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Author(s): Praneeth Namburi [1, 2]; Anna Beyeler [1]; Suzuko Yorozu [3]; Gwendolyn G. Calhoon [1]; Sarah A. Halbert [1, 4]; Romy Wichmann [1]; Stephanie S. Holden [1, 5]; Kim L. [...]

Viral infection during pregnancy is correlated with increased frequency of neurodevelopmental disorders, and this is studied in mice prenatally subjected to maternal immune activation (MIA). We previously showed that maternal T helper 17 cells promote the development of cortical and behavioural abnormalities in MIA-affected offspring. Here we show that cortical abnormalities are preferentially localized to a region encompassing the dysgranular zone of the primary somatosensory cortex (S1DZ). Moreover, activation of pyramidal neurons in this cortical region was sufficient to induce MIA-associated behavioural phenotypes in wild-type animals, whereas reduction in neural activity rescued the behavioural abnormalities in MIA-affected offspring. Sociability and repetitive behavioural phenotypes could be selectively modulated according to the efferent targets of S1DZ. Our work identifies a cortical region primarily, if not exclusively, centred on the S1DZ as the major node of a neural network that mediates behavioural abnormalities observed in offspring exposed to maternal inflammation., Author(s): Yeong Shin Yim [1, 2]; Ashley Park [1, 2]; Janet Berrios [1, 2]; Mathieu Lafourcade [1, 2]; Leila M. Pascual [1, 2]; Natalie Soares [1, 2]; Joo Yeon Kim [...]

Author(s): Kai Liu [1]; Juhyun Kim [1]; Dong Won Kim [1]; Yi Stephanie Zhang [1]; Hechen Bao [2]; Myrto Denaxa [3]; Szu-Aun Lim [2]; Eileen Kim [4]; Chang Liu [1]; [...]