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8 results on '"Flint Jonathan"'

1. Sparse whole-genome sequencing identifies two loci for major depressive disorder

Author

Cai, Na, Bigdeli, Tim B., Kretzschmar, Warren, Li, Yihan, Liang, Jieqin, Song, Li, Hu, Jingchu, Li, Qibin, Jin, Wei, Hu, Zhenfei, Wang, Guangbiao, Wang, Linmao, Qian, Puyi, Liu, Yuan, Jiang, Tao, Lu, Yao, Zhang, Xiuqing, Yin, Ye, Li, Yingrui, Xu, Xun, Gao, Jingfang, Reimers, Mark, Webb, Todd, Riley, Brien, Bacanu, Silviu, Peterson, Roseann E., Chen, Yiping, Zhong, Hui, Liu, Zhengrong, Wang, Gang, Sun, Jing, Sang, Hong, Jiang, Guoqing, Zhou, Xiaoyan, Li, Yi, Zhang, Wei, Wang, Xueyi, Fang, Xiang, Pan, Runde, Miao, Guodong, Zhang, Qiwen, Hu, Jian, Yu, Fengyu, Du, Bo, Sang, Wenhua, Li, Keqing, Chen, Guibing, Cai, Min, Yang, Lijun, Yang, Donglin, Ha, Baowei, Hong, Xiaohong, Deng, Hong, Li, Gongying, Li, Kan, Song, Yan, Gao, Shugui, Zhang, Jinbei, Gan, Zhaoyu, Meng, Huaqing, Pan, Jiyang, Gao, Chengge, Zhang, Kerang, Sun, Ning, Li, Youhui, Niu, Qihui, Zhang, Yutang, Liu, Tieqiao, Hu, Chunmei, Zhang, Zhen, Lv, Luxian, Dong, Jicheng, Wang, Xiaoping, Tao, Ming, Wang, Xumei, Xia, Jing, Rong, Han, He, Qiang, Liu, Tiebang, Huang, Guoping, Mei, Qiyi, Shen, Zhenming, Liu, Ying, Shen, Jianhua, Tian, Tian, Liu, Xiaojuan, Wu, Wenyuan, Gu, Danhua, Fu, Guangyi, Shi, Jianguo, Chen, Yunchun, Gan, Xiangchao, Liu, Lanfen, Wang, Lina, Yang, Fuzhong, Cong, Enzhao, Marchini, Jonathan, Yang, Huanming, Wang, Jian, Shi, Shenxun, Mott, Richard, Xu, Qi, Wang, Jun, Kendler, Kenneth S., and Flint, Jonathan

Published
2015
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2. Sequence-based characterization of structural variation in the mouse genome

Author

Yalcin, Binnaz, Wong, Kim, Agam, Avigail, Goodson, Martin, Keane, Thomas M., Gan, Xiangchao, Nellaker, Christoffer, Goodstadt, Leo, Nicod, Jerome, Bhomra, Amarjit, Hernandez-Pliego, Polinka, Whitley, Helen, Cleak, James, Dutton, Rebekah, Janowitz, Deborah, Mott, Richard, Adams, David J., and Flint, Jonathan

Subjects
Nucleotide sequence -- Structure, Genomes -- Structure -- Properties, Mice -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Structural variation is widespread in mammalian genomes (1,2) and is an important cause of disease (3), but just how abundant and important structural variants (SVs) are in shaping phenotypic variation remains unclear (4,5). Without knowing how many SVs there are, and how they arise, it is difficult to discover what they do. Combining experimental with automated analyses, we identified 711,920 SVs at 281,243 sites in the genomes of thirteen classical and four wild-derived inbred mouse strains. The majority of SVs are less than 1 kilobase in size and 98% are deletions or insertions. The breakpoints of 160,000 SVs were mapped to base pair resolution, allowing us to infer that insertion of retrotransposons causes more than half of SVs. Yet, despite their prevalence, SVs are less likely than other sequence variants to cause gene expression or quantitative phenotypic variation. We identified 24 SVs that disrupt coding exons, acting as rare variants of large effect on gene function. One-third of the genes so affected have immunological functions., The pre-eminent organism for modelling the relationship between phenotype and genotype, including SVs, is the mouse, but our catalogue of SVs in this animal is incomplete (6) and most of [...]

Published
2011
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4. Applying mouse complex-trait resources to behavioural genetics

Author

Flint, Jonathan and Mott, Richard

Subjects
Gene mutations -- Research, Behavior genetics -- Research, Genetic variation -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation, Research
Abstract

Studies of the genetic basis of behaviour in mice are at a turning point. Soon, new resources will enable the behavioural function of all genes to be tested and the networks of genes, messenger RNAs and proteins involved in a particular behaviour to be identified. Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches., In the 1990s, technological developments in molecular biology presented mouse behavioural geneticists with two new genetic strategies. The first strategy was to use targeted mutations to identify genes involved in [...]

Published
2008

5. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

Author

Aitman, Timothy J., Dong, Rong, Vyse, Timothy J., Norsworthy, Penny J., Johnson, Michelle D., Smith, Jennifer, Mangion, Jonathan, Roberton-Lowe, Cheri, Marshall, Amy J., Petretto, Enrico, Hodges, Matthew D., Bhangal, Gurjeet, Patel, Sheetal G., Sheehan-Rooney, Kelly, Duda, Mark, Cook, Paul R., Evans, David J., Domin, Jan, Flint, Jonathan, Boyle, Joseph J., Pusey, Charles D., and Cook, H. Terence

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Timothy J. Aitman (corresponding author) [1]; Rong Dong [1, 6]; Timothy J. Vyse [2, 6]; Penny J. Norsworthy [1, 6]; Michelle D. Johnson [1]; Jennifer Smith [3]; Jonathan Mangion [...]

Published
2006
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6. Mouse genomic variation and its effect on phenotypes and gene regulation

Author

Keane, Thomas M., Goodstadt, Leo, Danecek, Petr, White, Michael A., Wong, Kim, Yalcin, Binnaz, Heger, Andreas, Agam, Avigail, Slater, Guy, Goodson, Martin, Furlotte, Nicholas A., Eskin, Eleazar, Nellåker, Christoffer, Whitley, Helen, Cleak, James, Janowitz, Deborah, Hernandez-Pliego, Polinka, Edwards, Andrew, Belgard, Grant T., Oliver, Peter L., McIntyre, Rebecca E., Bhomra, Amarjit, Nicod, Jérôme, Gan, Xiangchao, Yuan, Wei, van der Weyden, Louise, Steward, Charles A., Bala, Sendu, Stalker, Jim, Mott, Richard, Durbin, Richard, Jackson, Ian J., Czechanski, Anne, Guerra-Assunção, José Afonso, Donahue, Leah Rae, Reinholdt, Laura G., Payseur, Bret A., Ponting, Chris P., Birney, Ewan, Flint, Jonathan, and Adams, David J.

Published
2011
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