6 results on '"Esteban, Miguel A."'
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2. Multimodal cell atlas of the ageing human skeletal muscle
- Author
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Lai, Yiwei, Ramírez-Pardo, Ignacio, Isern, Joan, An, Juan, Perdiguero, Eusebio, Serrano, Antonio L., Li, Jinxiu, García-Domínguez, Esther, Segalés, Jessica, Guo, Pengcheng, Lukesova, Vera, Andrés, Eva, Zuo, Jing, Yuan, Yue, Liu, Chuanyu, Viña, José, Doménech-Fernández, Julio, Gómez-Cabrera, Mari Carmen, Song, Yancheng, Liu, Longqi, Xu, Xun, Muñoz-Cánoves, Pura, and Esteban, Miguel A.
- Abstract
Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people1. Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing2. Yet, progress has been slow, partly due to the difficulties of characterizing skeletal muscle niche heterogeneity (whereby myofibres are the most abundant) and obtaining well-characterized human samples3,4. Here we generate a single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels. We describe how cell populations change during ageing, including the emergence of new populations in older people, and the cell-specific and multicellular network features (at the transcriptomic and epigenetic levels) associated with these changes. On the basis of cross-comparison with genetic data, we also identify key elements of chromatin architecture that mark susceptibility to sarcopenia. Our study provides a basis for identifying targets in the skeletal muscle that are amenable to medical, pharmacological and lifestyle interventions in late life.
- Published
- 2024
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3. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
- Author
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Moiseeva, Victoria, primary, Cisneros, Andrés, additional, Sica, Valentina, additional, Deryagin, Oleg, additional, Lai, Yiwei, additional, Jung, Sascha, additional, Andrés, Eva, additional, An, Juan, additional, Segalés, Jessica, additional, Ortet, Laura, additional, Lukesova, Vera, additional, Volpe, Giacomo, additional, Benguria, Alberto, additional, Dopazo, Ana, additional, Aznar-Benitah, Salvador, additional, Urano, Yasuteru, additional, del Sol, Antonio, additional, Esteban, Miguel A., additional, Ohkawa, Yasuyuki, additional, Serrano, Antonio L., additional, Perdiguero, Eusebio, additional, and Muñoz-Cánoves, Pura, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Cell transcriptomic atlas of the non-human primate Macaca fascicularis
- Author
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Han, Lei, primary, Wei, Xiaoyu, additional, Liu, Chuanyu, additional, Volpe, Giacomo, additional, Zhuang, Zhenkun, additional, Zou, Xuanxuan, additional, Wang, Zhifeng, additional, Pan, Taotao, additional, Yuan, Yue, additional, Zhang, Xiao, additional, Fan, Peng, additional, Guo, Pengcheng, additional, Lai, Yiwei, additional, Lei, Ying, additional, Liu, Xingyuan, additional, Yu, Feng, additional, Shangguan, Shuncheng, additional, Lai, Guangyao, additional, Deng, Qiuting, additional, Liu, Ya, additional, Wu, Liang, additional, Shi, Quan, additional, Yu, Hao, additional, Huang, Yunting, additional, Cheng, Mengnan, additional, Xu, Jiangshan, additional, Liu, Yang, additional, Wang, Mingyue, additional, Wang, Chunqing, additional, Zhang, Yuanhang, additional, Xie, Duo, additional, Yang, Yunzhi, additional, Yu, Yeya, additional, Zheng, Huiwen, additional, Wei, Yanrong, additional, Huang, Fubaoqian, additional, Lei, Junjie, additional, Huang, Waidong, additional, Zhu, Zhiyong, additional, Lu, Haorong, additional, Wang, Bo, additional, Wei, Xiaofeng, additional, Chen, Fengzhen, additional, Yang, Tao, additional, Du, Wensi, additional, Chen, Jing, additional, Xu, Shibo, additional, An, Juan, additional, Ward, Carl, additional, Wang, Zongren, additional, Pei, Zhong, additional, Wong, Chi-Wai, additional, Liu, Xiaolei, additional, Zhang, Huafeng, additional, Liu, Mingyuan, additional, Qin, Baoming, additional, Schambach, Axel, additional, Isern, Joan, additional, Feng, Liqiang, additional, Liu, Yan, additional, Guo, Xiangyu, additional, Liu, Zhen, additional, Sun, Qiang, additional, Maxwell, Patrick H., additional, Barker, Nick, additional, Muñoz-Cánoves, Pura, additional, Gu, Ying, additional, Mulder, Jan, additional, Uhlen, Mathias, additional, Tan, Tao, additional, Liu, Shiping, additional, Yang, Huanming, additional, Wang, Jian, additional, Hou, Yong, additional, Xu, Xun, additional, Esteban, Miguel A., additional, and Liu, Longqi, additional
- Published
- 2022
- Full Text
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5. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
- Author
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Mazid, Md. Abdul, primary, Ward, Carl, additional, Luo, Zhiwei, additional, Liu, Chuanyu, additional, Li, Yunpan, additional, Lai, Yiwei, additional, Wu, Liang, additional, Li, Jinxiu, additional, Jia, Wenqi, additional, Jiang, Yu, additional, Liu, Hao, additional, Fu, Lixin, additional, Yang, Yueli, additional, Ibañez, David P., additional, Lai, Junjian, additional, Wei, Xiaoyu, additional, An, Juan, additional, Guo, Pengcheng, additional, Yuan, Yue, additional, Deng, Qiuting, additional, Wang, Yang, additional, Liu, Ying, additional, Gao, Fei, additional, Wang, Junwen, additional, Zaman, Shahriar, additional, Qin, Baoming, additional, Wu, Guangming, additional, Maxwell, Patrick H., additional, Xu, Xun, additional, Liu, Longqi, additional, Li, Wenjuan, additional, and Esteban, Miguel A., additional
- Published
- 2022
- Full Text
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6. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration.
- Author
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Moiseeva, Victoria, Cisneros, Andrés, Sica, Valentina, Deryagin, Oleg, Lai, Yiwei, Jung, Sascha, Andrés, Eva, An, Juan, Segalés, Jessica, Ortet, Laura, Lukesova, Vera, Volpe, Giacomo, Benguria, Alberto, Dopazo, Ana, Aznar-Benitah, Salvador, Urano, Yasuteru, del Sol, Antonio, Esteban, Miguel A., Ohkawa, Yasuyuki, and Serrano, Antonio L.
- Abstract
Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration at all stages of life. The technical limitation of senescent-cell scarcity3 was overcome by combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol. We identified and isolated different senescent cell types from damaged muscles of young and old mice. Deeper transcriptome, chromatin and pathway analyses revealed conservation of cell identity traits as well as two universal senescence hallmarks (inflammation and fibrosis) across cell type, regeneration time and ageing. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing (inflammageing4) and arrests stem cell proliferation and regeneration. Reducing the burden of senescent cells, or reducing their inflammatory secretome through CD36 neutralization, accelerates regeneration in young and old mice. By contrast, transplantation of senescent cells delays regeneration. Our results provide a technique for isolating in vivo senescent cells, define a senescence blueprint for muscle, and uncover unproductive functional interactions between senescent cells and stem cells in regenerative niches that can be overcome. As senescent cells also accumulate in human muscles, our findings open potential paths for improving muscle repair throughout life.A lifetime cartography of in vivo senescent cells shows that they are heterogeneous. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing and arrests stem cell proliferation and tissue regeneration. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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