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Coronarin E is a main diterpene ever isolated from Hedychium yunnanense. With the aim to enlarge its potential application, four butenolide derivatives (compounds 4a, 4b, 5a and 5b) were obtained from coronarin E via synthetic method, and their antibacterial effects were also evaluated. It is noteworthy that compounds 5a and 5b exhibited stronger antibacterial activities against most of the tested bacterial strains than ampicillin and kanamycin, two first- and second-line antimicrobials in clinical. For example, minimum inhibitory concentration (MIC) of 5a, 5b, ampicillin and kanamycin against Acinetobacter baumanii were 2, 1, 8 and 4 μg/mL, respectively, and MIC of the four compounds mentioned above against Klebsiella pneumonia were 1, 0.5, 16 and 4 μg/mL, respectively. The current studies not only enrich the structural diversity of diterpenes derived from Hedychium genus, but also provide potent candidates for the development of antibacterial medicines. [ABSTRACT FROM AUTHOR]

( − )-Arctigenin, an important active constituent of the traditional Chinese herb Fructus Arctii, was found to exhibit various bioactivities, so it can be used as a good lead compound for further structure modification in order to find a safer and more potent medicine. ( − )-Arctigenin derivatives1–5of ( − )-arctingen were obtained by modifying with ammonolysis at the lactone ring and sulphonylation at C (6′) and C (6″) andO-demethylation at CH3O-C (3′), CH3O-C (3″) and CH3O-C (4″), and their anticancer bioactivities were examined. [ABSTRACT FROM PUBLISHER]

The natural dibenzylbutyrolactone type lignanolide (–)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (–)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated. [ABSTRACT FROM PUBLISHER]