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1. Structural basis of potent Zika-dengue virus antibody cross-neutralization

Author

Barba-Spaeth, Giovanna, Dejnirattisai, Wanwisa, Rouvinski, Alexander, Vaney, Marie-Christine, Medits, Iris, Sharma, Arvind, Simon-Loriere, Etienne, Sakuntabhai, Anavaj, Cao-Lormeau, Van-Mai, Haouz, Ahmed, England, Patrick, Stiasny, Karin, Mongkolsapaya, Juthathip, Heinz, Franz X., Screaton, Gavin R., and Rey, Felix A.

Subjects
Guillain-Barre syndrome -- Research -- Health aspects, Viral antibodies -- Research -- Health aspects, Antibodies -- Research -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue virus infections., Zika virus (ZIKV) is an arthropod-borne enveloped virus belonging to the Flavivirus genus in the family Flaviviridae, which also includes the human pathogenic yellow fever, dengue, West Nile and tick-borne [...]

Published
2016
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2. A global network for investigating the genomic epidemiology of malaria

Author

Achidi, Eric Akum, Agbenyega, Tsiri, Allen, Stephen, Amodu, Olukemi, Bojang, Kalifa, Conway, David, Corran, Patrick, Deloukas, Panos, Djimde, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Drakeley, Chris, Duffy, Patrick, Dunstan, Sarah, Evans, Jennifer, Farrar, Jeremy, Fernando, Deepika, Hien, Tran Tinh, Horstmann, Rolf, Ibrahim, Muntaser, Karunaweera, Nadira, Kokwaro, Gilbert, Koram, Kojo, Kwiatkowski, Dominic, Lemnge, Martha, Makani, Julie, Marsh, Kevin, Michon, Pascal, Modiano, David, Molyneux, Malcolm E., Mueller, Ivo, Mutabingwa, Theonest, Peshu, Norbert, Plowe, Chris, Puijalon, Odile, Ragoussis, Jiannis, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Rogers, Jane, Sakuntabhai, Anavaj, Singhasivanon, Pratap, Sirima, Sodiomon, Sirugo, Giorgio, Tall, Adama, Taylor, Terrie, Thera, Mahamadou, Troye-Blomberg, Marita, Williams, Tom, Wilson, Michael, Amenga-Etego, Lucas, Apinjoh, Tobias O., Bougouma, Edith, Dewasurendra, Rajika, Diakite, Mahamadou, Enimil, Anthony, Hussein, Ayman, Ishengoma, Deus, Jallow, Muminatou, Lin, Enmoore, Ly, Alioune, Mangano, Valentina D., Manjurano, Alphaxard, Manning, Laurens, Ndila, Carolyne M., Nyirongo, Vysaul, Oluoch, Tom, Quyen, Nguyen T. N., Suriyaphol, Prapat, Toure, Ousman, Kwiatkowski, Dominic, Alcock, Daniel, Auburn, Sarah, Barnwell, David, Bull, Susan, Campino, Susana, deVries, Jantina, Elzein, Abier, Evans, Julie, Fitzpatrick, Kathryn, Ghansah, Anita, Green, Angie, Hart, Lee, Hilton, Eliza, Hubbart, Christina, Hughes, Catherine, Jeffreys, Anna E., Kivinen, Katja, MacInnis, Bronwyn, Manske, Magnus, Maslen, Gareth, McCreight, Marilyn, Mendy, Alieu, Moyes, Catherine, Nyika, Aceme, Potter, Claire, Risley, Paul, Rowlands, Kate, SanJoaquin, Miguel, Small, Kerrin, Somaskantharajah, Elilan, Stevens, Marryat, Teo, YikYing, Watson, Renee, Carucci, Dan, Cook, Katharine, Doyle, Alan, Duombo, Ogobara, Gottlieb, Michael, Kwiatkowski, Dominic, Rockett, Kirk A., Vanderwal, Aaron, Clark, Taane, Parker, Michael, and Wrigley, Rebecca

Published
2008
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3. Erratum: Structural basis of potent Zikadengue virus antibody cross-neutralization

Author

Barba-Spaeth, Giovanna, Dejnirattisai, Wanwisa, Rouvinski, Alexander, Vaney, Marie-Christine, Medits, Iris, Sharma, Arvind, Simon-Lorire, Etienne, Sakuntabhai, Anavaj, Cao-Lormeau, Van-Mai, Haouz, Ahmed, England, Patrick, Stiasny, Karin, Mongkolsapaya, Juthathip, Heinz, Franz X., Screaton, Gavin R., and Rey, Flix A.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Giovanna Barba-Spaeth; Wanwisa Dejnirattisai; Alexander Rouvinski; Marie-Christine Vaney; Iris Medits; Arvind Sharma; Etienne Simon-Lorire; Anavaj Sakuntabhai; Van-Mai Cao-Lormeau; Ahmed Haouz; Patrick England; Karin Stiasny; Juthathip Mongkolsapaya; Franz X. Heinz; [...]

