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Abstract: Four new sesquiterpenoids, artemyrianins A–D (1–4), and three new norlignans, artemyrianins E–G (5–7), together with five known compounds (8–12), were isolated from the aerial parts of Artemisia myriantha(Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC50values ranging from 33.3 to 145.2 μM. Graphic Abstract:

Abstract: Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9and 10–12belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with IC50values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12and 17exhibited the stronger cytotoxicity than silybin (IC50, 169.6 μM) with IC50values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with IC50values of 10.7, 24.5 and 13.3 μM. Graphic Abstract: