1. Inhibiting Effect of 2 : 4-Dinitrophenol on Calciferol-induced Metastatic Calcification in the Rat
- Author
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M. Hathorn, Theodore Gillman, and R. A. Grant
- Subjects
medicine.medical_specialty ,chemistry.chemical_element ,Ascorbic Acid ,Calcium ,2,4-Dinitrophenol ,Nitrophenols ,chemistry.chemical_compound ,Calcification, Physiologic ,Blood serum ,Oral administration ,medicine.artery ,Internal medicine ,medicine ,Animals ,Aorta ,Multidisciplinary ,Metastatic calcification ,Stomach ,Vitamins ,medicine.disease ,Rats ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Ergocalciferols ,cardiovascular system ,Dinitrophenols ,Calcification - Abstract
PREVIOUS investigations by Trout1 and by us2 indicate clearly that the deposition of mineral in the aortae of calciferol-intoxicated rats continued long after cessation of administration of this compound and after the blood calcium-level had returned to normal. It appears that, once initiated, this process follows an irreversible course, at least in the aorta, since even 160 days after the initial insult there was no evidence of a reduction in the mineral content of the aorta. Attempts to inhibit calciferol-induced calcification of the aorta by the simultaneous administration of papain (which reduces the mucopolysaccharide content of the aorta) were unsuccessful3.
- Published
- 1961
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