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Your search keyword '"De Zio, Daniela"' showing total 5 results
Start Over Author "De Zio, Daniela" Journal nature cell biology
5 results on '"De Zio, Daniela"'

1. Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Author

Cianfanelli, Valentina, primary, Fuoco, Claudia, additional, Lorente, Mar, additional, Salazar, Maria, additional, Quondamatteo, Fabio, additional, Gherardini, Pier Federico, additional, De Zio, Daniela, additional, Nazio, Francesca, additional, Antonioli, Manuela, additional, D'Orazio, Melania, additional, Skobo, Tatjana, additional, Bordi, Matteo, additional, Rohde, Mikkel, additional, Valle, Luisa Dalla, additional, Helmer-Citterich, Manuela, additional, Gretzmeier, Christine, additional, Dengjel, Joern, additional, Fimia, Gian Maria, additional, Piacentini, Mauro, additional, Di Bartolomeo, Sabrina, additional, Velasco, Guillermo, additional, and Cecconi, Francesco, additional

Published
2015
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2. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Author

Cianfanelli, Valentina, primary, Fuoco, Claudia, additional, Lorente, Mar, additional, Salazar, Maria, additional, Quondamatteo, Fabio, additional, Gherardini, Pier Federico, additional, De Zio, Daniela, additional, Nazio, Francesca, additional, Antonioli, Manuela, additional, D’Orazio, Melania, additional, Skobo, Tatjana, additional, Bordi, Matteo, additional, Rohde, Mikkel, additional, Dalla Valle, Luisa, additional, Helmer-Citterich, Manuela, additional, Gretzmeier, Christine, additional, Dengjel, Joern, additional, Fimia, Gian Maria, additional, Piacentini, Mauro, additional, Di Bartolomeo, Sabrina, additional, Velasco, Guillermo, additional, and Cecconi, Francesco, additional

Published
2014
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3. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

Author

Cianfanelli, Valentina, Fuoco, Claudia, Lorente, Mar, Salazar, Maria, Quondamatteo, Fabio, Gherardini, Pier Federico, De Zio, Daniela, Nazio, Francesca, Antonioli, Manuela, D'Orazio, Melania, Skobo, Tatjana, Bordi, Matteo, Rohde, Mikkel, Dalla Valle, Luisa, Helmer-Citterich, Manuela, Gretzmeier, Christine, Dengjel, Joern, Fimia, Gian Maria, Piacentini, Mauro, and Di Bartolomeo, Sabrina

Subjects
SCAFFOLD proteins, CELL metabolism, AUTOPHAGY, CELL proliferation, NEOPLASTIC cell transformation, DEPHOSPHORYLATION
Abstract

Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the scaffold protein AMBRA1, a member of the autophagy signalling network and a downstream target of mTOR, regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc. We found that AMBRA1 favours the interaction between c-Myc and its phosphatase PP2A and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate. As expected, such a de-regulation of c-Myc correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene. [ABSTRACT FROM AUTHOR]

Published
2015
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4. Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

Author

Cianfanelli, Valentina, Fuoco, Claudia, Lorente, Mar, Salazar, Maria, Quondamatteo, Fabio, Gherardini, Pier Federico, De Zio, Daniela, Nazio, Francesca, Antonioli, Manuela, D'Orazio, Melania, Skobo, Tatjana, Bordi, Matteo, Rohde, Mikkel, Valle, Luisa Dalla, Helmer-Citterich, Manuela, Gretzmeier, Christine, Dengjel, Joern, Fimia, Gian Maria, Piacentini, Mauro, and Di Bartolomeo, Sabrina

Subjects
WESTERN immunoblotting, CELL proliferation, NEOPLASTIC cell transformation
Abstract

A correction to the article "AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation" that was published in the 2015 issue is presented.

Published
2015
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5. AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation

Author

Cclaudia Fuoco, Daniela De Zio, Mikkel Rohde, María Salazar, Luisa Dalla Valle, Francesca Nazio, Valentina Cianfanelli, Mar Lorente, Matteo Bordi, Sabrina Di Bartolomeo, Mauro Piacentini, Manuela Antonioli, Fabio Quondamatteo, Francesco Cecconi, Guillermo Velasco, Gian Maria Fimia, Manuela Helmer-Citterich, Pier Federico Gherardini, Joern Dengjel, Christine Gretzmeier, Tatjana Skobo, Melania D'Orazio, Cianfanelli, Valentina, Fuoco, Claudia, Lorente, Mar, Salazar, Maria, Quondamatteo, Fabio, Gherardini, Pier Federico, De Zio, Daniela, Nazio, Francesca, Antonioli, Manuela, D'Orazio, Melania, Skobo, Tatjana, Bordi, Matteo, Rohde, Mikkel, Dalla Valle, Luisa, Helmer Citterich, Manuela, Gretzmeier, Christine, Dengjel, Joern, Fimia, Gian Maria, Piacentini, Mauro, Di Bartolomeo, Sabrina, Velasco, Guillermo, and Cecconi, Francesco

Subjects
Male, Scaffold protein, Cell division, autophagy, proliferation, Ambra1, Haploinsufficiency, Mice, cell metabolism, Genes, Tumor Suppressor, Protein Phosphatase 2, Phosphorylation, RNA, Small Interfering, phosphatases, Zebrafish, mammalian autophagy, Settore BIO/11, TOR Serine-Threonine Kinases, inhibits autophagy, Cell biology, Cell Transformation, Neoplastic, regulates autophagy, mTOR, Female, RNA Interference, cell cycle, Cell Division, Settore BIO/06, protein phosphatase 2a, growth, Mice, Transgenic, Biology, Article, Proto-Oncogene Proteins c-myc, Cell Line, Tumor, Autophagy, Animals, Humans, cancer, Protein kinase A, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, Cell growth, RPTOR, association, Cell Biology, Protein phosphatase 2, Mice, Inbred C57BL, HEK293 Cells, human malignancies, pp2a, HeLa Cells
Abstract

Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the scaffold protein AMBRA1, a member of the autophagy signalling network and a downstream target of mTOR, regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc. We found that AMBRA1 favours the interaction between c-Myc and its phosphatase PP2A and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate. As expected, such a de-regulation of c-Myc correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene.

Published
2014

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