, Joseph O., Okwuraiwe, Azuka, Ataga, Anthony E., Bock-Oruma, Andrew, Daramola, Funmi, Yusuf, Ibrahim F., Fajola, Akinwumi, Ntia, Nsikak-Abasi, Ekpo, Julie J., Moses, Anietie E., Moore-Igwe, Beatrice W., Fakayode, Oluwatosin E., Akinola, Monilade, Kida, Ibrahim M., Oderinde, Bamidele S., Wudiri, Zara W., Adeyemi, Oluwapelumi O., Akanbi, Olusola A., Ahumibe, Anthony, Akinpelu, Afolabi, Ayansola, Oyeronke, Babatunde, Olajumoke, Omoare, Adesuyi A., Chukwu, Chimaobi, Mba, Nwando G., Omoruyi, Ewean C., Olisa, Olasunkanmi, Akande, Olatunji K., Nwafor, Ifeanyi E., Ekeh, Matthew A., Ndoma, Erim, Ewah, Richard L., Duruihuoma, Rosemary O., Abu, Augustine, Odeh, Elizabeth, Onyia, Venatius, Ojide, Chiedozie K., Okoro, Sylvanus, Igwe, Daniel, Ogah, Emeka O., Khan, Kamran, Ajayi, Nnennaya A., Ugwu, Collins N., Ukwaja, Kingsley N., Ugwu, Ngozi I., Abejegah, Chukwuyem, Adedosu, Nelson, Ayodeji, Olufemi, Liasu, Ahmed A., Isamotu, Rafiu O., Gadzama, Galadima, Petros, Brittany A., Siddle, Katherine J., Schaffner, Stephen F., Akpede, George, Erameh, Cyril Oshomah, Baba, Marycelin M., Oladiji, Femi, Audu, Rosemary, Ndodo, Nnaemeka, Fowotade, Adeola, Okogbenin, Sylvanus, Okokhere, Peter O., Park, Danny J., Mcannis, Bronwyn L., Adetifa, Ifedayo M., Ihekweazu, Chikwe, Salako, Babatunde L., Tomori, Oyewale, Happi, Anise N., Folarin, Onikepe A., Andersen, Kristian G., Sabeti, Pardis C., and Happi, Christian T.
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- 2023
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4. Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions
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Parker, Edyth, Anderson, Catelyn, Zeller, Mark, Tibi, Ahmad, Havens, Jennifer L, Laroche, Geneviève, Benlarbi, Mehdi, Ariana, Ardeshir, Robles-Sikisaka, Refugio, Latif, Alaa Abdel, Watts, Alexander, Awidi, Abdalla, Jaradat, Saied A, Gangavarapu, Karthik, Ramesh, Karthik, Kurzban, Ezra, Matteson, Nathaniel L, Han, Alvin X, Hughes, Laura D, McGraw, Michelle, Spencer, Emily, Nicholson, Laura, Khan, Kamran, Suchard, Marc A, Wertheim, Joel O, Wohl, Shirlee, Côté, Marceline, Abdelnour, Amid, Andersen, Kristian G, and Abu-Dayyeh, Issa
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Life on Land ,COVID-19 ,Humans ,Middle East ,Pandemics ,SARS-CoV-2 ,Travel - Abstract
Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and intercontinental connectivity to the source-sink dynamics of SARS-CoV-2 for Jordan and the Middle East. By integrating genomic, epidemiological and travel data we show that the source of introductions into Jordan was dynamic across 2020, shifting from intercontinental seeding in the early pandemic to more regional seeding for the travel restrictions period. We show that land travel, particularly freight transport, drove introduction risk during the travel restrictions period. High regional connectivity and land travel also drove Jordan's export risk. Our findings emphasize regional connectedness and land travel as drivers of transmission in the Middle East.