Published
2016
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4. Structural basis of potent Zika-dengue virus antibody cross-neutralization

Author

Franz X. Heinz, Juthathip Mongkolsapaya, Ahmed Haouz, Arvind Sharma, Patrick England, Van-Mai Cao-Lormeau, Wanwisa Dejnirattisai, Félix A. Rey, Anavaj Sakuntabhai, Iris Medits, Etienne Simon-Loriere, Gavin R. Screaton, Karin Stiasny, Alexander Rouvinski, Giovanna Barba-Spaeth, Marie Christine Vaney, Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Division of Immunology and Inflammation, Department of Medicine, Imperial College London-Hammersmith Hospital Campus, Medizinische Universität Wien = Medical University of Vienna, Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Emerging Infectious Diseases, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Cristallographie (Plateforme) - Crystallography (Platform), Biophysique des Macromolécules et de leurs Interactions, Siriraj Hospital, Mahidol University, Mahidol University [Bangkok], We acknowledge support from the European Commission FP7 Programme for the DENFREE project under Grant Agreement number 282 378FP7 (F.A.R., J.M., G.R.S. and A.Sa.), the 'Integrative Biology of Emerging Infectious Diseases' Labex (Laboratoire d’Excellence) grant number ANR-10-LABX-62-IBEID (French Government’s 'Investissements d’Avenir' program ) (F.A.R.), the transnational ANR/FWF grant FlaviStem/I1378 (F.A.R. and K.S.), the Medical Research Council, UK (J.M.), the National Institute for Health Research Biomedical Research Centre, Funding Scheme, UK (G.R.S.), and the NEUTRAVIR grant from Région ile-de-France (DIM-Maladies Infectieuses) (P.E., A.H. and F.A.R., ANR-13-ISV8-0002,flavistem,La protéine E des flavivirus : interactions et fusion membranaire(2013), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 282378,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,DENFREE(2012), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Medical Research Council (MRC), Wellcome Trust, and Commission of the European Communities

Subjects
DYNAMICS, 0301 basic medicine, Models, Molecular, viruses, [SDV]Life Sciences [q-bio], Antigen-Antibody Complex, Dengue virus, medicine.disease_cause, Crystallography, X-Ray, Epitope, Zika virus, Dengue fever, Dengue, Epitopes, 0302 clinical medicine, Viral Envelope Proteins, INFECTION, Virus maturation, IN-VIVO, FLAVIVIRUSES, Phylogeny, Multidisciplinary, Zika Virus Infection, Antibodies, Monoclonal, REACTIVE ANTIBODIES, FUSION-LOOP, 3. Good health, Multidisciplinary Sciences, Flavivirus, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Science & Technology - Other Topics, Brazil, General Science & Technology, Dengue Vaccines, Biology, Cross Reactions, MATURATION, Microbiology, 03 medical and health sciences, ENHANCEMENT, medicine, Humans, Antibody-dependent enhancement, Dengue vaccine, Science & Technology, RECEPTOR, RECOGNITION, Viral Vaccines, Zika Virus, Dengue Virus, biology.organism_classification, medicine.disease, Virology, Antibodies, Neutralizing, 030104 developmental biology, 030217 neurology & neurosurgery
Abstract

International audience; Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue virus infections.

