1. Inverse agonists exposed
- Author
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Black, J.W. and Shankley, N.P.
- Subjects
G proteins -- Models ,Genetically modified mice -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Analysis of a transgenic mouse model with an overexpressed excitatory cardiac receptor provides evidence for the existence of inverse agonists. This analysis also validates the two-state model of G-protein-coupled receptor activation. This validation equips the model with pharmacological applications in the characterization and development of drugs.
- Published
- 1995