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Your search keyword '"Gaur, Amitabh"' showing total 2 results
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2 results on '"Gaur, Amitabh"'

1. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

Author

Brocke, Stefan, Gijbels, Koenraad, Allegretta, Mark, Ferber, Iris, Piercy, Christopher, Blankenstein, Thomas, Martin, Roland, Utz, Ursula, Karin, Nathan, Mitchell, Dennis, Waisman, Ari, Gaur, Amitabh, Conlon, Paul, Ling, Nicholas, Fairchild, Paul J., Wraith, David C., O'Garra, Anne, Fathman, C. Garrison, Steinman, Lawrence, and Veromaa, Timo

Subjects
Encephalomyelitis -- Care and treatment, Myelin proteins -- Health aspects, T cells -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Various types of T cells with heterogeneous receptors are found in the inflammatory infiltrate in the central nervous system after experimental encephalomyelitis is induced with a T-cell clone L10C1. This clone responds to the myelin basic protein epitope p87-99. It is shown that in vivo tolerization of L10C1 with an analogue of p87-99 reverses established paralysis, reduces inflammatory infiltrates and eliminates the heterogeneous T-cell infiltrate from the brain..

Published
1996

2. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

Author

Brocke, Stefan, Gaur, Amitabh, Piercy, Christopher, Gautam, Anand, Gijbels, Koenraad, Fathman, C. Garrison, and Steinman, Lawrence

Subjects
Autoimmune diseases -- Research, Encephalomyelitis -- Research, Antigens -- Research, Bacteria -- Research, Sclerosis -- Research, Lymphocytes -- Histology, Bacteria, Pathogenic -- Research, Staphylococcus -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Experimental autoimmune encephalomylelitis is a model that can adequately explain the role of infection in causing various autoimmune diseases. The amino-terminal epitope Ac1-11 of myelin basic protein in some species of mice is engaged by the T lymphocytes that express the V beta 8 T-cell receptors. The V beta 8 expressing expressing T cells are activated by the bacterial superantigen staphylococcal enteroxin B (SEB). The mechanism causing the SEB induced exacerbation of disease is critically induced by the tumor neurosis factor.

Published
1993

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