Published
2016

5. Erratum: Structural basis of potent Zika–dengue virus antibody cross-neutralization

Author

Barba-Spaeth, Giovanna, primary, Dejnirattisai, Wanwisa, additional, Rouvinski, Alexander, additional, Vaney, Marie-Christine, additional, Medits, Iris, additional, Sharma, Arvind, additional, Simon-Lorière, Etienne, additional, Sakuntabhai, Anavaj, additional, Cao-Lormeau, Van-Mai, additional, Haouz, Ahmed, additional, England, Patrick, additional, Stiasny, Karin, additional, Mongkolsapaya, Juthathip, additional, Heinz, Franz X., additional, Screaton, Gavin R., additional, and Rey, Félix A., additional

Published
2016
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6. Erratum: Structural basis of potent Zika–dengue virus antibody cross-neutralization

Author

Giovanna Barba-Spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie-Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simon-Lorière, Anavaj Sakuntabhai, Van-Mai Cao-Lormeau, Ahmed Haouz, Patrick England, Karin Stiasny, Juthathip Mongkolsapaya, Franz X. Heinz, Gavin R. Screaton, and Félix A. Rey

Subjects
Multidisciplinary
Published
2016

7. A global network for investigating the genomic epidemiology of malaria

Author

Julie Makani, Kathryn Fitzpatrick, Ogobara K. Duombo, Jennifer Evans, Claire Potter, Giorgio Sirugo, Enmoore Lin, Christina Hubbart, Abier Elzein, Martha M. Lemnge, Anthony Enimil, Alioune Ly, Olukemi K. Amodu, Valentina D. Mangano, Angie Green, Alphaxard Manjurano, Dominic P. Kwiatkowski, Ivo Mueller, David Barnwell, Anna E. Jeffreys, Marryat Stevens, Thomas N. Williams, David Modiano, Sarah J. Dunstan, Taane G. Clark, Susana Campino, Tobias O. Apinjoh, Tran Tinh Hien, Sodiomon B. Sirima, David J. Conway, Terrie Taylor, Anavaj Sakuntabhai, L. Amenga-Etego, Catherine L. Moyes, Nguyen Ngoc Quyen, Laurens Manning, Mahamadou Diakite, Katharine Cook, Patrick H. Corran, Jeremy Farrar, Nadira D. Karunaweera, Kevin Marsh, Ogobara K. Doumbo, Catherine Hughes, Eric A. Achidi, Kirk A. Rockett, Chris Drakeley, Tsiri Agbenyega, Panos Deloukas, Mahamadou A. Thera, Kalifa Bojang, Julie Evans, Aaron Vanderwal, Christopher V. Plowe, Pascal Michon, Adama Tall, Aceme Nyika, Michael Gottlieb, Renee Watson, Gilbert Kokwaro, Jiannis Ragoussis, Eleanor M. Riley, Stephen Allen, Katja Kivinen, Muntaser E. Ibrahim, Bronwyn MacInnis, Vysaul Nyirongo, Elilan Somaskantharajah, Ayman S. Hussein, Alan Doyle, Carolyne M. Ndila, Michael T. Wilson, Muminatou Jallow, Jane Rogers, Abdoulaye Djimde, Deepika Fernando, Jantina DeVries, Patrick E. Duffy, Odile Puijalon, Yik Ying Teo, Kate Rowlands, Michael W. Parker, Deus S. Ishengoma, Marilyn McCreight, Edith C. Bougouma, Tom Oluoch, Rebecca Wrigley, Kerrin S. Small, Hugh Reyburn, Gareth Maslen, Malcolm E. Molyneux, Sarah Auburn, Eliza Hilton, Lee Hart, Pratap Singhasivanon, Alieu Mendy, Miguel A. Sanjoaquin, Magnus Manske, Anita Ghansah, Rajika L. Dewasurendra, Amagana Dolo, Dan Carucci, Theonest K. Mutabingwa, Prapat Suriyaphol, Marita Troye-Blomberg, Paul Risley, Susan Bull, Rolf D. Horstmann, Daniel Alcock, Ousman Toure, Kojo Koram, John C. Reeder, and Norbert Peshu

Subjects
Burden of disease, Economic growth, medicine.medical_specialty, Plasmodium, Population, Developing country, Global Health, Polymorphism, Single Nucleotide, Article, Political science, Epidemiology, Global network, Anopheles, Global health, medicine, Animals, Humans, education, education.field_of_study, Multidisciplinary, biology, business.industry, Genome, Human, biology.organism_classification, medicine.disease, Immunity, Innate, Biotechnology, Malaria, Epidemiologic Research Design, business, Genome-Wide Association Study
Abstract

Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease is greatest. The Malaria Genomic Epidemiology Network (MalariaGEN) is now working to overcome these obstacles, using a consortial approach that brings together researchers from 21 countries. © 2008 Macmillan Publishers Limited. All rights reserved.

Published
2008

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