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- 2022
5. Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades
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Klitting, Raphaëlle, Kafetzopoulou, Liana E, Thiery, Wim, Dudas, Gytis, Gryseels, Sophie, Kotamarthi, Anjali, Vrancken, Bram, Gangavarapu, Karthik, Momoh, Mambu, Sandi, John Demby, Goba, Augustine, Alhasan, Foday, Grant, Donald S, Okogbenin, Sylvanus, Ogbaini-Emovo, Ephraim, Garry, Robert F, Smither, Allison R, Zeller, Mark, Pauthner, Matthias G, McGraw, Michelle, Hughes, Laura D, Duraffour, Sophie, Günther, Stephan, Suchard, Marc A, Lemey, Philippe, Andersen, Kristian G, and Dellicour, Simon
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Infectious Diseases ,Emerging Infectious Diseases ,Rare Diseases ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,Life on Land ,Animals ,Humans ,Lassa Fever ,Lassa virus ,Phylogeography ,Risk Factors ,Rodentia - Abstract
Lassa fever is a severe viral hemorrhagic fever caused by a zoonotic virus that repeatedly spills over to humans from its rodent reservoirs. It is currently not known how climate and land use changes could affect the endemic area of this virus, currently limited to parts of West Africa. By exploring the environmental data associated with virus occurrence using ecological niche modelling, we show how temperature, precipitation and the presence of pastures determine ecological suitability for virus circulation. Based on projections of climate, land use, and population changes, we find that regions in Central and East Africa will likely become suitable for Lassa virus over the next decades and estimate that the total population living in ecological conditions that are suitable for Lassa virus circulation may drastically increase by 2070. By analysing geotagged viral genomes using spatially-explicit phylogeography and simulating virus dispersal, we find that in the event of Lassa virus being introduced into a new suitable region, its spread might remain spatially limited over the first decades.
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- 2022
6. Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework.
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Dellicour, Simon, Lequime, Sebastian, Vrancken, Bram, Gill, Mandev S, Bastide, Paul, Gangavarapu, Karthik, Matteson, Nathaniel L, Tan, Yi, du Plessis, Louis, Fisher, Alexander A, Nelson, Martha I, Gilbert, Marius, Suchard, Marc A, Andersen, Kristian G, Grubaugh, Nathan D, Pybus, Oliver G, and Lemey, Philippe
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Animals ,Bird Diseases ,Ecosystem ,Environment ,Genetic Variation ,Genome ,Viral ,Humans ,North America ,Phylogeny ,Phylogeography ,West Nile Fever ,West Nile virus ,Genome ,Viral - Abstract
Computational analyses of pathogen genomes are increasingly used to unravel the dispersal history and transmission dynamics of epidemics. Here, we show how to go beyond historical reconstructions and use spatially-explicit phylogeographic and phylodynamic approaches to formally test epidemiological hypotheses. We illustrate our approach by focusing on the West Nile virus (WNV) spread in North America that has substantially impacted public, veterinary, and wildlife health. We apply an analytical workflow to a comprehensive WNV genome collection to test the impact of environmental factors on the dispersal of viral lineages and on viral population genetic diversity through time. We find that WNV lineages tend to disperse faster in areas with higher temperatures and we identify temporal variation in temperature as a main predictor of viral genetic diversity through time. By contrasting inference with simulation, we find no evidence for viral lineages to preferentially circulate within the same migratory bird flyway, suggesting a substantial role for non-migratory birds or mosquito dispersal along the longitudinal gradient.
