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As part of an extensive series of tests for carcinogenic activity a number of naphthalene and biphenyl derivatives of potential or actual commercial use were examined. The practicability of standardizing the methodology of large scale quantitative bioassay of many different compounds was also investigated.

PROPYLENE imine is an important chemical intermediate with a variety of applications in the production of polymers, coatings, adhesives, textiles and paper finishes. Likewise, propane sultone has many potential uses in the detergent, textile, rubber, pharmaceutical and agricultural chemical industries. Their chemical reactivity suggests that these compounds may have deleterious effects in living systems. Ethylene imine, closely related to the higher homologue, propylene imine, is known to have carcinogenic, mutagenic and teratogenic activity1–3. A preliminary report dealing with the carcinogenicity of propane sultone has appeared4.

THE frequency of hepatocellular carcinoma is higher in parts of tropical Africa than in certain Western countries1. Elevated levels of serum α-foetoprotein (a foetal globulin) were detected in as many as 80% of the African cases but this was much less frequent in Western patients1–7. This difference may be related to the etiology of the disease.

Rapid Liver Tumour Induction by Concerted Action of N-Hydroxy-2-acetamidofluorene and Hormonal Stimulation