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An unusual form of cell death called ferroptosis can sweep over embryonic tissues in a wave-like manner to ensure proper muscle development — evidence that ferroptosis has a role in normal physiology.Iron-dependent cell death sweeps across tissue to shape embryonic muscle. [ABSTRACT FROM AUTHOR]

Insect respiration is commonly thought to rely solely on direct gas exchange through air-filled tracheal tubes. The discovery of oxygen-transporting blood cells in fly larvae reveals a previously unknown way to oxygenate fly tissues.Blood cells can transport oxygen to the tissues of fruit flies. [ABSTRACT FROM AUTHOR]

Decades of evidence shows that exercise leads to healthier, longer lives. Researchers are just starting to work out what it does to cells to reap this reward. [ABSTRACT FROM AUTHOR]

Nature speaks to the world’s first disabled astronaut about his hopes for the future of space exploration. [ABSTRACT FROM AUTHOR]

An impressive combination of computational modelling and experimental techniques in live zebrafish embryos reveals how the heart initiates its organized and rhythmic beating.How calcium waves organize and propagate across the developing heart. [ABSTRACT FROM AUTHOR]

The tissue developed into functioning kidneys and produced urine. [ABSTRACT FROM AUTHOR]

The operation’s early success has made researchers hopeful that clinical trials for xenotransplanted organs will start soon.The early success of the operation has made researchers hopeful that clinical trials for xenotransplanted organs will start soon. [ABSTRACT FROM AUTHOR]

Letter to the Editor [ABSTRACT FROM AUTHOR]

Pig organs could provide temporary detox for people whose livers need time to recover or who are awaiting human donors. [ABSTRACT FROM AUTHOR]

A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection. Microscopy reveals how haematopoiesis is organized across the skeleton. [ABSTRACT FROM AUTHOR]

Active neurons can stimulate the clearance of their own metabolic waste by driving changes to ion gradients in the surrounding fluid and by promoting the pulsation of nearby blood vessels.Neurons stimulate the brain's waste disposal system. [ABSTRACT FROM AUTHOR]

The view of biology often presented to the public is oversimplified and out of date. Scientists must set the record straight, argues a new book. [ABSTRACT FROM AUTHOR]

Maternal sensitivity to a hormone produced by the fetus might underlie the risk of severe nausea and vomiting in human pregnancy — a finding that could open up strategies for the treatment of this debilitating condition. Sensitivity to GDF15 hormone could be responsible for pregnancy nausea. [ABSTRACT FROM AUTHOR]

A suppressive type of immune cell called a regulatory T cell has a key role in helping muscles to adapt to exercise — guarding muscle mitochondrial organelles against damage mediated by proinflammatory factors generated during physical activity. Regulatory T cells protect mitochondria from damage caused by interferon. [ABSTRACT FROM AUTHOR]

Letter to the Editor [ABSTRACT FROM AUTHOR]

The model organism Caenorhabditis elegans is quick to forget a notable odour — unless it is chilled or given lithium. [ABSTRACT FROM AUTHOR]

This year, surgeons transplanted the first pig organs into human recipients. Researchers are keen to launch more human trials. [ABSTRACT FROM AUTHOR]

Katalin Karikó and Drew Weissman laid the groundwork for immunizations that were rolled out during the pandemic at record-breaking speed. [ABSTRACT FROM AUTHOR]

The female perspective is often missed in evolutionary tales, but it is at the centre of what makes us human. [ABSTRACT FROM AUTHOR]

The role of transcription in the development of electrical properties of neuronal membranes has been largely unexplored. To study the molecular events which result in the expression of these properties it is useful to describe the timing of the underlying RNA synthetic events. For example, the timing of the transcription involved in denervation-induced action potentials in frog slow muscle fibres and brain extract-induced sodium channels in chick muscle cells has been investigated. Previous studies of Xenopus laevis spinal neurones have established that the timing of the development of the neuronal action potential ionic dependence in dissociated cell cultures parallels that seen in vivo. This culture system, therefore, allows the determination of transcription-dependent periods necessary for the development of membrane properties known to have in vivo relevance. In the study described here, actinomycin D was used to examine the timing of the RNA synthetic events necessary for (1) neurite outgrowth and (2) development of the ionic dependence of the action potential. I report that inhibition of transcription at an early stage specifically blocks the appearance of the mature sodium-dependent action potential without affecting either neurite outgrowth or the development of delayed rectification.

