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1. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.

Author

Lu, Pei-Jung, Wulf, Gerburg, Zhen Zhou, Xiao, Davies, Peter, and Ping Lu, Kun

Subjects
GENETICS of Alzheimer's disease, ISOMERASES, PROTEINS, NERVE fibers, PHYSIOLOGY
Abstract

Presents research which studied the role of the protein tau in Alzheimer's disease. The neurofibrillary tangle of paired helical filaments (PHFs) composed of tau; Hyperphosphorylation and phosphorylation of tau; Binding site for the WW domain of the prolyl isomerase Pin1; Effects of Pin1 on mitosis; Depletion of soluble Pin1 in Alzheimer's patients, and its effects; Value of research.

Published
1999
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