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- 2020
7. Accommodating individual travel history and unsampled diversity in Bayesian phylogeographic inference of SARS-CoV-2.
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Lemey, Philippe, Hong, Samuel L, Hill, Verity, Baele, Guy, Poletto, Chiara, Colizza, Vittoria, O'Toole, Áine, McCrone, John T, Andersen, Kristian G, Worobey, Michael, Nelson, Martha I, Rambaut, Andrew, and Suchard, Marc A
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Humans ,Pneumonia ,Viral ,Coronavirus Infections ,Bayes Theorem ,Phylogeny ,Genome ,Viral ,Travel ,Pandemics ,Phylogeography ,Betacoronavirus ,COVID-19 ,SARS-CoV-2 ,Genome ,Viral ,Pneumonia - Abstract
Spatiotemporal bias in genome sampling can severely confound discrete trait phylogeographic inference. This has impeded our ability to accurately track the spread of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, despite the availability of unprecedented numbers of SARS-CoV-2 genomes. Here, we present an approach to integrate individual travel history data in Bayesian phylogeographic inference and apply it to the early spread of SARS-CoV-2. We demonstrate that including travel history data yields i) more realistic hypotheses of virus spread and ii) higher posterior predictive accuracy compared to including only sampling location. We further explore methods to ameliorate the impact of sampling bias by augmenting the phylogeographic analysis with lineages from undersampled locations. Our reconstructions reinforce specific transmission hypotheses suggested by the inclusion of travel history data, but also suggest alternative routes of virus migration that are plausible within the epidemiological context but are not apparent with current sampling efforts.
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- 2020
8. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques
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Magnani, Diogo M., primary, Rogers, Thomas F., additional, Maness, Nicholas J., additional, Grubaugh, Nathan D., additional, Beutler, Nathan, additional, Bailey, Varian K., additional, Gonzalez-Nieto, Lucas, additional, Gutman, Martin J., additional, Pedreño-Lopez, Núria, additional, Kwal, Jaclyn M., additional, Ricciardi, Michael J., additional, Myers, Tereance A., additional, Julander, Justin G., additional, Bohm, Rudolf P., additional, Gilbert, Margaret H., additional, Schiro, Faith, additional, Aye, Pyone P., additional, Blair, Robert V., additional, Martins, Mauricio A., additional, Falkenstein, Kathrine P., additional, Kaur, Amitinder, additional, Curry, Christine L., additional, Kallas, Esper G., additional, Desrosiers, Ronald C., additional, Goldschmidt-Clermont, Pascal J., additional, Whitehead, Stephen S., additional, Andersen, Kristian G., additional, Bonaldo, Myrna C., additional, Lackner, Andrew A., additional, Panganiban, Antonito T., additional, Burton, Dennis R., additional, and Watkins, David I., additional
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- 2018
- Full Text
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9. Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
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Robinson, James E., primary, Hastie, Kathryn M., additional, Cross, Robert W., additional, Yenni, Rachael E., additional, Elliott, Deborah H., additional, Rouelle, Julie A., additional, Kannadka, Chandrika B., additional, Smira, Ashley A., additional, Garry, Courtney E., additional, Bradley, Benjamin T., additional, Yu, Haini, additional, Shaffer, Jeffrey G., additional, Boisen, Matt L., additional, Hartnett, Jessica N., additional, Zandonatti, Michelle A., additional, Rowland, Megan M., additional, Heinrich, Megan L., additional, Martínez-Sobrido, Luis, additional, Cheng, Benson, additional, de la Torre, Juan C., additional, Andersen, Kristian G., additional, Goba, Augustine, additional, Momoh, Mambu, additional, Fullah, Mohamed, additional, Gbakie, Michael, additional, Kanneh, Lansana, additional, Koroma, Veronica J., additional, Fonnie, Richard, additional, Jalloh, Simbirie C., additional, Kargbo, Brima, additional, Vandi, Mohamed A., additional, Gbetuwa, Momoh, additional, Ikponmwosa, Odia, additional, Asogun, Danny A., additional, Okokhere, Peter O., additional, Follarin, Onikepe A., additional, Schieffelin, John S., additional, Pitts, Kelly R., additional, Geisbert, Joan B., additional, Kulakoski, Peter C., additional, Wilson, Russell B., additional, Happi, Christian T., additional, Sabeti, Pardis C., additional, Gevao, Sahr M., additional, Khan, S. Humarr, additional, Grant, Donald S., additional, Geisbert, Thomas W., additional, Saphire, Erica Ollmann, additional, Branco, Luis M., additional, and Garry, Robert F., additional
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- 2016
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