Sex has long been used to divide sporting competitions in the name of fairness, but are the current rules and enforcement practices fit for purpose? [ABSTRACT FROM AUTHOR]

Mice that work out regularly have higher levels of a molecule that promotes muscle regeneration than sedentary mice do. [ABSTRACT FROM AUTHOR]

The production of blood cells, including some immune cells, relies heavily on the bone-marrow microenvironment. Cardiovascular diseases are now found to corrupt this niche, leading to imbalances in blood-cell production.Imbalances in blood-cell production could affect disease outcome. [ABSTRACT FROM AUTHOR]

Variants of the melanocortin 3 receptor are associated with delayed puberty and reduced growth, suggesting that this receptor might integrate signals of metabolic status that affect body growth and sexual maturation. Receptor variants associated with delayed sexual maturation. [ABSTRACT FROM AUTHOR]

In mice, the ovarian hormone oestradiol sensitizes neurons in a brain region called the hypothalamus to a melanocortin hormone that signals an energy surplus. Their dual activation increases physical activity.An oestrogen sensitizes certain neurons to signals of energy surplus. [ABSTRACT FROM AUTHOR]

Release of opioid peptide in the brain leads food-deprived mice to eat more sugar than do mice that are well fed. This opioid signalling mechanism fine-tunes the reward value of food according to the animal's state. The reward value of food is tuned according to an animal's state. [ABSTRACT FROM AUTHOR]

The observation that melanocyte stem cells migrate up and down the hair follicle, differentiating into melanocytes and then returning to a stem-cell identity, calls into question long-held assumptions about adult stem cells. Melanocyte stem cells migrate up and down the hair follicle. [ABSTRACT FROM AUTHOR]

Of hearts, and myriad other ways natural selection has hit on to sustain multicellular life. [ABSTRACT FROM AUTHOR]

Some studies suggest that the community of microorganisms that live in the gut are associated with athleticism. [ABSTRACT FROM AUTHOR]

To strike a ball moving at lightning speeds in baseball, tennis and cricket, athletes and coaches are increasingly embracing training techniques involving virtual reality. [ABSTRACT FROM AUTHOR]

The muscles of elite endurance athletes boast high numbers of extra-efficient mitochondria. Unlocking the secrets of these cellular components could yield gains for future Olympians. [ABSTRACT FROM AUTHOR]

Early detection and prompt treatment could prevent long-term health effects of acute kidney injury, a condition that commonly arises while people are in hospital. [ABSTRACT FROM AUTHOR]

During periods of anxiety, the brain affects the heart, but does a racing heart also talk to the brain to cause anxiety-related behaviour? Use of a light-stimulated pacemaker in mice shows that it does, and pinpoints a brain region involved. Tachycardia promotes anxiety-related bahviours in mice. [ABSTRACT FROM AUTHOR]

Impaired sensory-nerve function is a common complication of diabetes. Evidence in mice indicates that deficiency of the amino acid serine causes these complications — and suggests that supplements could help to treat them.Serine deficiency linked to diabetic polyneuropathy in mice. [ABSTRACT FROM AUTHOR]

Organ mapping studies show how kidney cells become diseased, and how cells from a fetus invade and remodel blood vessels in the lining of the uterus. [ABSTRACT FROM AUTHOR]

During evolution, key physiological changes enabled vertebrates to achieve a more active lifestyle. A comparison between living animals challenges current ideas on the timing of one such change in our ancestors. An early role for ion exchange as gills evolved. [ABSTRACT FROM AUTHOR]

Survey of nearly 13,000 Icelanders pinpoints for the first time a genetic variant that shapes whether a person’s voice sounds high. [ABSTRACT FROM AUTHOR]