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4. Cooperative tandem binding of met repressor of Escherichia coli.

Author

Phillips SE, Manfield I, Parsons I, Davidson BE, Rafferty JB, Somers WS, Margarita D, Cohen GN, Saint-Girons I, and Stockley PG

Subjects
Apoproteins biosynthesis, Bacterial Proteins metabolism, Base Sequence, DNA, Bacterial metabolism, Genes, Bacterial, Models, Molecular, Molecular Sequence Data, Operator Regions, Genetic, Regulatory Sequences, Nucleic Acid, Repetitive Sequences, Nucleic Acid, Repressor Proteins biosynthesis, Tryptophan metabolism, Apoproteins metabolism, Escherichia coli metabolism, Escherichia coli Proteins, Repressor Proteins metabolism, Transcription Factors metabolism
Abstract

We present biochemical and genetic data to support the hypothesis that the Escherichia coli met repressor, MetJ, binds to synthetic and natural operator sequences in tandem arrays such that repression depends not only on the affinity of the DNA-protein interaction, but also on protein-protein contacts along the tandem array. This represents a novel form of regulatory switch. Furthermore, there seems to be homology between the organization of the met and trp operators.

Published
1989
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