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SEVERAL reports have appeared recently regarding the effect of various halogenatedpyrimidines on herpes simplex virus1–3. 5-Iodo-2′-deoxyuridine (IUDR) and 5-fluoro-2′-deoxyuridine inhibit the herpes simplex virus growth, both in vitro and in vivo. These halogenated pyrimidines inhibit the biosynthesis of deoxyribonucleic acid by competing with thymidine in the synthesis of DNA-thymidine in mouse Ehrlich ascite cells.

Guanidine Conditioned Infectivity of Ribonucleic Acid extracted from a Strain of Guanidine-dependent Polio-l-Virus

I HAVE previously shown that a guanylhydrazone derivative of a known steroid molecule is a powerful antimitotic agent1. This compound, the structure of which is shown in Fig. 1, is 3-guanyl-hydrazone-androstan-17-ol; it is listed by the Italian pharmaceutical house Vister as 2052 V (Fig. 1).